D M Brown – Research Publications and Patents 1948 -2008

  1. D M Brown & W C J Ross
    The condensation of p-Dimethylaminobenzaldehyde with 4-Methylpyrimidine derivatives. J. Chem. Soc., 1948, 1715-1716.
  2. D M Brown & G A R Kon.
    Some heterocyclic analogues of stilbenes. J. Chem. Soc., 1948, 2147-2154.
  3. D M Brown &B Lythgoe
    Deoxyribosides and related compounds. Part II. A proof of the furanose structure of the natural 2-deoxyribonucleosides. J. Chem. Soc., 1950, 1990-1991.
  4. D M Brown, L J Haynes & A R Todd
    Synthetic ribonucleoside-2′ phosphates; a correction. J. Chem. Soc., 1950, 408.
  5. D M Brown, L J Haynes & A R Todd
    Nucleotides Part VI. The structure of the synthetic nucleotides prepared from the benzylidene ribonucleosides. J. Chem. Soc., 1950, 2299-3304.
  6. D M Brown, L J Haynes & A R Todd
    Investigations on the problem of the ribonucleoside-2′ phosphates. J. Cell. Comp. Physiol., 1951, Suppl. 38, 15-19.
  7. D M Brown & A R Todd
    Nucleotides Part IX. The synthesis of adenylic acids a and b from 5′-trityladenosine. J. Chem. Soc., 1952, 44-51.
  8. D M Brown & A R Todd
    Nucleotides Part X. Some observations on the structure and chemical behaviour of the nucleic acids. J. Chem. Soc., 1952, 52-58.
  9. D M Brown, D I Magrath & A R Todd
    Nucleotides Part XII. The preparation of cyclic 2′, 3′-phosphates of adenosine, cytidine and uridine. J. Chem. Soc., 1952, 2708-2714.
  10. D M Brown, C A Dekker & A R Todd
    Nucleotides Part XIII. The action of ribonuclease on the 2′, 3′-phosphates or uridine and cytidine. J. Chem. Soc., 1952, 2715-2721.
  11. D M Brown, G C Fasman, D I Magrath, A R Todd, W Cochran and M M Woolfson.
    Structure of adenylic acids a and b. Nature, 1953, 172, 1184-1186.
  12. D M Brown, M Fried & A R Todd.
    The determination of nucleotide sequence in polyribonucleotides. Chem and Ind. 1953, 352-353.
  13. D M Brown and A.R. Todd
    Nucleotides. Part XXI. The action of ribonuclease on simple esters of the monoribonucleotides. J. Chem. Soc., 1953, 2040-2049.
  14. D M Brown & A R Todd
    Evidence on the nature of the chemical bonds in nucleic acids, in: “The Nucleic Acids”, 1954. Ed. Chargaff and Davidson. Academic Press Inc., Vol. I, Chapter 12, pp. 409-445.
  15. D M Brown
    The separation of nucleic acid degradation products in Ion exchange and its applications. Soc. Chem. Ind. 1955, 161-166.
  16. D M Brown, L A Heppel & R J Hilmoe
    Nucleotides. Part XXIV. The action of some nucleases on simple esters of monoribonucleotides. J. Chem. Soc., 1954, 40-46.
  17. D.M. Brown, D.I. Magrath and A.R. Todd
    Nucleotides. Part XXVI. The methylation of uridylic acid b. J. Chem. Soc., 1954, 14421447.
  18. D M Brown, G D Fasman, D I Magrath & A R Todd
    Nucleotides. Part XXVII. The structure of adenylic acids a and b. J. Chem. Soc., 1954, 1448-1455.
  19. D M Brown & A R Todd
    Nucleic acids. Annual rev. of Biochem., 1955, 24, 311-338.
  20. D M Brown, M Fried & A R Todd
    Nucleotides. Part XXXI. The stepwise degradation of polyribonucleotides: model experimens. J. Chem. Soc., 1955, 2206-2210.
  21. D M Brown and Mlle. F Baron
    Nucleotides. Part XXXIII. The structure of cytidylic acids a and b. J. Chem. Soc. 1955, 2855-2860.
  22. D M Brown, D I Magrath & A R Todd
    Nucleotides. Part XXXIV. The hydrolysis of dialkyl esters of uridine-3′ phosphate and its relevance to the question of phosphotriester linkages in ribonucleic acids. J. Chem. Soc., 1955, 4396-4410.
  23. D M Brown, D I Magrath, A H Neilson & A R Todd
    Hydrolysis of esters of monoribonucleotides. Nature, 1956, 177, 1124-1125.
  24. D M Brown, A R Todd & S Varadarajan.
    The structures of some acylcytosines. J. Chem. Soc., 1956, 2384-2387.
  25. D M Brown, A R Todd & S Varadarajan
    Nucleotides. Part XXXVII. The structure of uridylic acids a and b and a synthesis of spongouridine (3-b-D-Arabofuranosyluracil). J. Chem. Soc., 1956, 2388-2393.
  26. D M Brown, W Cochran, E H Medlin & S Varadarajan
    Nucleotides. Part XXXIX. 5′-Deoxy-5′-iodo-02:2′-cyclouridine: an X-ray crystallographic study. J. Chem. Soc., 1956, 4873-4877.
  27. D M Brown, A R Todd & S Varadarajan
    Nucleotides. Part XL. 02: 5′-cyclouridine and a synthesis of isocytidine. J. Chem. Soc., 1957, 868-872.
  28. D M Brown, A R Todd & S. Varadarajan
    Cyclonucleosides. Ciba Foundation Symposium on the chemistry and biology of purines. 1957, 108-116.
  29. D M Brown & Miss H M Higson
    Phospholipids. Part I. The hydrolysis of some esters of cyclohexanediol phosphates. J. Chem. Soc., 1957, 2034-2041.
  30. D M Brown & G O Osborne
    Phospholipids. Part II. The stability of some derivatives of 2-arninoethyl phosphate. J. Chem. Soc., 1957, 2590-2593.
  31. D M Brown, Mme. F Hayes & A R Todd
    Der abbau von glucose-3-phosphat durch alkali. Chem. Ber., 1957, 90, 936-941.
  32. D M Brown, D B Parihar, C B Reese & A R Todd
    The synthesis of 2′-deoxyuridine. Proc. Chem. Soc., 1957, 321.
  33. D M Brown, G E Hall & Miss H M Higson
    Phospholipids. Part III. The hydrolysis of the cis- and the trans-isomer of glycerol 1-(2-hydroxycyclohexyl phosphate) and related compounds. J. Chem. Soc., 1958, 1360-1366.
  34. D M Brown, D B Parihar, A R Todd & S Varadarajan
    Deoxynucleosides and related compounds. Part VI. The synthesis of 2-thiouridine and of 3′-deoxyuridine. J. Chem. Soc., 1958, 3028.-3035
  35. D M Brown, D B Parihar, C B Reese & A R Todd
    Deoxynucleosides and related compounds. Part VII. The synthesis of 2′-deoxyuridine and of thymidine. J. Chem. Soc., 1958, 3035-3038.
  36. D M Brown, D B Parihar & A R Todd
    Deoxynucleosides and related compounds. Part VIII. Some further transformations of O2:2′-cyclouridine. J. Chem. Soc., 1958, 4242-4244.
  37. D M Brown & G E Hall
    Phospholipids. Part IV. Myoinositol 2-phosphate. J. Chem. Soc., 1959, 357-359.
  38. D M Brown
    The Nucleic Acids and Heredity – British Scientists’ Theories on Evolution. The Amer. BioI. Teacher, 1959, 21, 7-9.
  39. D M Brown
    The nucleic acids. Ann. Rep. Chem. Soc., 1959, 330-342.
  40. D M Brown, G E Hall & R Letters
    Phospholipids. Part V. The hydrolysis of glycerol 1-esters of myoinositol 1- and 2-phosphate. J. Chem. Soc., 1959, 3547-3552.
  41. D M Brown & N K Hamer
    The solvolysis of dibenzyl trans-2-hydroxycyclohexyl phosphate. J. Chem. Soc., 1960, 406-410.
  42. D M Brown & N K Hamer
    Studies on phosphorylation. Part XIX. The P1’P1-diethylpyrophosphate ion. J. Chem. Soc., 1960, 1155-1161.
  43. D M Brown and P R Hammond
    Studies on phosphorylation. Part XX. The oxidation of mono- and di-alkyl phosphites. J. Chem. Soc., 1960, 4229-4232.
  44. D M Brown & P R Hammond
    Phospholipids. Part VI. Synthesis of phosphatidic acids and cephalins. J. Chem. Soc., 1960, 4232-4235.
  45. D M Brown & N K Hamer
    The use of phosphorohydrazidates as phosphorylating agents. Proc. Chem. Soc., 1960, 212.
  46. D M Brown, B F C Clark, G E Hall & R Letters
    The structure of a monophosphoinositide. Proc. Chem. Soc., 1960, 212.
  47. D M Brown & P Schell
    The reaction of hydroxylamine with cytosine and related compounds. J. Mol. Biol., 1961, 3, 709-710.
  48. D M Brown, B F C Clark & R Letters
    Phospholipids. Part VII. The structure of a monophosphoinositide. J. Chem. Soc., 1961, 3774-3779.
  49. D.M. Brown and B.F.C. Clark
    Structure of a monophosphoionositide from brain. Nature, 1962, 194, 1081-1083.
  50. D.M. Brown and B.F.C. Clark
    Phospholipids. Part VIII. Synthesis of (+)-trans-2-hydroxycyclohexyl phosphate and a calculation of the configuration of the myoinositol 1-phosphate residue in monophosphoinositide. J. Chem. Soc., 1963, 1475-1477.
  51. D M Brown & D A Usher
    Hydrolysis of phosphate diesters. Effect of a neighbouring hydroxyl group. Proc. Chem. Soc., 1963, 309-310.
  52. D.M. Brown
    Phosphorylation. In: Adv. in Org. Chem., Methods and Results, 1963, vol. 3. Ed. Raphael, Taylor and Winberg, Interscience, pp. 75-157.
  53. D M Brown, J A Flint & N K Hamer
    Studies in Phosphorylation. Part XXIV. The use of phosphorohydrazidates as phosphorylating agents. J.Chem. Soc., 1964, 326-335.
  54. D M Brown
    Chemistry of the nucleic acids, In: Comprehensive Biochemistry, 1963. Ed. Florkin and Stotz. Vol. 8, Part 2. Chapter III, pp. 209-269, Elsevier,
  55. D.M. Brown and J.C. Stewart
    Phospholipids. Part IX. phosphate elimination from glycolaldehyde phosphate. J. Chem. Soc., 1964, 5362-5364.
  56. D.M. Brown, M.G. Burdon and R.P. Slatcher
    Synthesis of 5-ribosyluracil and 5-ribosyluridine. Chemical Communications, 1965, 77.
  57. D M Brown & P Schell
    Nucleotides. Part XLVIII. The reaction of hydroxylamine with cytosine and related compounds. J. Chem. Soc., 1965, 208-215.
  58. D M Brown and J H Phillips
    Mechanism of the mutagenic action of hydroxylamine. J. Mol. Biol., 1965, 11, 663-671.
  59. J H Phillips, D M Brown, R Adman & L Grossman
    The effect of hydroxylamine on polynucleotide templates for RNA synthesis. J. Mol. Biol., 1965, 12, 818-828.
  60. D M Brown & A P Read
    Nucleotides. Part XLIX. The Reduction of the adduct of periodate-oxidised adenosine-5’phosphate and methylamine. J. Chem. Soc., 1965, 5072-5074.
  61. D M Brown & D A Usher
    Hydrolysis of hydroxyalkyl phosphate esters: effect of changing ester group. J. Chem. Soc., 1965, 6558-6564.
  62. D M Brown & D A Usher
    Hydrolysis of hydroxyalkyl phosphate esters: The epoxide route. J. Chem. Soc., 1965, 6547-6558.
  63. D M Brown & G H Jones
    Novel synthesis of halo- and deoxy-sugars. Chemical Communications, 1965, 561-562.
  64. D M Brown & J C Stewart
    The structure of triphosphoinositide from beef brain. Biochim. et Biophys. Acta, 1966, 125, 413-421.
  65. D M Brown, A D McNaught & P Schell
    The chemical basis of hydrazine mutagenesis. Biochem. Biophys. Res. Comm., 1966, 24, 967-971.
  66. D M Brown, J H Phillips & L Grossman
    Efficiency of induction of mutations by hydroxylamine. J. Mol. Biol., 1966, 21, 405-419.
  67. D M Brown & G H Jones
    Synthesis of some 3-deoxy-D-ribofuranose derivatives. J. Chem. Soc. (C), 1967, 249-252.
  68. D M Brown & G H Jones
    New syntheses of halogeno- and deoxy-sugars. J. Chem. Soc. (C), 1967, 252-256.
  69. D M Brown & M.J.A. Tanner
    The enzymatic synthesis and coding properties of oligonucleotides containing a 2′, 5′-internucleotide linkage at the 5′-end. Biochem. Biophys. Res. Comm., 1967, 26, 423-428.
  70. J H Phillips & D M Brown
    The mutagenic action of hydroxylamine. Prog. Nucleic Acid. Res., 1967, 7, 349-368.
  71. D M Brown
    The reaction of hydrazine with pyrimidine bases. Methods in Enzymology, 1967, 12, Part A, 31-34.
  72. D M Brown, M G Burdon & R P Slatcher
    The synthesis bf pseudouridine and of 5-D-ribofuranosyluridine. J. Chem. Soc. (C), 1968, 10511053.
  73. D M Brown & M G Burdon
    5-β-D-ribofuranosyluracil (pseudouridine). Synthetic Procedures in Nucleic Acid Chemistry, Vol. 1. Ed. W. Zorbach and R. Tipson, Interscience, 1968, pp 399-402.
  74. D M Brown & M J Frearson
    Hydrolysis of a-keto-phosphate triesters. Chemical Communications, 1968, 1342-1343.
  75. D M Brown & M J E Hewlins
    The reaction between hydroxylamine and cytosine derivatives. J. Chem. Soc., 1968, 1922-1924.
  76. D M Brown, M J E Hewlins & P Schell
    The tautomeric state of N(4)-hydroxy- and of N(4)-amino-cytosine derivatives. J. Chern. Soc. (C), 1968, 1925-1929.
  77. D M Brown & M J E Hewlins
    Dihydrocytosine and related compounds. J. Chem. Soc., 1968, 2050-2055.
  78. D M Brown, B F C Clark & M J A Tanner
    Studies on codons for tyrosyl transfer ribonucleic acid of yeast. European J. Biochem., 1968, 5, 492-499.
  79. M J Frearson & D M Brown
    Skeletal rearrangement of α-hydroxy-ketones upon electron impact. J. Chem. Soc., 1968, 2909-2912.
  80. D M Brown & M J E Hewlins
    Hydrogen-bond association of N(4)-hydroxycytosine with purines. Nature, 1969, 221, 656-657.
  81. D M Brown
    The chemical basis of biological mutation. Pure and Applied Chemistry, 1969, 18, 187-195.
  82. L Grossman & D M Brown
    The nature and influence of ultraviolet and hydroxylamine lesions in nucleic acids and the enzymic repair of the former. Ciba Foundation Symp. “Mutation as Cellular Process”. Ed. G.E.W. Wolstenholme and M. O’Connor, Churchill, London, 1969, 109-131.
  83. 83. D M Brown
    Aspects of phosphate ester chemistry as applied to the phosphoinositides. Ann. New York Acad. Sci., 1969, 165, 687-694.
  84. D M Brown & P F Coe
    Stereochemistry of the addition reaction of hydroxylamine and methoxyamine with 1-methyl-cytosine. Chemical Communications, 1970, 568-569.
  85. D.M. Brown & P F Coe
    Electrophilic substitution at C-5 in 1-methyl-5,6-dihydrocytosine. Chemical Communications, 1970, 864-865.
  86. A Giner-Sorolla & D.M. Brown
    Synthesis of 6,8-disubstituted purines. J. Chem. Soc. (C), 1971, 126-128.
  87. D M Brown & A Giner-Sorolla
    Vilsmeier reaction of 6-methylpurine. J. Chem. Soc. (C). 1971, 128-132.
  88. A R Cashmore, D M Brown & J D Smith
    Selective reaction of methoxyamine with cytosine bases in tyrosine transfer ribonucleic acid. J. Mol. Biol., 1971, 59, 359-373.
  89. G R Banks, D M Brown, D G Streeter & L Grossman
    Mutagenic analogues of cytosine: RNA polymerase template and substrate studies. J. Mol. BioI., 1971, 60, 425-439.
  90. D M Brown & M R Osborne
    The reactions of adenosine with hydroxylamine. Biochim. Biophys. Acta., 1971, 247, 514-518.
  91. D M Brown, P F Coe & D P L Green
    The synthesis and some properties of 1-(2-amino-oxyethyl)cytosines. J. Chem. Soc. (C), 1971, 867-869.
  92. D M Brown & M Taylor
    The synthesis of some I-substituted cytosine and uracil derivatives. J. Chem. Soc. (Perkin I), 1972, 2385-2391.
  93. S E Chang, A R Cashmore & D M Brown
    Selective modification of uridine and guanosine residues in tyrosine transfer ribonucleic acid. J. Mol. BioI., 1972, 68, 455-464.
  94. B C F Chu, D M Brown & M G Burdon
    Effect of nitrogen and of catalase on hydroxylamine and hydrazine mutagenesis. Mutation Research, 1973, 20, 265-270.
  95. B C F Chu, D M Brown & M G Burdon
    N(4)-amino- and N(4)-hydroxycytosines as base analogue mutagens. Mutation Research, 1974, 23, 267-273.
  96. D M Brown
    Chemical reactions of polynucleotides and nucleic acids. Basic Principles in Nucleic Acid Chemistry. Ed. T’’so. Academic Press, New York, Vol. II, Chapter 1, pp. 1-90.
  97. I L Batey & D M Brown
    The selective iodination of yeast phenylalanine transfer RNA with 125I. Mol. BioI. Reports. 1975, 2, 65-71.
  98. G M Blackburn, V C Solan, D M Brown & P F Coe
    Deuteriodeprotonation of methylcytosines by hydroxylamine in D20 solution. J. Chem. Soc. Chem. Comm., 1976, 724-726.
  99. I L Batey & D M Brown
    Chemical studies of the tertiary structure of transfer RNA. Iodination of exposed cytosine residues with 1251. Biochim. Biophys. Acta, 1977, 474, 378-385.
  100. D Bridges, D M Brown & R C Ogden
    2′-Deoxypseudouridine. J. Chem Soc. Chem. Comm., 1977, 460-461.
  101. M Brown, G H Jones, B E Looker, C D McLean & S Middleton
    Oxidation of alkylhydrazines by iodine. J. Chem. Soc. Perkin I, 1977, 2052-2056.
  102. D M Brown, S.D. Bridges, R.C. Ogden and R.P.L. Conrad
    The synthesis of the isomeric 2′-deoxypseudouridines. Nucleic Acids Res., Special publication No.4, 1978, 121-123.
  103. G M Blackburn, D M Brown & V C Solan
    Kinetic studies of deuterium exchange at C-5 of uracil and cytosine derivatives. Nucleic Acids Res., Special publication No.4, 1978, 121-123.
  104. T Friedman & D M Brown
    Base-specific reactions useful for DNA sequencing: methylene blue – sensitised photooxidation of guanine and osmium tetraoxide modification of thymine. Nucleic Acids Res., 1978, 5, 615-622.
  105. S Salisbury & D M Brown
    Electrophilic substitution in dihydrouracils. J. Chem. Soc. Chem. Comm., 1979, 656-657.
  106. A M Mubarak & D M Brown
    A simple, stereospecific synthesis of (+)-muscarine. Tetrahedron Letters, 1980, 2, 2453-2454.
  107. A.M. Mubarak & D M Brown
    A synthesis of β-2’-deoxyshowdomycin. Tetrahedron Letters, 1981, 22, 683-684.
  108. D M Brown & R C Ogden
    A synthesis of pseudouridine. J. Chem. Soc. Perkin 1, 1981, 723-725.
  109. A M Mubarak &D M Brown
    A stereospecific synthesis of (+)-muscarine. J. Chem. Soc. Perkin I, 1982, 809-813.
  110. A M Mubarak and D M Brown
    The conformation of (+)-muscarine in solution. Tetrahedron, 1982, 38, 41.
  111. D M Brown, J Frampton, P Goelet & J Karn
    Sensitive detection of RNA using strand-specific M13 probes. Gene, 1982, 20, 139-144.
  112. N Gautham, P Ramakrishnan, T P Seshadri, M A Viswamitra, S A Salisbury & D M Brown
    Structure of a thionucleoside: 5′-deoxy-5′,6-epithio-5, 6-dihydro-2′,3′-0-isopropylidene-3-methyluridine. Acta Cryst., 1982 B38, 2707-2709.
  113. N Gautham, T P Seshadri, M A Viswamitra, S A Salisbury and D M Brown
    Structure of 5′-deoxy-5′,6-epithio-5,6-dihydro-2′,3′-O-isopropylidineuridine. Acta Cryst., 1983, C39, 1389-1392.
  114. B S Sproat and D M Brown
    A new linkage for solid phase synthesis of oligodeoxynucleotides. Nucleic Acids Res., 1985, 13, 2979-2987.
  115. J Dibb, D M Brown, J Karn, D G Moerman, S L Bolten & R H Waterson
    Sequence analysis of mutations that affect the synthesis, assembly and enzymatic activity of the unc-54 myosin heavy chain of Caenorhabditis elegans. J. Mol. BioI. 1985, 183, 543-551.
  116. E J Mitchell, R Jakes, J Karn, A Newman, D M Brown and J Kendrick-Jones
    Mapping the actin light chain binding sites of myosin S1. J. Muscle Res. and Cell Motility, 1986, 7, 369.
  117. D M Brown, N N Anand & S A Salisbury
    Base analogue interactions in DNA duplexes. Nucleosides and Nucleotides, 1987, 6, 317-320.
  118. N N Anand, D M Brown & S A Salisbury
    Stability of oligonucleotide duplexes containing degenerate bases. Nucleic Acids Res., 1987, 15, 8167-8176.
  119. P V S Kong Thoo Lin & D M Brown
    Base analogues related to N4-hydroxycytosine. Nucleosides and Nucleotides, 1989, 8, 871-874
  120. E J Mitchell, J Karn, D M Brown, A Newman, R Jakes & J Kendrick-Jones
    Regulatory and essential light-chain-binding sites in myosin heavy chain subfragment-l mapped by site-directed mutagenesis. J. Mol. Biol., 1989, 208, 199 – 205.
  121. P Kong Thoo Lin & D M Brown
    Synthesis of derivatives of 3,4-dihydro-6H,8H-pyrimido[4,5-c][1,2]oxazin-7-one. Heterocycles, 1989, 29, 1735 – 1740.
  122. P Kong Thoo Lin & D M Brown
    Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. Nucleic Acids Res., 1989, 17, 10373-10383.
  123. A Rosenthal, B S Sproat & D M Brown
    A new guanine-specific reaction for chemical DNA sequencing using m-perbenzoic acid. Biochem. Biophys. Res. Commun., 1990, 173 ,272 – 275.
  124. D M Brown & P K Thoo Lin
    The application of oligodeoxyribonucleotides containing degenerate bases. Coll. Czech. Chem. Commun., (Special Issue No. 1), 1990, S5, 213 – 215.
  125. L Van Meervelt, M H Moore, P Kong Thoo Lin, D M Brown & O Kennard
    Molecular and Crystal Structure of d(CMO4CGmo4CG): N4-methoxycytosine. guanine base pairs in Z-DNA. J. Mol. Biol., 1990, 216, 773-781.
  126. L Van Meervelt, M H Moore, P Kong Thoo Lin, D M Brown & O Kennard
    Molecular and Crystal Structure of d(CGCGmo4CG):N4-Methoxycytosine Guanine base pairs in Z-DNA. Nucleosides and Nucleotides, 1990, 9, 467-469.
  127. S Agrawal, J Y Tang & D M Brown
    Analytical study of phosphorothioate analogues of oligodeoxynucleotides using high-performance liquid chromatography. J. Chromatog., 1990, 509, 396-399.
  128. D M Brown & P K Thoo Lin.
    Synthesis and Stability of Oligonucleotides containing adenine-guanine analogues. Carbohydrate Res., 1991, 216, 129-139.
  129. P Kong Thoo Lin & D M Brown
    Synthesis and Duplex stability of oligonucleotides containing purine base analogues. Nucleosides and Nucleotides, 1991, 10, 675-677.
  130. D M Brown & P Kong Thoo Lin
    The Structure and Application of Oligodeoxynucleotides containing Modified, Degenerate Bases. 1991, Nucleic Acids Res. Symp. Series, No. 24, 209-212.
  131. A N R Nedderman, M J Stone, P Kong Thoo Lin, D M Brown & D H Williams
    Base Pairing of Cytosine Analogues with Adenine and Guanosine in Oligonucleotide Duplexes: Evidence for Exchange between Watson-Crick and Wobble Base Pairs using IH NMR Spectroscopy. Chem. Comm., 1991, 1357-1359.
  132. M J Stone, A N J Nedderman, D H Williams, P Kong Thoo Lin & D M Brown
    The Molecular Basis of Methoxyamine Initiated Mutagenesis: 1H NMR Studies of Base-Modified Oligonucleotides. J. Mol. Biol., 1991, 222, 711-723.
  133. P Kong Thoo Lin & D M Brown
    Synthesis of oligodeoxynucleotides-containing degenerate bases as primers in the polymerase chain reaction. Nucl. Acids. Res., 1992, 20, 5149-5152.
  134. A N R Nedderman, M J Stone, D H Williams, P Kong Thoo Lin & D M Brown
    Molecular-basis for methoxyamine-initiated mutagenesis – 1H nuclear-magnetic-resonance studies of oligonucleotide duplexes containing base-modified cytosine residues. J. Mol. Biol. 1993, 230, 1068-1076.
  135. D M Brown
    A brief history of olignucleotide synthesis, In: Methods in Molecular Biology, 20: Protocols for oligonucleotides and analogues. (ed. S Agrawal), Human Press Inc., 1993, Chap. 1., 1-18.
  136. P Kong Thoo Lin & D M Brown
    Oligonucleotides containing degenerate bases. In: Methods in Molecular Biology, 26: Protocols for oligonucleotide conjugates. (ed. S Agrawal), Humana Press Inc., 1994, Chap. 7., 187-206.
  137. D M Brown, P Kong Thoo Lin & L Van Meervelt
    Structure of 4-nitrobenzyl N-(4-nitrobenzyloxy)trifluoroacetimidate Acta Cryst. (C). 1993, 49, 1209-1211.
  138. D Loakes & D M Brown
    Synthesis of antiviral compounds with ambivalent hydrogen bonding potential. Coll. Czech Chem. Commun. (Special Issue), 1993, 58, 29-32.
  139. D M Williams & D M Brown
    Conformationaly-restrained Degenerate Nucleoside Analogues. Presentation at Nucleosides and Nucleotides Round Table, Leuven, Belgium, Sept. 1994.
  140. D M Williams & D M Brown
    Conformationally restrained degenerate base analogues. Coll. Czech Commun. (Special Issue), 1993, 58, 41-43.
  141. D Loakes and D M Brown
    Synthesis of bicyclic N4-oxycytidine derivatives. Nucleosides & Nucleotides, 1994, 13, 679-688.
  142. P Kong Thoo Lin, N M Maguire & D M Brown
    Synthesis of novel oxa-isosteres of spermidine and spermine. Tetrahedron Letters, 1994, 35, 3605-3608.
  143. H Kamiya, N Murata-kamiya, P Kong Thoo Lin, D M Brown & E Ohtsuka
    Nucleotide incorporation opposite degenerate bases by Taq DNA-polymerase. Nucleosides & Nucleotides, 1994, 13, 1483-1492.
  144. D Loakes & D M Brown
    5-Nitroindole as an universal bas analogue. Nucleic Acids Res., 1994, 22, 4039-4043.
  145. D Loakes, D M Brown, N Mahmood, J Balzarini & E De Clercq
    Antiviral activity of N4-aminocytidine derivatives related to AZT. Antiviral Chem. & Chemotherapy, 1995, 6, 9-16.
  146. D Loakes & D M Brown
    The Synthesis of bicyclic N4-amino-2’-deoxycytidine derivatives. Nucleosides & Nucleotides, 1995, 14, 291-293.
  147. D M Williams & D M Brown
    Some pyrrolopyrimidine chemistry directed to the synthesis of tricyclic purine analogues. J. Chem. Soc. Perkin Trans. 1, 1995, 1225-1231.
  148. D Loakes, F Hill, S Linde & D M Brown
    Nitroindoles as universal bases. Nucleosides & Nucleotides, 1995, 14, 1001-1003.
  149. L Van Meervelt, M H Moore, P Kong Thoo Lin & D M Brown
    To wobble or not to wobble: modified bases incorporated into DNA. Nucleosides & Nucleotides, 1995, 14, 1057-1059.
  150. M H Moore, L Van Meervelt, S A Salisbury, P Kong Thoo Lin & D M Brown
    Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA Z-form duplex – significance for base analogue mutagenesis.
    J. Mol. Biol., 1995, 251, 665-673.
  151. D Loakes, D M Brown, S Linde & F Hill. 3-Nitropyrrole and 5-nitroindole as universal bases in primers for DNA-sequencing and PCR. Nucleic Acids Res., 1995, 23, 2361-2366.
  152. D Loakes, D M Brown, N Mahmood, J Balzarini & E DeClercq
    Antiviral activity of bicyclic pyrimidine nucleosides. Antiviral Chem. & Chemotherapy, 1995, 6, 371-378.
  153. K Negishi, D M Williams, Y Inoue, T Limuras, M Katahira, H Kanazawa, S Uesugi, H Hayatsu & D M Brown
    Mechanism of mutagenesis induced by cytosine analogues bearing N(4)-substitutions. Nucleic Acids Res., 1995, Symp. Series No. 34, 231-232
  154. L Van Meervelt, P Kong Thoo Lin & D M Brown
    6-(3,5-Di-O-acetyl-b-D-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimidol[4,5-c][1,2]-oxazin-7(6H)-one. Acta Cryst. (C), 1995, 51, 1347-1350.
  155. M Zaccolo, D M Williams, D M Brown & E Gherardi
    An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues. J. Mol. Biol., 1996, 255, 589-603.
  156. D Loakes, A Van Aerschot, D M Brown & F Hill
    Enzymatic recognition of acyclic universal base analogues in oligonucleotides. Nucleosides and Nucleotides, 1996, 15, 1891-1904.
  157. D M Williams, D Y Yakovlev & D M Brown
    The synthesis of a tricyclic pyrrolopyrimidine related to N6-hydroxyadenine. J. Chem. Soc. Perkin Trans. 1, 1997, 1171-1178.
  158. K Negishi, D M Williams, Y Inoue, K Moriyama, D M Brown & H Hayatsu
    The mechanism of mutation induction by a hydrogen bond ambivalent, bicyclic N4-oxy-2’-deoxycytidine in Escherichia coli. Nucleic Acids Res., 1997, 25, 1548-1552.
  159. D Loakes, F Hill, D M Brown & S A Salisbury
    Stability and structure of DNA oligonucleotides containing non-specific base analogues. J. Mol. Biol., 1997, 270, 426-435.
  160. D M Brown, M Zaccolo, D Loakes & F Hill
    Random mutagenesis of DNA using deoxynucleoside 5’-triphosphate analogues. Life Science News, 1997, 23, 32-34.
  161. F Hill, D Loakes & D M Brown
    Properties of oligonucleotides containing the transition bases P and K. Nucleosides & Nucleotides, 1997, 16, 1507-1511.
  162. 162. F Hill, D M Williams, D Loakes & D M Brown
    Comparative mutagenicities of N6-methoxy-2,6-diaminopurine- and N6-methoxyaminopurine 2’-deoxyribonucleosides. Nucleic Acids Res., 1998, 26, 1144-1149.
  163. C L Smith, A C Simmonds, I R Felix, A L Hamilton, S Kumar, S Nampalli, D Loakes, F Hill & D M Brown
    DNA polymerase incorporation of universal base triphosphates. Nucleosides & Nucleotides, 1998, 17, 541-554.
  164. C L Smith, A C Simmonds, A L Hamilton, D L Martin, A G Lashford, D Loakes, F Hill & D M Brown
    Use of 5-nitroindole 2’-deoxyribosyl 5’-triphosphate for labelling and detection of oligonucleotides. Nucleosides & Nucleotides, 1998, 17, 555-564.
  165. F Hill, D Loakes & D M Brown
    Polymerase recognition of synthetic oligodeoxyribonucleotides incorporating degenerate pyrimidine and purine bases. Proc. Nat. Acad. Sci., USA, 1998, 95, 4258-4263.
  166. K Moriyama, K Negishi, M S J Briggs, C L Smith, F Hill, M J Churcher, D M Brown & D Loakes
    Synthesis and RNA polymerase incorporation of the degenerate ribonucleotide analogue rPTP. Nucleic Acids Res., 1998, 26, 2105-2111.
  167. S Kukreti, J-S Sun, D Loakes, D M Brown, C-H Nguyen, E Bisagni, T Garestier & C Helene.
    Triple helices formed at oligopyrimidine•oligopurine sequences with base pair inversions: effect of a triplex-specific ligand on stability and selectivity. Nucleic Acids Res., 1998, 26, 2179-2183.
  168. D Loakes, D M Brown and S A Salisbury
    Cyclisation and rearrangement of N4-acylamidodeoxycytidines. Tetrahedron Letters, 1998, 39, 3865-3868.
  169. G Schuerman, L Van Meervelt, D Loakes, D M Brown, P Kong Thoo Lin & S A Salisbury
    A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex. J. Mol. Biol., 1998, 282, 1005-1011.
  170. D M Williams, D Loakes & D M Brown
    The synthesis of a hydrogen-bond degenerate tricyclic pyrrolopyrimidine nucleoside and of its 5’-triphosphate. J. Chem. Soc. Perkin 1, 1998, 3565-3570.
  171. S Ball, M A Reeve, P S Robinson, F Hill, D M Brown & D Loakes
    The use of tailed octamer primers for cycle sequencing. Nucleic Acids Res., 1998, 26, 5225-5227.
  172. D Loakes, D M Brown & S A Salisbury
    A Dimroth rearrangement of pyrimidine nucleosides. J. Chem. Soc., Perkin Trans. 1, 1999, 1333-1337.
  173. F Hill, I R Felix, M G McDougall, S Kumar, D Loakes & D M Brown
    Random mutagenesis using 2-Amino-9-(2-deoxy-β-D-ribofuranosyl) purine-5’-triphosphate and the polymerase chain reaction. Nucleosides & Nucleotides, 1999, 18, 2677-2684.
  174. F Hill, D Loakes, C L Smith, D M Williams & D M Brown
    Synthesis and polymerase incorporation properties of a tricyclic pyrrolopyrimidine related to N6-Hydroxy-2’-Deoxyadenosine.
    Nucleosides & Nucleotides, 1999, 18, 573-574.
  175. K Moriyama, D M Williams, D Loakes, D M Brown, H Hayatsu & K Negishi
    Properties of mutagenic pyrimidine analogue, P. Nucleic Acids Symp. Series, No. 39, 1998, 245-246.
  176. D Loakes, R Bazzanini & D M Brown
    The Synthesis of Bicyclic N4-Amino-2’-deoxycytidine derivatives. Hel. Chim. Acta, 1999, 82, 2028-2036.
  177. D Loakes, F Hill, D M Brown, S Ball, M A Reeve & P S Robinson
    5’-Tailed Octanucleotide Primers for Cycle Sequencing. Nucleosides & Nucleotides, 1999, 18, 2685-2695.
  178. D Loakes, M-J Guo, J-C Yang & D M Brown
    The Synthesis of Pyrimido-pyridazinone and Pyrrolidino-pyrimidinone 2’-Deoxynucleoside Derivatives. Helv. Chim. Acta, 2000, 83, 1693-1700.
  179. D Loakes, M-J Guo, D M Brown, S A Salisbury, C L Smith, I Felix, S Kumar & S Nampalli.
    Synthesis and incorporation of pyrrolecarboxamide nucleoside triphosphates by DNA polymerases.
    Nucleosides, Nucleotides & Nucleic Acids, 2000, 19, 1599-1614.
  180. D M Brown & Sir Hans Kornberg
    Alexander Robertus Todd. Biog. Mems Fell. R. Soc. Lond., 2000, 46, 515-532.
  181. D Loakes, R Bazzanini & D M Brown
    The synthesis of bicyclic N4-amino-2’deoxycytidine Derivatives. Perspectives in Nucleoside and Nucleic Acid Chemistry, M V Kisakurek and H Rosemeyer (Eds.) Wiley-VCH, Zurich, 2000, 1-9.
  182. D Loakes & D M Brown
    The synthesis and reactions of N4-amino-2’-deoxycytidine derivatives. Recent Research Developments in Organic and Bioorganic Chemistry, Transworld Research Network, 2001, 4, 89-95.
  183. D Loakes, M J Guo, J C Yang & D M Brown
    The syntheses of pyrimido-pyridazinone and pyrrolidino-pyrimidinone 2’-deoxynucleoside derivatives. Hominatio, M V Kisakurek (Ed), Wiley-VCH, Zurich, 2001, 1693-1700.
  184. D Loakes, D M Brown, S A Salisbury, M G McDougall, C Neagu, S Nampalli & S Kumar
    Synthesis and some biochemical properties of a novel 5,6,7,8-tetrahydropyrimido[4,5-c]pyridazine nucleoside. Helv Chim Acta, 2003, 86, 1193-1204.
  185. D Loakes, D M Brown, S A Salisbury, M G McDougal, C Neagu, S Nampalli & S Kumar
    Synthesis and enzymatic incorporation of a novel bicyclic pyrimidine nucleoside: a thymidine mimic. Tetrahedron Letters, 2003, 44, 3387-3389.
  186. J Baddiley & D M Brown
    Alexander Todd: a new direction in organic chemistry. In The 1702 Chair of Chemistry at Cambridge, Archer, M.D., Haley, C.D. Eds., Cambridge University Press, Cambridge, 2005, 210-236.
  187. K Too, D M Brown & D Loakes
    Mutagenic nucleoside analogues for use as antivirals by error catastrophe. Coll. Czech. Chem. Comm. Symp. Series, 2005, 7, 315-318.
  188. K Too, D Loakes, P Holliger & D M Brown
    Effect of a hydrogen bonding carboxamide group on universal bases. Coll. Czech. Chem. Commun., 2006, 71, 899-911.
  189. G W Kenner & D M Brown (Eds.) Phosphoric Esters and Related Compounds (Sp. Publ. No. 8) Symp. Chem. Soc. Anniv. Meeting, Cambridge, 1957, 1-183.
  190. Lord Todd & D M Brown. Ed. Engl. Trans. Of N K Kochetkov and E I Budovskii Organic Chemistry of Nucleic Acids, Parts A and B. Plenum Press, London, 1972.
  191. D M Brown, & M E Tate
    pH and cation dependent conformation of cyclitolphosphates. Proc. Aust. Biochem. Soc., 1973, 6, 44.
  192. D M Brown
    Nucleic acid chemistry: past, present and future. Nucl. Acids Symp. Series, No. 31, 1994, 1.
  193. K Too, D M Brown, E Bongard, L Vivas & D Loakes
    In Vitro antimalarial activity of N6-modified purine analogues. Nucleosides, Nucleotides & Nucleic Acids, 2007, 26.
  194. K Too, D M Brown, E Bongard, L Vivias, V Yardley & D Loakes
    Antimalarial activity of N6-modified purine analogues. Biorg. Med. Chem., 2007, 15, 5351-5362.
  195. J D Graci, D A Harki, V S Korneeva, J P Edathil, K Too, D Franco, E D Smidansky, A V Paul, B R Peterson, D M Brown, D Loakes & C E Cameron
    Lethal mutagenesis of polio virus caused by poliovirus polymerase-dependent and –independent incorporation of a mutagenic pyrimidine analog. J. Virol. 2007, 81, 11256-11266.
  196. J D Graci, K Too, E D Smidansky, J P Edathil, E W Barr, J E Galarraga, J M Bollinger, B R Peterson, D Loakes, D M Brown & C E Cameron
    Lethal mutagenesis of picornaviruses with N6-modified purine nucleoside analogues. Antimicrobial Agents and Chemotherapy, 2008, 52, 971-979.

Patents

  1. GB Application No. 9519425.4 filed on 22/09/1995 (WO 97/11083)
  2. GB Application No. 9602028.4 filed on 01/02/1996 (WO 97/28176)
  3. GB Application No. 97302265.0 filed on 02/04/1997 (WO 98/43991)
  4. GB Application No. 9716231.7 filed on 31/07/19097 (WO 99/06422)
  5. GB Application No. 0016258.6 filed on 03/07/2000 (WO 02/02584)
  6. GB Application No. 0126701.2 filed on 07/11/2001 (WO 03/039450)
  7. US Application No. 10/207,005 filed on 30/07/2002
  8. GB Application No. 0610317.0 filed on 24/05/2006