LMB Group Leaders - A to G
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M Madan Babu |
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| LMB Division: |
Structural Studies |
| Research: |
Systems biology |
| Summary: |
The molecules of life, such as proteins, nucleic acids and metabolites have traditionally been studied in isolation. Recently, it is becoming increasingly clearthat they are tied together to form a large, inter-linked, complex system, which is best represented and investigated as a network. More...
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Anne Bertolotti |
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| LMB Division: |
Neurobiology |
| Research: |
Cellular aspects of protein misfolding in neurodegenerative diseases |
| Summary: |
Deposition of proteins of aberrant conformation is the hallmark of several neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and prion disorders. Cells have elaborated quality control mechanisms to protect them from the deleterious effect of misfolded proteins. More... |
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Alexander G. Betz |
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| LMB Division: |
Protein and Nucleic Acid Chemistry |
| Research: |
The initiation of immune responses |
| Summary: |
The decision whether to launch an adaptive immune response or not is predominantly made through the interaction of three types of cells: antigen presenting cells (dendritic cells and possibly B cells); pro-inflammatory TH cells; and TR cells. We would like to understand the molecular processes that govern the interactions of cells during the initiation of immune responses. More... |
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Mariann Bienz |
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| LMB Division: |
Protein and Nucleic Acid Chemistry |
| Research: |
Molecular mechanisms of Wnt signal transduction |
| Summary: |
The Wnt signalling pathway controls animal development and tissue homeostasis, and is also a major cancer pathway. Its key
effector is Β-catenin, which is stabilized in response to Wnt stimulation; it thus binds to TCF factors in the nucleus, and functions as a co-activator to mediate Wnt-induced transcription. Inappropriate activation of β-catenin can cause cancer in many human tissues, most notably colorectal cancer. More... |
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Simon Bullock |
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| LMB Division: |
Cell Biology |
| Research: |
Mechanisms of cytoplasmic mRNA transport |
| Summary: |
Molecular motors have critical roles in trafficking of organelles and macromolecules within the cytoplasm, and aberrant motor function has been implicated in diseases such as neurodegeneration. More... |
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Andrew Carter
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| LMB Division: |
Structural Studies |
| Research: |
The Structure and Mechanism of Dynein
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| Summary: |
The contents of eukaryotic cells are organised and moved around by motor proteins running along the tracks that make up the cytoskeleton (microtubules and actin filaments). The largest and most complicated of these is the microtubule motor cytoplasmic dynein. More... |
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Jason Chin |
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| LMB Division: |
Protein and Nucleic Acid Chemistry |
| Research: |
Evolution and synthesis of new function |
| Summary: |
Biomolecules and their dynamic assemblies, in collaboration with the energy provided by NTP hydrolysis, perform a spectacular range of mechanical and chemical manipulations on nanometre scale objects in the cell; molecular motors perform mechanical work, while enzymes rearrange atoms in ways, and at rates that synthetic chemists have difficulty emulating. More... |
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Bazbek Davletov |
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| LMB Division: |
Neurobiology |
| Research: |
Molecular mechanisms of vesicle fusion |
| Summary: |
Progress in neurobiology requires a full description of the molecular mechanisms underlying neurotransmitter release and neuronal growth. We are defining, in mechanistic terms, the molecular cascades of protein and lipid interactions that lead to vesicle fusion. The knowledge of these molecular cascades will lead to increased understanding of brain function and of secretion of hormones throughout the body. More... |
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Mario de Bono |
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| LMB Division: |
Cell Biology |
| Research: |
Neural circuits and behaviour |
| Summary: |
Brains are highly parallel information processors. Their neural circuits continuously integrate sensory inputs to generate appropriate behavioural responses. More... |
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Phil Evans |
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| LMB Division: |
Structural Studies |
| Research: |
Structural studies of endocytosis components |
| Summary: |
Macromolecules are moved into cells and between cellular compartments by the movement of membrane vesicles containing protein and lipid cargo. The formation of these vesicles involves the assembly of complex protein machinery to invaginate the membrane, typically forming a polyhedral coat of clathrin around the vesicle. More... |
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Alan Fersht |
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| LMB Division: |
Protein and Nucleic Acid Chemistry |
| Research: |
Tumour suppressor p53 structure and drug discover |
| Summary: |
We use an amalgam of protein engineering, structural biology, biophysics and chemistry to study the structure, activity, stability and folding of proteins, and the role of protein misfolding and instability in cancer and disease. We focus on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53, in order to design novel anti-cancer drugs that function by restoring the activity of mutated proteins. More... |
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Matthew Freeman |
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| LMB Division: |
Cell Biology |
| Research: |
Morphogenesis and rhomboids |
| Summary: |
We study two overlapping but distinct topics: how epithelial and tissue architecture is controlled, and intramembrane proteolysis by rhomboids. More... |
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Michael Gait |
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| LMB Division: |
Protein and Nucleic Acid Chemistry |
| Research: |
Therapeutic oligonucleotides and their peptide conjugates |
| Summary: |
Our work focuses on the chemical synthesis of modified oligonucleotides, siRNA, peptide nucleic acids (PNA), and their peptide conjugates to target essential RNA structures inside cells for a variety of potential therapeutic applications. More... |
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Michel Goedert |
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| LMB Division: |
Neurobiology |
| Research: |
Molecular mechanisms of neurodegeneration |
| Summary: |
Alzheimer’s disease and Parkinson’s disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in several related disorders. The events leading to filament formation or the mere presence of filaments are believed to produce nerve cell degeneration. More... |
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Ingo Greger |
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| LMB Division: |
Neurobiology |
| Research: |
Glutamate-gated ion channels: biogenesis & trafficking |
| Summary: |
Glutamate-gated ion channels (iGluRs) mediate the majority of fast excitatory neurotransmission in vertebrate brains. These receptors are instrumental for the formation of neuronal circuits, and are key regulators of synaptic function and plasticity. iGluRs are heterotetramers, and comprise three functionally distinct subtypes: AMPA, NMDA and kainate receptors. More... |
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Group Leaders