A to G


M. Madan Babu
LMB Division - Structural Studies
Regulatory Genomics and Systems Biology

The molecules of life, such as proteins, nucleic acids and metabolites, have traditionally been studied in isolation. It is becoming increasingly clear that they are tied together to form a large, inter-linked, complex system that is highly regulated at multiple levels of organization. More…

David Barford
LMB Division - Structural Studies
Molecular mechanisms of the anaphase-promoting complex and the mitotic checkpoint

The anaphase-promoting complex (APC/C) is a large multi-subunit complex (~1.2 MDa) that functions to regulate cell cycle transitions, specifically the metaphase to anaphase transition in mitosis (when duplicated sister chromatid pairs are separated), the exit from mitosis and maintenance of G1. More…

Anne Bertolotti
LMB Division - Neurobiology
Understanding and preventing the deposition of misfolded proteins

Deposition of proteins of aberrant conformation is the hallmark of several neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and prion disorders. Cells have elaborate quality control mechanisms to protect them from the deleterious effect of misfolded proteins. More…

mariann-bienz
Mariann Bienz
LMB Division - Protein and Nucleic Acid Chemistry
Molecular mechanisms of Wnt signal transduction

The Wnt signalling pathway controls animal development and tissue homeostasis, and is also a major cancer pathway. Its key effector is β-catenin, which is stabilized in response to Wnt stimulation; it thus binds to TCF factors in the nucleus, and functions as a co-activator to mediate Wnt-induced transcription. Inappropriate activation of β-catenin can cause cancer in many human tissues, most notably colorectal cancer. More…

Mark van Breugel
LMB Division - Structural Studies
Structure and assembly mechanisms of centrioles

Centrioles are large and complex cell organelles that form the core of centrosomes and are essential for templating cilia and flagella. These structures are important for many cellular functions like cell division, fluid movement, motility, and sensing. Thus, it is not surprising that centriole dysfunction is associated with many human diseases like microcephaly, ciliopathies and probably cancer and infertility. More…

John Briggs
LMB Division - Structural Studies
Enveloped viruses and coated vesicles - cryo-electron microscopy and tomography

We study the structure and the molecular assembly mechanisms of important, pathogenic, enveloped viruses (e.g. HIV and Influenza virus), and of cellular trafficking vesicles (e.g. clathrin and COPI coated vesicles). More…

Simon Bullock
LMB Division - Cell Biology
Mechanisms of mRNA localisation and cytoskeletal transport

Molecular motors have critical roles in trafficking of organelles and macromolecules within the cytoplasm, and aberrant motor function has been implicated in diseases such as neurodegeneration. More…

Andrew Carter
Andrew Carter
LMB Division - Structural Studies
The structure and mechanism of dynein

The contents of eukaryotic cells are organised and moved around by motor proteins running along the tracks that make up the cytoskeleton (microtubules and actin filaments). The largest and most complicated of these is the microtubule motor cytoplasmic dynein. More…

Jason Chin
LMB Division - Protein and Nucleic Acid Chemistry
Systematic genetic code reprogramming / Centre for chemical and synthetic biology

Biomolecules and their dynamic assemblies, in collaboration with the energy provided by NTP hydrolysis, perform a spectacular range of mechanical and chemical manipulations on nanometre scale objects in the cell; molecular motors perform mechanical work, while enzymes rearrange atoms in ways, and at rates that synthetic chemists have difficulty emulating. More…

Gerry Crossan
LMB Division - Protein and Nucleic Acid Chemistry
Maintenance of genome stability in stem cells

The repair of damaged DNA is essential in all cells to ensure that the fidelity of the genome is maintained and to prevent mutations arising. This is of particular importance in stem cells, as mutations will not only effect that individual cell but the many millions of progeny derived from it. More…

Mario de Bono
LMB Division - Cell Biology
Genes, circuits and behaviour

Brains are highly parallel information processors. Their neural circuits continuously integrate sensory inputs to generate appropriate behavioural responses. More…

Emmanuel Derivery
LMB Division - Cell Biology
Mechanisms of asymmetric trafficking

Our goal is to establish the molecular mechanisms that generate cytoskeletal asymmetries during asymmetric cell division and to determine how, in turn, these cytoskeletal asymmetries generate polarized trafficking/signaling during development. More…

Alan Fersht
LMB Division - Protein and Nucleic Acid Chemistry
Tumour suppressor p53 structure and drug discovery

We use an amalgam of protein engineering, structural biology, biophysics and chemistry to study the structure, activity, stability and folding of proteins, and the role of protein misfolding and instability in cancer and disease. We focus on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53, in order to design novel anti-cancer drugs that function by restoring the activity of mutated proteins. More…

Paula da Fonseca
LMB Division - Structural Studies
Structure and function of cell regulatory protein complexes

In all living cells homeostasis, growth and division are critically regulated by highly specialised large multi-subunit protein complexes. Disruptions in these regulatory complexes result in cell malfunctioning and are frequently implicated in diseases such as cancer. More…

Rene Frank
René Frank
LMB Division - Neurobiology
Molecular architecture of the postsynaptic membrane

The ‘wiring’ of neuronal circuits in the mammalian brain is mediated by synapses, which are responsible for processing and storing information. We are interested in understanding the native molecular architecture of synapses with a particular focus on postsynaptic membranes that contain N-methyl D-aspartic acid receptors (NMDARs). More…

Michael Gait
LMB Division - Protein and Nucleic Acid Chemistry
Therapeutic applications of synthetic oligonucleotide analogues & their peptide conjugates

Our work focuses on the chemical synthesis of modified oligonucleotides, siRNA, peptide nucleic acids (PNA), and their peptide conjugates to target essential RNA structures inside cells for a variety of potential therapeutic applications. More…

Michel Goedert
LMB Division - Neurobiology
Molecular mechanisms of neurodegeneration

Alzheimer’s disease and Parkinson’s disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in several related disorders. The events leading to filament formation or the mere presence of filaments are believed to produce nerve cell degeneration. More…

Julian Gough
Julian Gough
LMB Division - Structural Studies
Computational Genomics

Medical research, and the molecular biology that it relies on, can be advanced in many ways using theoretical and computational approaches, mostly by harnessing the power of small and big data generated by experimental methods. More…

Ingo Greger
LMB Division - Neurobiology
AMPA receptor biogenesis, structure and function

Information transfer in the nervous system occurs at synapses where presynaptic signals are interpreted by postsynaptic receptors. We study this process with a focus on AMPA-type glutamate receptors, at various levels of complexity. More…