LMB Group Leaders - T to Z
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Chris Tate |
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| LMB Division: |
Structural Studies |
| Research: |
Structural Biology of integral membrane proteins |
| Summary: |
Integral membrane proteins are fundamental to a cells survival, allowing the import of nutrients, the export of toxins and intercellular communication via receptors. We aim to understand the processes of solute translocation and receptor signalling processes by determining the structures of important and interesting membrane proteins by x-ray crystallography. More... |
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Sarah Teichmann |
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| LMB Division: |
Structural Studies |
| Research: |
Computational Genomics |
| Summary: |
The wealth of genome-scale data now available for sequences, structures and interactions provides an unprecedented opportunity to systematically investigate principles of gene and protein interactions. We are particularly interested in the evolution and dynamics of regulatory and physical interaction networks. More... |
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Jernej Ule |
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| LMB Division: |
Structural Studies |
| Research: |
Post-transcriptional regulatory networks |
| Summary: |
The human genome encodes over five hundred RNA binding proteins, with potential to regulate alternative pre-mRNA splicing, mRNA translation and other aspects of post-transcriptional regulation. Little is known about the way these proteins regulate their target RNAs. More... |
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Alan Warren |
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| LMB Division: |
Protein and Nucleic Acid Chemistry |
| Research: |
Ribosome biogenesis and cancer |
| Summary: |
The synthesis of functional ribosomes is a critical process for all eukaryotic cells, but the underlying molecular mechanisms remain poorly understood. An exciting body of recent data indicates that mutations in genes with critical functions in ribosome biogenesis can cause bone marrow failure and leukaemia. More... |
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Roger L. Williams |
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| LMB Division: |
Protein and Nucleic Acid Chemistry |
| Research: |
Structural studies of phospholipid signalling |
| Summary: |
Most receptor-mediated signal transduction pathways in mammalian cells involve enzymes that generate either soluble or membrane-resident second messengers by modifying phospholipids present in cell membranes. More... |
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Group Leaders