T to Z
LMB Division - Structural Studies
Structural biology of integral membrane proteins
Integral membrane proteins are fundamental to a cell's survival, allowing the import of nutrients, the export of toxins and intercellular communication via receptors. We aim to understand the processes of solute translocation and receptor signalling processes by determining the structures of important and interesting membrane proteins by x-ray crystallography. More…
LMB Division - Neurobiology
Neural circuitry of action: from spatial perception to motor integration.
One of the major tasks that the nervous system faces is that of linking perception to action. We perceive the world around us through our senses and we use this information to select the most appropriate set of actions. More…
LMB Division - Structural Studies
Post-transcriptional regulatory networks
The human genome encodes over five hundred RNA binding proteins, with potential to regulate alternative pre-mRNA splicing, mRNA translation and other aspects of post-transcriptional regulation. Little is known about the way these proteins regulate their target RNAs. More…
LMB Division - Protein and Nucleic Acid Chemistry
Structural studies of phospholipid signalling
Most receptor-mediated signal transduction pathways in mammalian cells involve enzymes that generate either soluble or membrane-resident second messengers by modifying phospholipids present in cell membranes. More…