T to Z

Chris Tate
LMB Division - Structural Studies
Structure determination of integral membrane proteins

Integral membrane proteins are fundamental to a cell's survival, allowing the import of nutrients, the export of toxins and intercellular communication via receptors. We aim to understand the processes of solute translocation and receptor signalling processes by determining the structures of important and interesting membrane proteins by x-ray crystallography. More…

Rebecca Taylor
LMB Division - Neurobiology
Systemic control of proteostasis and ageing

The ageing process is accompanied by a cellular accumulation of misfolded proteins. These misfolded proteins lead to the onset of many diseases associated with old age, including neurodegenerative and metabolic disorders such as Alzheimer’s disease, Parkinson’s disease, and diabetes. More…

Marco Tripodi
LMB Division - Neurobiology
Neural circuitry of action: from spatial perception to motor integration.

One of the major tasks that the nervous system faces is that of linking perception to action. We perceive the world around us through our senses and we use this information to select the most appropriate set of actions. More…

Roger Williams
LMB Division - Protein and Nucleic Acid Chemistry
Structural studies of phospholipid signalling

Most receptor-mediated signal transduction pathways in mammalian cells involve enzymes that generate either soluble or membrane-resident second messengers by modifying phospholipids present in cell membranes. More…

Joseph Yeeles
Joseph Yeeles
LMB Division - Protein and Nucleic Acid Chemistry
Mechanisms of chromosome replication

Precise chromosome replication is essential for maintaining genome stability, yet the process itself is inherently risky. Duplex DNA must be transiently separated into unstable single-strands; a vast number of DNA bases must be accurately copied; and replication forks frequently encounter protein barriers and unrepaired DNA damage. More…