Recent Publications

2017

Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP. (2017) Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated. Cell 169:1303-1314

Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM. (2017) Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Elife e25174

Hoang HT, Schlager MA, Carter AP, Bullock SL. (2017) DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein-dynactin-cargo adaptor complexes. Proc Natl Acad Sci U S A 114:E1597-E1606

2016

Belyy V, Schlager MA, Foster H, Reimer AE, Carter AP, Yildiz A.(2016) The mammalian dynein-dynactin complex is a strong opponent to kinesin in a tug-of-war competition. Nat Cell Biol.18:1018-24

Carter AP, Diamant AG, Urnavicius L.(2015) How dynein and dynactin transport cargos: a structural perspective. Curr Opin Struct Biol.37:62-70

2015

Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP‡. (2015) The structure of the dynactin complex and its interaction with dynein. Science 347:1441-1446

Schmidt H*, Zalyte R*, Urnavicius L, Carter AP‡. (2015) Structure of human cytoplasmic dynein-2 primed for its power stroke. Nature 518:435-8 (pdf)

2014

Schlager MA*, Hoang HT*, Urnavicius L, Bullock SL‡, Carter AP‡. (2014) In vitro reconstitution of a highly processive recombinant human dynein complex. EMBO J. 33:1855-68 (pdf)

Gleave ES, Schmidt H, Carter AP‡. (2014) A structural analysis of the AAA+ domains in Saccharomyces cerevisiae cytoplasmic dynein. J Struct Biol. 186:367-75 (pdf)

2013

Carter AP‡. (2013) Crystal clear insights into how the dynein motor moves. J Cell Sci. 126:705-13 (pdf)

2012

Schmidt H, Gleave ES, Carter AP‡. (2012) Insights into dynein motor domain function from a 3.3-Å crystal structure. Nature Structure and Molecular Biology 19:492-7 (pdf)

2011

Carter AP*‡, Cho C*, Jin L, Vale RD‡. (2011) Crystal structure of the dynein motor domain. Science 331:1159-65 (pdf)

2009

Houdusse A‡, Carter AP‡. (2009) Dynein swings into action. Cell 136:395-6 (pdf)

2008

Carter AP*, Garbarino JE*, Wilson-Kubalek EM, Shipley WE, Cho C, Milligan RA, Vale RD, Gibbons IR. (2008) Structure and functional role of dynein's microtubule-binding domain. Science 322:1691-5 (pdf)

2007

Gennerich A, Carter AP, Reck-Peterson SL, Vale RD. (2007) Force-induced bidirectional stepping of cytoplasmic dynein. Cell 131:952-65 (pdf)

2006

Reck-Peterson SL, Yildiz A*, Carter AP*, Gennerich A, Zhang N, Vale RD (2006) Single-molecule analysis of dynein processivity and stepping behavior. Cell 126:335-48 (pdf)

2005

Gibbons IR, Garbarino JE, Tan CE, Reck-Peterson SL, Vale RD and Carter AP (2005). The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk. J Biol Chem 280: 23960-23965. (pdf)


* Joint authorship

‡ Corresponding author(s)