Research
A longstanding interest of the lab has been understanding the mechanisms by which mutations arise in the DNA of somatic cells through a process known as translesion synthesis. More recently, we have found that one of the key enzymes involved in translesion synthesis, Rev1, is also required for effective replication of DNA sequences that can form structures called G-quadruplexes and that loss of Rev1 leads to epigenetic instability in the vicinity of G-quadruplex motifs. Click on the links below to find out more.
