Publications

Pierrat, O., Strisovsky, K., Christova, Y., Large, J., Ansell, K., Bouloc, N., Smiljanic, E., and Freeman, M. (2011). Monocyclic beta-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases. ACS Chem Biol. 6, 325-335.

Escudero, L. M., da, F. C., Luciano, Kicheva, A., Briscoe, J., Freeman, M., and Babu, M. M. (2011). Epithelial organisation revealed by a network of cellular contacts. Nat Comms 2, 526.

Zettl, M., Adrain, C., Strisovsky, K., Lastun, V., and Freeman, M. (2011). Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling Cell 145, 79-91.

Adrain, C., Strisovsky, K., Zettl, M., Hu, L., Lemberg, M. K., and Freeman, M. (2011). Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep. 12, 421-427.

Aldaz, S., Escudero, L. M., and Freeman, M. (2010).  Live imaging of Drosophila imaginal disc development Proc. Natl. Acad. Sci. USA 107, 14217-14222.

Strisovsky, K., Sharpe, H. J., and Freeman, M. (2009). Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates. Mol. Cell. 36, 1048-1059.

Vinothkumar, K. R., Strisovsky, K., Andreeva, A., Christova, Y., Verhelst, S., and Freeman, M. (2010). The structural basis for catalysis and substrate specificity of a rhomboid protease. EMBO J. 29, 3797-3809.

Freeman, M. (2009). Rhomboids: 7 years of a new protease family. Semin. Cell. Dev. Biol. 20, 231-239.

Mao, Y., and Freeman, M. (2009). Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling. Development 136, 473-481.

Blobel, C. P., Carpenter, G., and Freeman, M. (2009). The role of protease activity in ErbB biology. Exp Cell Res 315, 671-682.