1. Compartmentalized self-replication (CSR);    1.1 Compartmentalized          self-replication.    1.2 Directed evolution of          polymerases by CSR.    1.3 Molecular cooperation and          coevolution in CSR. 2. A bacterial one-hybrid system. 3. A bacterial two-hybrid system.    3.1 Extracellular protein-protein          interactions.    3.2 Avidity-capture as a strategy          for the screening and          selection of extracellular          protein-protein interactions.    3.3 Importance of multivalency:          the chelate effect.    3.4 Detection of cognate          receptor-ligand interactions          using SAC.    3.5 Rapid selection of          antibody-antigen interactions          using SAC.    3.6 SAC applications in          molecular evolution and          genomics. 4. Past Projects Antibody engineering: Diabodies. Phage display: g3p and phage infection. E.coli mutator strains.
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