2002
deWildt R.M.T, Tomlinson I.M., Ong J.L. and
Holliger P. (2002)
Isolation of receptor-ligand pairs by capture of long-lived multivalent interaction complexes.
Proc. Natl. Acad. Sci. USA, 99, 8530-8535.
Holliger P. (2002)
Expression of antibody fragments in Pichia pastoris.
Methods Mol Biol. 178, 349-357.
Blanco B, Holliger P and Alvarez-Vallina L. (2002)
Autocrine costimulation: tumor-specific CD28-mediated costimulation of T cells by in situ production of a bifunctional B7-anti-CEA diabody fusion protein.
Cancer Gene Ther. 3, 275-281.
2001
Ghadessy, F.G., Ong, J.L., and Holliger, P. (2001)
Directed evolution of polymerase function by compartmentalized self-replication.
Proc. Natl. Acad. Sci. USA, 93, 4552-4557.
2000
Tomlinson I. and Holliger P. (2000)
Methods for generating multivalent and bispecific antibody fragments.
Methods Enzymol, 326, 461-479.
1999
Holliger P., Manzke O., Hawkins R., Span M., Fleischmann B., Qinghua L., Diehl V., Cochet O., Winter G. and Bohlen H. (1999)
CEA-specific activation in colon carcinoma by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti-CEA bispecific fusion proteins.
Cancer Res, 59, 2909-2916.
Holliger P., Riechmann L. and Williams R.L. (1999)
Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9Å: evidence for conformational lability.
J. Mol. Biol.,288, 649-657.
Manzke O.,Fitzgerald K.J., Holliger P., Klock J., Span M., Fleischmann B., Hescheler J., Qinghua L., Johnson K.S., Diehl V., Hoogenboom H.R. and Bohlen H. (1999)
Anti-CD3 x anti-nitrophenyl bispecific diabodies: universal immunotherapeutic tools for retargeting T-cells to tumors.
Int. J. Cancer, 82, 700-708.
Holliger, P. and Bohlen H. (1999)
Engineering antibodies for the clinic.
Cancer Metast. Rev. 18, 411-419.
1998
Holliger, P. and Hoogenboom, H. (1998)
Antibodies come back from the brink.
Nature Biotechnol. 16, 1015-1016.
1997
Holliger, P., Wing, M., Pound, J.D., Bohlen, H. and Winter G. (1997)
Retargeting serum immunoglobulin with bispecific diabodies.
Nature Biotechnol 15, 632-636.
Holliger, P. and Riechmann L. (1997)
A conserved infection pathway for filamentous bacteriophages is suggested by the structure of the membrane penetration domain of the minor coat protein g3p of phage fd.
Structure 5, 265-275.
Riechmann L. and Holliger, P. (1997)
The C-terminal domain of TolA is the coreceptor for filamentous phage infection of E.coli.
Cell 90, 351-360.
Fitzgerald K., Holliger, P. and Winter G. (1997)
Improved tumor targeting by disulfide-stabilised diabodies expressed in Pichia pastoris.
Protein Eng. 10, 1221-1225.
Pei, X.Y., Holliger, P., Murzin, A.G. and Williams, R.L. (1997)
The 2.0 Å resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3.
Proc. Natl. Acad. Sci. USA 94, 9637-9642.
Holliger, P. and Winter, G. (1997)
Diabodies: small bispecific antibody fragments.
Cancer Immunology Immunother. 45, 128-130.
Holliger, P. and Riechmann L. (1997)
Antibodies live long and prosper.
Nature Biotechnol. 15, 617.
1996
Holliger, P., Brissinck, J., Williams, R.L., Thielemans, K. and Winter, G. (1996)
Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody.
Protein Eng., 9, 299-305.
Low, N.M., Holliger, P. and Winter G. (1996)
Mimicking somatic hypermuation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain.
J. Mol. Biol., 260, 359-368.
1995
Holliger, P. and Hoogenboom, H. (1995)
Artificial antibodies and enzymes: Mimicking nature and beyond.
Trends Biotechnol., 13, 7-9.
1994
Peresics, O., Webb, P.A., Holliger, P., Winter, G. and Williams R.L. (1994)
Crystal structure of a diabody, a bivalent antibody fragment.
Structure 2, 1218-1226.
1993
Holliger, P., Prospero, T. and Winter, G. (1993)
Diabodies: small bivalent and bispecific antibody fragments.
Proc. Natl. Acad. Sci. USA, 90, 6444-6448.
Griffiths, A.D., Malmqvist, M., Marks, J.D., Bye, J.M., Embleton, M.J., McCafferty, J., Baier, M., Holliger, P., Gorick, B.D., Hughes-Jones, N.C., Hoogenboom, H.R. and Winter, G. (1993)
Human anti-self antibodies with high specificity from phage display libraries.
EMBO J. 12, 725-734.
Holliger, P. and Winter, G. (1993)
Engineering bispecific antibodies.
Curr. Op. Biotech. 4, 446-449.
1991 - 1992
Schein, Ch., Boix, E., Haugg, M., Holliger, P., Frank, G. and Schwalbe, H. (1992)
Expression of mammalian RNases in E.coli with the signal sequence of murine spleen RNase.
Biochem J., 283, 137-144.
Trautwein, K., Holliger, P., Stackhouse, J. and Benner, S.A. (1991)
Site-directed mutagenesis of bovine pancreatic ribonuclease: lysine 41 and aspartate-121.
FEBS-Lett., 281(1-2), 275-277
|
|
 |
|
