In vivo neuroimaging in C. elegans To fully understand behaviour at the molecular and cellular level, it is necessary
to determine how specific gene products affect the activity
of identified neurons, and to correlate the activity of these neurons
with behaviour.
We have developed methods that have allowed us to detect and
measure the activites of neurons and muscle cells using the
genetically-encoded indicator cameleon. We are
now using these imaging techniques in combination with traditional
C. elegans genetics to investigate the function, plasticity
and development
of specific neural circuits.
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