LMB In The News


John Sulston’s worm cell drawings

John Sulston is best known for the leading role he played in the Human Genome Project. But earlier in his career, while working at the LMB, he studied the development of the nematode worm. Sarah Harrop tells the story behind a lab notebook entry which contributed to a Nobel Prize-winning breakthrough. More...

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The revolution will not be crystallized: a new method sweeps through structural biology

“Move over X-ray crystallography. Cryo-electron microscopy is kicking up a storm by revealing the hidden machinery of the cell” – this Nature News Feature highlights the work of the LMB’s Richard Henderson, Nigel Unwin and Sjors Scheres in developing cryo-EM techniques that are changing the way scientists solve molecular structures. More…

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Orchestrating Organoids

Madeline Lancaster’s method of growing organoids to understand early brain development is featured in this “guide to crafting tissues in a dish that reprise in vivo organs” More…

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Worming our way to a new understanding of behaviour

The wriggling and writhing of worms may hold clues to the inner workings of our brains, according to scientists at the MRC’s Clinical Sciences Centre and their collaborators at the LMB. The researchers have developed a pioneering tool to analyse a worm’s posture as it wriggles, and will use the tool to investigate how exactly the worm’s brain controls its movements. More

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From tool to therapy: a timeline of monoclonal antibody technology

Abstract: They started out as a useful tool for studying the immune system in the lab and now they’re a family of drugs treating millions of patients, with global revenues of nearly $75 billion in 2013. MRC funding and researchers have been entwined with the monoclonal antibodies story from the very beginning. Forty years ago this month, Nature published a paper by the LMB’s César Milstein and Georges Köhler which described how they’d made mouse monoclonal antibodies. Here we look at the landmarks on the 40-year journey. More…

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The MORPHEUS II protein crystallization screen

Fabrice Gorrec from the LMB has published developments related to MORPHEUS II – a protein crystallization screen. He has demonstrated that additives selected from the PDB that are under-represented in traditional screens can be combined to formulate suitable and useful conditions, not only for crystallization but the overall structure determination process. More

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New details of the transmission of stimuli in living organisms unveiled

A team lead by Dmitry Veprintsev from the Paul Scherrer Institute (PSI) and ETH Zurich together with Madan Babu Mohan’s group at LMB and the pharmaceutical company Roche provide new details of how the activation of G-protein-coupled receptors takes place and demonstrate that only a few amino acids have a major influence on GPCR function. More…

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Monoclonal antibodies: the invisible allies that changed the face of medicine

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They are tiny magic bullets that are quietly shaping the lives of millions of patients around the world. Monoclonal antibodies are contained in six out of ten of the world’s bestselling drugs, helping to treat everything from cancer to heart disease to asthma. The technique for producing them was first published 40 years ago by César Milstein and Georges Köhler, at the LMB. More…

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The origin of biological clocks

Review of research, including that of the LMB’s John O’Neill, on the evolutionary story of circadian rhythms. More…

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Harnessing computer power to understand biology

In an interview for Science Careers, former LMB Group Leader Sarah Teichmann talks about how she was inspired by computational biology by Cyrus Chothia, with whom she did her PhD. She also shares how she gained her skills and abilities and what doors they opened to her. More…

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