LMB In The News


Did frosts lead to life on Earth?

Large RNA molecules can be assembled from basic biochemical building blocks during cycles of freezing and thawing. This breakthrough from Philipp Holliger’s group at the LMB reinforces the possibility that RNA was responsible for both molecular heredity and metabolism in primordial biochemistry. More…

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Making Sense of the Chemistry That Led to Life on Earth

An article in the New York Times highlights the work of John Sutherland, a group leader at the LMB, who has determined a possible chemical pathway to produce the starting materials of life. In his laboratory he tested all the chemical reactions needed to make precursors of lipids, nucleotides and amino acids, the building blocks of life, and developed evidence that these could occur under the conditions expected of primitive Earth. More…

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Towards preventing neurodegenerative diseases

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Research led by the LMB’s Anne Bertolotti has discovered a selective inhibitor of a phosphatase enzyme that could prevent protein misfolding diseases. The scientists showed that the new molecule, dubbed Sephin1, countered the effects of aggregating proteins in mouse models of amyotrophic lateral sclerosis and Charcot-Marie-Tooth disease, and might do so for other neurodegenerative disorders. More…

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Mechanism-based therapeutics of common human neurodegenerative diseases

The LMB and the Department of Clinical Neurosciences have announced an initiative in mechanism-based therapeutics of common human neurodegenerative diseases. This initiative, developed by Michel Goedert and Alastair Compston, aims to identify core mechanisms of protein aggregation and spreading in neurodegeneration, and to apply that knowledge to study putative new therapies. More…

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First pictures of the mitoribosome taken

Chemical & Engineering News (C&EN)

Researchers, including a team from the LMB, have obtained structures of complete ribosomes from mammalian mitochondria at near-atomic resolution for the first time. More…

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Body clock expert talks to students

Michael Hastings delivers sixth form lecture at King William’s College, Isle of Man, on his research into circadian rhythms and biological clocks. More…

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Image of the Week: Structure of the dynactin complex

The structure of the dynactin complex, solved by Andrew Carter’s group at the LMB, is the cover story on this week’s Science and is the Wellcome Trust’s Image of the week. The picture shows a model of the dynein/dynactin protein machine that moves cargo around the cell, that was determined using electron cryo-microscopy. More…

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David Komander part of collaborative consortium in the field of deubiquitinating enzymes.

FORMA Therapeutics and Cancer Research Technology, Ltd (CRT) have announced the formation of two new virtual Asset Discovery and Development Companies (ADDCos) to represent the collective efforts of the consortium in the field of deubiquitinating enzymes (DUBs). ADDCos are virtual companies seeking to achieve rapid innovation in a compelling scientific area through the collaboration of academic thought leaders, FORMA drug discovery scientists and a world class development network. More…

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Biologist Venki Ramakrishnan to lead Royal Society

The next president of the Royal Society will be the Nobel-winning LMB researcher Venki Ramakrishnan. He will succeed Paul Nurse in December 2015. After hearing of the confirmation, Venki told the BBC News that he was “very honoured” to be the society’s president elect. More…

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Reaction map suggests meteorite chemistry route to life

LMB scientists have found a reaction network that they believe shows that ‘pretty much everyone’ working on life’s molecular origins is wrong – but also ‘right, in a sense’. Until now, the field has warred over which biomolecule, emerged first. But John Sutherland’s group found the different types may have appeared simultaneously. More…

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