LMB In The News

Trim-Away: a new technique for depleting proteins and studying their function

Dean Clift from Leo James’ group, in collaboration with LMB alumnus Melina Schuh at the Max Planck Institute, have developed a new technique – Trim-Away – which allows proteins to be rapidly depleted from cells. By harnessing the cells’ protein degradation machinery and TRIM21, the scientists have provided a new technique for studying protein function. More…


Finding the founding fathers of molecular biology – a blog post by LMB PhD student, Lisa Strittmatter

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Lisa Strittmatter, PhD student in the LMB’s Structural Studies Division, explores a recent talk given at the LMB by Professor Sir John Meurig Thomas, and the light it sheds on the key scientists involved in the origins of molecular biology. More…


Brain research in the third dimension

Madeline Lancaster, cell biologist at the MRC Laboratory of Molecular Biology in Cambridge, has developed a technique allowing her to create mini brains from cell cultures. These incredible organoids, no larger than the eraser at the end of a pencil, serve as a model for Madeline’s research into early human brain development and are enabling Madeline and her team to tackle the age-old question: what is it that distinguishes us as humans? More…


LMB scientist wins ‘Best Technology’ prize in the 2017 Biomaker Challenge

The LMB’s Wolfgang Schmied, in collaboration with Stéphanie Polderdijk from the Cambridge Institute for Medical Research, won ‘Best Technology’ prize in the 2017 Biomaker Challenge for developing a low-cost chromatography system for protein purification. The Challenge aims to show the value of open, low-cost and DIY technologies as convening points for interactions between biologists and engineers. More…


BBC: Daytime wounds ‘heal more quickly’

A new study led by John O’Neill and Ned Hoyle shows how bodyclocks in skin cells influence wound healing. More…


Using cryo-EM to solve the structure of a protein complex critical for gene expression

Lori Passmore and her group have used cryo-electron microscopy to solve the structure of CPF, a protein complex critical for gene expression. Understanding the structure and function of intact CPF, and how it is assembled, has been a central question in the field of gene expression for decades. More…


PINK1 caught on the brink of phosphorylation

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Scientists have caught a rare view of an unusual kinase poised to phosphorylate its substrate. Led by David Komander, MRC Laboratory of Molecular Biology in Cambridge, England, U.K., the researchers reported the crystal structure of the kinase PINK1 bound to ubiquitin in the October 30 Nature.  “We captured a pre-catalytic state, a snapshot of PINK1 holding ubiquitin before the phosphate group jumps on,” said first author Alexander Schubert. More…


Fundamental rules for how the brain controls movements

Using the nematode as one test system, scientists at CCNR have spent the past several years understanding how a network controls itself—for instance, which individual neurons in the worm’s brain are in charge of a backward wiggle. In research published in Nature, they describe for the first time their ability to predict, test, and confirm with unprecedented detail how a nematode’s brain controls the way it moves.  Colleagues from Bill Schafer’s group at the LMB tested the predictions by killing individual neurons from the nematode brain with a laser.  They then measured the effects of these “microsurgeries” on behaviour. More…


Researchers “drug the undruggable”


A new approach to targeting key cancer-linked proteins, thought to be ‘undruggable’, has been discovered through an alliance between industry and academia created by Cancer Research UK.  David Komander’s group in the LMB is one of the groups involved in this unique collaboration, that shows that two novel and specific small-molecule inhibitors developed by the alliance can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. This deactivation allows p53 to be turned on, putting the brakes on cancer growth. More…


The birth of the cool

Super cool microscopy wins the 2017 Nobel prize in chemistry: includes interview with LMB’s Richard Henderson. More…