LMB In The News

Researchers “drug the undruggable”


A new approach to targeting key cancer-linked proteins, thought to be ‘undruggable’, has been discovered through an alliance between industry and academia created by Cancer Research UK.  David Komander’s group in the LMB is one of the groups involved in this unique collaboration, that shows that two novel and specific small-molecule inhibitors developed by the alliance can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. This deactivation allows p53 to be turned on, putting the brakes on cancer growth. More…


The birth of the cool

Super cool microscopy wins the 2017 Nobel prize in chemistry: includes interview with LMB’s Richard Henderson. More…


Cryo-electron microscopy wins chemistry Nobel

Jacques Dubochet, Joachim Frank and Richard Henderson were awarded the prize on 4 October for their work in developing cryo-electron microscopy (cryo-EM), a technique that fires beams of electrons at proteins that have been frozen in solution, to deduce the biomolecules’ structure. More…


Richard Henderson shares 2017 Nobel Prize in Chemistry

The Nobel prize in chemistry has been awarded to three scientists, Jacques Dubochet, Joachim Frank and the LMB’s Richard Henderson, for developing a technique to produce images of the molecules of life frozen in time.  The technique, called cryo-electron microscopy, allowed biomolecules to be visualised in their natural configuration for the first time, triggering a “revolution in biochemistry”, according to the Nobel committee. The latest versions of the technology mean scientists can record biochemical processes as they unfold in film-like sequences. More…


Leprosy turns the immune system against itself

An international team of scientists, including Lalita Ramakrishnan’s group in the University of Cambridge Molecular Immunity Unit, based at the LMB, have discovered that Leprosy hijacks our immune system, turning an important repair mechanism into one that causes potentially irreparable damage to our nerve cells. More…


Protein localization inside cells

Ramanujan Hegde talks about protein localization inside cells and quality control of this process. More…


Tau filaments from the Alzheimer’s brain revealed

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Tau filaments isolated from an Alzheimer’s brain are the latest, high-profile exploit of cryo-electron microscopy. Crafting a technique that has become his claim to fame, Sjors Scheres of the MRC Laboratory of Molecular Biology in Cambridge, England, teamed up with Michel Goedert, also at MRC, to solve 3.4-Angstrom resolution structures of both straight and paired helical filaments of tau. The structures, first unveiled at the AD/PD meeting in Vienna last March, were formally published in Nature on July 5. More…


Exploring the incredible transport system inside our cells

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Simon Bullock discusses his research into intracellular trafficking of RNA, and talks about the importance of science outreach in inspiring the next generation of young scientists. More…


Sharp focus on Alzheimer’s may help target drugs

Abnormal deposits that build up in the brain during Alzheimer’s have been pictured in unprecedented detail in research led by Sjors Scheres and Michel Goedert. More…


G-protein coupled receptors as drug targets: Heptares Therapeutics celebrates its tenth anniversary

Chris Tate – co-founder of Heptares Therapeutics, a company established to commercialise research from the LMB – discusses his work on G-protein coupled receptors. More…