| RECENT MAJOR PUBLICATIONS OF THE GROUP | |||||||
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Protein-induced conformational changes of RNA during the assembly of human signal recognition particle. Menichelli, E., Isel, C., Oubridge, C. and Nagai, J. Mol. Biol. (2007) in press Gemin 6 and 7 lend a hand to snRNP assembly. Leung, A. K. and Nagai, K. Structure 13, 833-834 (2005). Structural basis of the interaction between P-element somatic inhibitor and U1-70k essential for the alternative splicing of P-element transposase. Ignjatovic, T., Yang, J.-C., Butler, J., Neuhaus, D. and Nagai, K. J. Mol. Biol. 351, 52-65 (2005). The structure and biochemical properties of the human spliceosomal protein U1C. Muto, Y., Pomeranz Krummel, D.A., Oubridge, C., Hernandez, H.,, Robinson, C.V., Neuhaus, D., and Nagai, K. J. Mol. Biol. 341, 185-198 (2004). Crystallization of RNA-protein complexes. Obayashi, E., Oubridge, C., Pomeranz Krummel, P. and Nagai, K. Book edited by Sylvie Doublee and John Walker (2004) in press Induced structural changes of 7SL RNA during assembly of the human signal recognition particle. Kuglstatter, A., Oubridge, C. and Nagai, K. Nature Struct. Biol. 9, 740-744 (2002). Crystal Structure of SRP19 in Complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle. Oubridge, C., Kuglstatter, A., Jovine, L. and Nagai, K. Molec. Cell 9, 1251-1261(2002). Stoichiometry of the Sm proteins in yeast spliceosomal snRNPs supports the heptamer ring model of the core domain. Walke, S., Bragado-Nilsson, E., Seraphin, B. and Nagai, K. J. Mol. Biol. 308, 49-58 (2001) Crystal structure of the Ffh andEF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA. Jovine, L., Hainzl, T., Oubridge, C., Scott, W. G., Li, J., Sixma, T. K., Wonacott, A., Skarzynski, T. and Nagai, K. Structure 8, 527-540 (2000) Structure and Assembly of the spliceosomal small nuclear ribonucleoprotein particles. Kambach, C., Walke, S. & Nagai, K. Curr. Opin. Structural Biology 9, 222-230 (1999). The structure of two core snRNP protein complexes and their implications to the assembly of snRNPs. Kambach, C., Walke, S., Young, R., Avis, J. M., de la Fortelle, E., Raker, V., Luhrmann, R., Li, J. & Nagai, K. Cell 96, 375-387 (1999). Crystal structure of the spliceosomal U2B" and U2A' proteins bound by a U2 snRNA fragment. Price, S. R., Evans, P. R. & Nagai, K. Nature 394, 645-650 (1998). RNA recognition by RNP proteins during RNA processing. Varani, G. & Nagai, K. Annu. Rev. Biophys. Biomol. Struct. 27, 407-445 (1998). Two Structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy. Jovine, L., Oubridge, C., Avis, J.M. & Nagai, K. Structure 4, 621-631 (1996). Determination of ribonucleoprotein specificity by RNA folding during complex formation. Allain, F.H.-T., Gubser, C.C., Howe, P.W.A., Nagai, K., Neuhaus, D. & Varani, G. Nature 380, 646-650 (1996). Solution structure of the N-terminal RNP domain of U1A protein: the role of the C-terminal residues in structure stability and RNA binding. Avis, J.M., Allain, F.H.-T., Howe, P., Varani, G., Nagai, K. & Neuhaus, D. J. Mol. Biol. 257, 398-411 (1996). Crystallization of RNA-Protein Complexes: I. Methods for the large-scale preparation of RNA suitable for crystallographic studies. Price, S.R., Ito, N., Oubridge, C., Avis, J.M. & Nagai, K. J. Mol. Biol. 249, 398-408 (1995). Crystallisation of RNA-protein Complexes: II. The application of Protein Engineering for Crystallisation of the U1A Protein-RNA Complex. Oubridge, C., Ito, N., Teo, C.-H., Fearnly, I. & Nagai, K. J. Mol. Biol. 249, 409-423 (1995). The RNP domain: a sequence-specific RNA-binding Domain involved in procession and transport of RNA. Nagai, K., Oubridge, C., Ito, N., Avis, J. & Evans, P. TIBS 20, 235-240 (1995). Transplanting a Unique Allosteric Effect from Crocodile into Human Haemoglobin. Komiyama, N.H., Miyazaki, G., Tame, J. & Nagai, K. Nature 373, 244-246 (1995). NMR Studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. Howe, P.W.A., Nagai, K., Neuhaus, D. & Varani, G. EMBO J. 13, 3873-3881 (1994). Crystal structure at 1.92 A resolution of the RNA binding domain of the U1A protein complexed with an RNA hairpin. Oubridge, C., Ito, N., Evans, P.R., Teo, C.-H. & Nagai, K. Nature 372, 432-438 (1994). A human recombinant hemoglobin designed for use as a blood substitute. Looker, D., Abbott-Brown, D., Cozart, P., Durfee, S., Hoffman, S., Mathews, A.J., Miller-Roehrich, J., Shoemaker, S., Trimble, S., Fermi, G., Komiyama, N.H., Nagai, K. & Stetler, G.L. Nature 356, 258-260 (1992). Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. Jessen, T.-H., Oubridge, C., Teo, C.H., Pritchard, C. & Nagai, K. EMBO J. 10, 3447-3456 (1991). Was the loss of the D helix in a globin a functionally neutral mutation? Komiyama, N.H., Shih, D.T.-B., Looker, D., Tame, J. & Nagai, K. Nature 352, 349-351 (1991). Phase determination using mercury derivatives of engineered cysteine mutants. Nagai, K., Evans, P.R., Li, J. & Oubridge, C. Proc. CCP4 study Weekend (Evans, P.R. & Leslie, A., eds), pp. 141-149, SERC Daresbury Laboratory, UK (1991). Crystal structure of the U1 small nuclear ribonucleoprotein A. Nagai, K., Oubridge, C.J., Jessen, T.-H., Li, J. & Evans, P.R. Nature 348, 515-520 (1990). Sequence-specific [1H] NMR resonance assignments and secondary structure identification for 1- and 2-zinc finger constructs from SWI5: A hydrophobic core involving four invariant residues. Neuhaus, D., Nakaseko, Y., Nagai, K. & Klug, A. FEBS letters 262, 179-184 (1990). |
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| Book | |||||||
| RNA-protein Interactions. Nagai, K. & Mattaj, I. W. (eds). Oxford University Press (1994). | |||||||