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  • Author: [Cambridge News]
    Title: The British Scientist, Dr H. C. Watson holds a model of a protein molecule
    Reference [Cambridge News]
    Year: [date unknown]
    Type: Science
    Subject: H. C. Watson lecturing at the Biophysical Society, New York, on proteins
    Keywords: H. C. Watson
    Photographs: H. C. Watson and model of a protein molecule


  • Author: Veitch, Andrew
    Title: Leading brain research centre to close
    Reference The Guardian, [date unknown]
    Year: [c. mid 1980s]
    Type: Funding
    Subject: The MRC plans to close the neurochemical pharmacology unit at Cambridge University Medical School
    Keywords: John Butterfield; Leslie Iverson; Angus Mackay; Neurochemical Pharmacology Unit
    Photographs:


  • Author: Veitch, Andrew
    Title: Job puzzle at doomed brain unit
    Reference The Guardian, [date unknown]
    Year: [c. mid 1980's]
    Type: Funding
    Subject: Staff at the Neurochemical Pharmacology Unit have been told it is to close because a new director has not been found
    Keywords: Piers Emson; Leslie Iversen; Neurochemical Pharmacology Unit
    Photographs:


  • Author: Devlin, Hannah
    Title: Alcohol can cause irreversible genetic damage to stem cells, says study
    Reference The Guardian 3 January 2018
    Year: 2018
    Type: Science
    Subject: Link between drinking and cancer clarified by study – led by KJ Patel’s group in the LMB’s PNAC Division – which indicates alcohol causes cancer by scrambling DNA in cells, eventually leading to mutations.
    Keywords: KJ Patel; alcohol; cancer; acetaldehyde; DNA damage; aldehyde dehydrogenase 2 (ALDH2); flushing mutation; stem cells; blood cells
    Photographs:


  • Author: Brackley, Paul
    Title: Magnetic attraction of AstraZeneca to MRC Laboratory of Molecular Biology
    Reference Cambridge Independent 8 January 2018
    Year: 2018
    Type: Biotechnology
    Subject: AstraZeneca has moved its Nuclear Magnetic Resonance laboratory to the LMB while its new global R&D centre is built nearby.
    Keywords: AstraZeneca; Maria Flocco; nuclear magnetic resonance (NMR); Hugh Pelham; David Neuhaus; Kevin Embrey; superconducting solenoid; Blue Skies; PAR; cancer; drug discovery; cryo-electron microscopy; consortium
    Photographs: David Neuhaus, and Kevin Embrey in the nuclear magnetic resonance (NMR) lab


  • Author: Davies, Emma
    Title: The rhythm of life
    Reference Education in Chemistry 11 January 2018
    Year: 2018
    Type: Science
    Subject: John O’Neill, from Cell Biology Division, discusses how unravelling the complex mechanisms of the body clock has led to some fascinating discoveries worthy of the 2017 Nobel Prize in Physiology or Medicine.
    Keywords: circadian rhythms; John O’Neill; Jeffrey Hall; Michael Rosbash; Michael Young; clock genes; PER; TIM protein; jet lag; suprachiasmatic nucleus (SCN)
    Photographs:


  • Author: Arney, Kat
    Title: Unlocking the secrets of the brain - From autism and schizophrenia to Alzheimer’s lab-grown mini-brains could be the key to solving the biggest mysteries about human development and disease
    Reference Science Focus 5 January 2018
    Year: 2018
    Type: Science
    Subject: Madeline Lancaster, from the LMB’s Cell Biology Division, discusses how lab-grown ‘mini-brains’ could be the key to solving the biggest mysteries about human brain development and disease.
    Keywords: Madeline Lancaster; ‘mini-brain’; organoids; brain stem cells; ‘rosettes’; ‘black box’; ‘brain Lego’; epilepsy; Alzheimer’s disease; telomeres; autism
    Photographs:


  • Author: International Society for Computational Biology (ISCB)
    Title: 2018 ISCB Innovator Award M. Madan Babu
    Reference ISCB 15 February 2018
    Year: 2018
    Type: Awards & Prizes
    Subject: The Award is given to a leading scientist who is within a decade and half of receiving their PhD degree, and has consistently made outstanding contributions to the field and continues to forge new directions.
    Keywords: Award; Madan Babu; ISCB innovator award; cellular regulation; signalling proteins;
    Photographs: Portrait of Madan


  • Author: Brackley, Paul
    Title: Dr Jan Löwe says he’s ‘humbled’ to take over as director of MRC Laboratory of Molecular Biology
    Reference Cambridge Independent 14 February 2018
    Year: 2018
    Type: Events and Celebrations
    Subject: Deputy Director, Jan Löwe, will be taking over from Hugh Pelham as Director of the LMB this spring
    Keywords: Jan Löwe; new director; Hugh Pelham; “excited and humbled”; ‘Nobel Prize factory’; Richard Henderson
    Photographs: Jan Löwe (LMB); Hugh Pelham (LMB); Building; Hugh Pelham with Richard Henderson; picture of crowds on an open day


  • Author: Knapton, Sarah
    Title: Alzheimer’s disease will become manageable like HIV, say award-winning scientists
    Reference The Telegraph 6 March 2018
    Year: 2018
    Type: Awards & Prizes
    Subject: 2018 Brain Prize winner Michel Goedert, group leader in the Neurobiology Division, who discovered the importance of tau protein in Alzheimer’s said he could see a time when dementia became a chronic illness like HIV.
    Keywords: Michel Goedert; Brain Prize; tau protein; Alzheimer’s; HIV; dementia; Lundbeck Foundation; amyloid; neurodegenerative disease; John Hardy; Bart De Strooper; Christian Haass
    Photographs:


  • Author: University of Cambridge - Department of Zoology
    Title: Regulation of DNA replication during early embryogenesis
    Reference University of Cambridge 5 March 2018
    Year: 2018
    Type: Science
    Subject: Julian Sale and collaborators from the Francis Crick Institute and the Department of Zoology have discovered and characterised a new macromolecular protein complex that is essential for rapid DNA replication and cleavage cycles in very early embryos.
    Keywords: Julian Sale; Xenopus laevis; Y RNS’s; xNuRD; embryos; replications; mid-blastula transition (MBT)
    Photographs:


  • Author: Woodmansey, David
    Title: Biomarker offers new hope for foot-and-mouth detector
    Reference Vet Times 13 March 2018
    Year: 2018
    Type: Science
    Subject: A new discovery by David Komander’s group and collaborators could allow scientists to detect animals infected with the foot-and-mouth disease virus (FMDV) and distinguish them from those that have been vaccinated.
    Keywords: David Komander; foot-and-mouth disease virus (FMDV); The Pirbright Institute; diagnostics; test; antiviral signalling; biomarker; vaccination
    Photographs:


  • Author: Ferry, Georgina
    Title: Obituary - John Sulston (1942-2018)
    Reference Nature 19 March 2018
    Year: 2018
    Type: Obituary
    Subject: Nature looks back at the life and work of John Sulston, from his time investigating cell fate, lineage and the genetics of C. elegans at the LMB, to his involvement with the Human Genome Project.
    Keywords: John Sulston; Human Genome Project; caenorhabditis elegans; Francis Crick; Sydney Brenner; Robert Horvitz; worm; Sanger Centre; The Common Thread; sequencing; cell death; Jim Watson
    Photographs: John Sulston in lab


  • Author: Bobrowska, Anna
    Title: Cell scientist to watch - Madeline Lancaster
    Reference Journal of Cell Science 4 January 2017
    Year: 2017
    Type: Career Structure
    Subject: Madeline Lancaster, group leader in the LMB’s Cell Biology Division, is interviewed by the Journal of Cell Science and describes her impetus to pursue a career in science, discusses starting her own lab at the LMB and talks about her current research.
    Keywords: Madeline Lancaster; microcephaly; macrocephaly; mutations; in vitro; organoids; brain; 3D; epithelial-derived organs; mesoderm-derived tissues; tissue engineering
    Photographs: Madeline with the lab in the background; Madeline skiing in the U.S.


  • Author: Mukhopadhyay, Rajendrani
    Title: A chain of events: Linear ubiquitin chains, whose very existence once debated, now known to play a critical role in an inflammatory disease, thanks to the discovery of an enzyme
    Reference ASBMB Today 5 January 2017
    Year: 2017
    Type: Science
    Subject: David Komander’s group are amongst a group of scientists researching the enzymes of the ubiquitin system, which has already shown how mutations in the gene for OTULIN, an enzyme belonging to the OTU family of deubiquitinases, cause a rare systemic inflammatory disease
    Keywords: David Komander; Rune Damgaard; Andrew McKenzie; FAM105B; enzymes; OTULIN; ubiquitin; LUBAC; mutations; inflammation; deubiquitinase; Met1-linked chains; NF-κB
    Photographs:


  • Author: University of Cambridge Research
    Title: Dementia: Catching the memory thief
    Reference University of Cambridge Research News 18 January 2017
    Year: 2017
    Type: Science
    Subject: New film describing some of the progress now being made against this devastating disease, includes commentary from Michel Goedert, group leader in the Neurobiology Division, who discovered how tau fibres twist together to form tangles, a hallmark of Alzheimer’s, a type of dementia
    Keywords: Alzheimer’s disease; Michel Goedert; ‘dementia tsunami’; ‘tangles’; ‘plaques’; beta-amyloid; ‘neurostatins’; ‘memory thief’; nerodegenerative disease; European Grand Prix; ‘magic bullet’
    Photographs:


  • Author: Bowman Rogers, Madolyn
    Title: Antibodies Co-Opt Anti-Microbial Response to Clear Intraneuronal Tau
    Reference ALZFORUM 13 January 2017
    Year: 2017
    Type: Science
    Subject: Leo James and Michel Goedert, group leaders, recently published work in PNAS providing an explanation for how therapeutic antibodies eliminate pathogenic forms of tau protein. Here, Alzforum explore the background, results and implications of this study.
    Keywords: Michel Goedert; Leo James; TRIM21; tau; William McEwan; HEK293; antibodies; neuroblastoma cell line; SHSY-5Y; cytosolic protein; virus; PNAS
    Photographs:


  • Author: Wiley
    Title: The 16th Annual Wiley Prize in Biomedical Sciences Awarded for Pioneering Developments in Electron Microscopy
    Reference Wiley Newsroom 22 February 2017
    Year: 2017
    Type: Awards & Prizes
    Subject: The 16th annual Wiley Prize in Biomedical Sciences was awarded to Joachim Frank, Richard Henderson, and Marin van Heel for pioneering developments in electron microscopy that are transforming structural studies of biological molecules and their complexes
    Keywords: Joachim Frank; Richard Henderson; Marin van Heel; Wiley Foundation; electron microscopy; Wiley Prize; $50,000; The Rockefeller University; Biomedical Sciences
    Photographs:


  • Author: University of Cambridge
    Title: Life through a lens
    Reference Cambridge Science Festival 27 February 2017
    Year: 2017
    Type: Events and Celebrations
    Subject: Brad Amos gave a talk at the UTC Cambridge as part of the Cambridge Science Festival
    Keywords: Brad Amos; Cambridge Science Festival; 3D images; subcellular; Mesolens
    Photographs: Brad in the lab


  • Author: University of Cambridge
    Title: Finding the fountain of youth: why we age and what we can do about it
    Reference Cambridge Science Festival 28 February 2017
    Year: 2017
    Type: Events and Celebrations
    Subject: Rebecca Taylor gave a talk at the UTC Cambridge as part of the Cambridge Science Festival. Rebecca explains how her lab are using worms to understand how the nervous system coordinates the ageing process, and how it controls the health of cells as we get older
    Keywords: Rebecca Taylor; Cambridge Science Festival; nervous system; ageing process; worms; fountain of youth
    Photographs:


  • Author: Protein Data Bank in Europe
    Title: Bringing Artists and Scientists Together Creates Very Exciting Results
    Reference Protein Data Bank in Europe 6 March 2017
    Year: 2017
    Type: Exhibitions
    Subject: Vivian, student artist who created a painting based on lysenin during Protein Data Bank in Europe’s art-science collaborative project, met with LMB’s Christos Savva, the scientist who discovered the structure of lysenin
    Keywords: The Leys School; PDBe; lysenin; garden earthworm; art; Christos Savva; Michaelhouse Gallery; Vivian; 3D protein structures; exhibition; toxin; Protein Data Bank (PDB)
    Photographs: Vivian and Christos standing in front of her painting


  • Author: Mazur, Suzan
    Title: Julian Gough on SUPERFAMILY & Open Science
    Reference The Huffington Post 13 March 2017
    Year: 2017
    Type: Science
    Subject: Julian Gough is interviewed by the Huffington Post and discusses SUPERFAMILY, his database of structural and functional annotations for proteins and genomes, a public resource which scientists around the world can use freely in their research.
    Keywords: Julian Gough; SUPERFAMILY; genomes; Tree of Life; protein domains; Cyrus Chothia; Michael Levitt; BioEssays; Genetrainer; computational prediction; database; Alexey Murzin; Protein Data Bank (PDB); Max Perutz; myoglobin; protein x-ray crystallography; Structural Classification of Proteins (SCOP); viruses; InterPro database
    Photographs: Image of Julian Gough


  • Author: University of Cambridge Research
    Title: Visualising the genome: researchers create first 3D structure of active DNA
    Reference University of Cambridge Research News 16 March 2017
    Year: 2017
    Type: Science
    Subject: Tim Stevens, in collaboration with scientists from the University of Cambridge, has determined the first 3D structures of intact mammalian genomes from individual cells, showing how the DNA from all the chromosomes intricately folds to fit together inside the cell nuclei.
    Keywords: Mammalian genomes; 3D structures; ‘master cells’; chromosomes; Tim Stevens; Ernest Laue; nuclear lamina; nuclei
    Photographs:


  • Author: Cambridge News
    Title: PhD student Cara presents work to MPs
    Reference Cambridge News 15 March 2017
    Year: 2017
    Type: Events and Celebrations
    Subject: Cara Ellison a PhD student at the LMB takes part in the Stem (Science Technology, Engineering and Maths) for Britain event at Westminster
    Keywords: Cara Ellison; Westminster; PhD Student; Parliament; MPs; bacteria; viruses; shortlisted; Scientific Committee
    Photographs: Cara in the lab


  • Author: Medical Research Council
    Title: Researchers create first 3D structures of active DNA
    Reference Medical Research Council 13 March 2017
    Year: 2017
    Type: Science
    Subject: Scientists, have determined the first 3D structures of intact mammalian genomes from individual cells, showing how the DNA from all the chromosomes intricately folds to fit together inside the cell nuclei.
    Keywords: Mammalian genomes; 3D structures; ‘master cells’; chromosomes; Tim Stevens; Ernest Laue; nuclear lamina; nuclei
    Photographs:


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