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  • Author: [Cambridge News]
    Title: The British Scientist, Dr H. C. Watson holds a model of a protein molecule
    Reference [Cambridge News]
    Year: [date unknown]
    Type: Science
    Subject: H. C. Watson lecturing at the Biophysical Society, New York, on proteins
    Keywords: H. C. Watson
    Photographs: H. C. Watson and model of a protein molecule


  • Author: Veitch, Andrew
    Title: Leading brain research centre to close
    Reference The Guardian, [date unknown]
    Year: [c. mid 1980s]
    Type: Funding
    Subject: The MRC plans to close the neurochemical pharmacology unit at Cambridge University Medical School
    Keywords: John Butterfield; Leslie Iverson; Angus Mackay; Neurochemical Pharmacology Unit
    Photographs:


  • Author: Veitch, Andrew
    Title: Job puzzle at doomed brain unit
    Reference The Guardian, [date unknown]
    Year: [c. mid 1980's]
    Type: Funding
    Subject: Staff at the Neurochemical Pharmacology Unit have been told it is to close because a new director has not been found
    Keywords: Piers Emson; Leslie Iversen; Neurochemical Pharmacology Unit
    Photographs:


  • Author: Micro Control Instruments
    Title: Top Ten Neuroscience Breakthroughs of 2018
    Reference Micro Control Instruments 7 January 2019
    Year: 2019
    Type: Science
    Subject: A list of the top ten neuroscience breakthroughs of 2018 includes work by the LMB’s Sjors Scheres and Michel Goedert on tau protein folds and by Greg Jefferis on imaging the fly brain, as well as alumnus Jonny Kohl for his work mapping neural circuitry associated with parenting.
    Keywords: Tau protein; Alzheimer’s disease; Sjors Scheres; Michel Goedert; frontotemporal dementia; Cryo-electron microscopy; misfolded; Pick’s disease; fly brain imaged; nanoscale resolution; 3D volume; synaptic level; Johnny Kohl; alumni; galanin-expressing neurons; optogenetic tools; parental circuitry
    Photographs:


  • Author: Cookson, Clive
    Title: Brilliance in the genes: inside Britain’s ‘Nobel prize factory’
    Reference Financial Times 23 January 2019
    Year: 2019
    Type: Science
    Subject: A new film from the Financial Times featuring interviews with Jan Löwe, Madeline Lancaster, Richard Henderson, and Greg Jefferis, describing the importance of long-term thinking and collaboration in continued success.
    Keywords: Jan Löwe; Madeline Lancaster; Richard Henderson; Greg Jefferis; ‘Nobel prize factory; stem cells; mini-brains 3D neural tissues; neurological conditions; cryo-electron microscopy; amorphous ice; near-atomic structure; structure-based drug design; AstraZeneca; collaborate; connectome; Alzheimer’s disease; fly brain; neurons; Cambridge Biomedical Campus
    Photographs:


  • Author: Oliveira, Carla C.
    Title: Dr. Ana Casañal
    Reference The RNA Society 5 February 2019
    Year: 2019
    Type: Career Structure
    Subject: RNA Society member spotlight on Ana Casañal, postdoc in Lori Passmore’s group in the LMB’s Structural Studies Division, including Ana’s tips on overcoming research challenges and advice for junior researchers.
    Keywords: Ana Casañal; Lori Passmore; macromolecular machines; mRNA; cleavage and polyadenylation factor (CPF); cryo-EM structure; scientific career
    Photographs: Ana Casañal in lab


  • Author: Brackley, Paul
    Title: A ‘true great’: Nobel Laureate, pioneer and former LMB director Sydney Brenner dies at the age of 92
    Reference Cambridge Independent 10-16 April 2019
    Year: 2019
    Type: Obituary
    Subject: One of the “true greats” of biology, Nobel Laureate Sydney Brenner; has died at the age of 92.
    Keywords: Sydney Brenner; director; John Sulston; H. Robert Horvitz; Jan Löwe; nematode worm; C. elegans; Francis Crick; Genetic Division; Cell Biology; bacteriophage; virus; La Jolla; Leslie Barnett; Human Genome Project; RNA
    Photographs: Sydney in the 1960’s; Sydney and Francis Crick signing blackboard.


  • Author: Brackley, Paul
    Title: Unravelling protein structures found in the brains of dementia patients
    Reference Cambridge Independent 3-9 April 2019
    Year: 2019
    Type: Awards & Prizes
    Subject: Dr Benjamin Falcon has won a Rising Star Award from Alzheimer’s Research UK for his work, which could aid the diagnosis and eventually the treatment of diseases including Alzheimer’s and CTE
    Keywords: Ben Falcon; Alzheimer’s Research; tau proteins; Michel Goedert; Pick’s disease; chronic traumatic encephalopathy (CTE); neurodegenerative; cryo-EM; dementia; Rising Star Award; filaments; boxers American football player
    Photographs: Ben Falcon in front of 3D image of the structure of tau filaments in CTE


  • Author: Devlin, Hannah
    Title: Scientists grow ‘mini-brain on the move’ that can contract muscle
    Reference The Guardian 18 March 2019
    Year: 2019
    Type: Science
    Subject: Researchers in Madeline Lancaster’s group have developed a method of growing cerebral organoids, or mini-brains, that allows longer-term development and showed that these mini-brains can stimulate muscle contraction
    Keywords: Madeline Lancaster; miniature brain; spinal cord; brain organoid; human stem cell; mouse embryo; motor neurone disease; epilepsy; schizophrenia; muscle tissue
    Photographs:


  • Author: ALZFORUM
    Title: Traumatic Tau: Filaments from CTE Share Distinct Structure
    Reference ALZFORUM 21 March 2019
    Year: 2019
    Type: Science
    Subject: Researchers in Michel Goedert’s and Sjors Scheres’ groups have revealed the structure of tau filaments from the head injury-associated neurodegenerative disease chronic traumatic encephalopathy
    Keywords: Michel Goedert; Sjors Scheres; chronic traumatic encephalopathy (CTE); Tau filaments; Alzheimer’s disease; “punch-drunk syndrome”; neurodegenerative; Pick’s disease; cryo-EM; Benjamin Falcon; boxers; American Football player
    Photographs:


  • Author: Botelho, Alyssa
    Title: Life IN Brief - Sydney Brenner Microbiologist
    Reference The i reported from The Washington Post 15 April 2019
    Year: 2019
    Type: Obituary
    Subject: Obituary for Sydney Brenner that appeared in The Washington Post
    Keywords: Sydney Brenner; ‘The Science of Life’; Francis Crick; ; C. elegans; John Sulston; H Robert Horvitz; Human Genome Project
    Photographs: Sydney giving a lecture


  • Author: Carr, Cella
    Title: 2019 alumni awards
    Reference EMBL etc Alumni 21 February 219
    Year: 2019
    Type: Alumni
    Subject: Tanmay Bharat, a former post-doctoral researcher in Jan Löwe’s group, and previously a PhD student with John Briggs at EMBL, wins for his novel applications of electron cryo-tomography in visualising the molecular structures of bacterial biofilms
    Keywords: Tanmay Bharat; EMBL alumni; John Kendrew award; cryo-electron tomography; structural biology; cryo-EM; bacteria; John Briggs; Jan Löwe; Sjors Scheres; infection; biofilm
    Photographs: Tanmay Bharat, head shot


  • Author: The Francis Crick Institute
    Title: Introducing Rupert Beale, clinical researcher
    Reference The Francis Crick Institute 23 April 2019
    Year: 2019
    Type: Alumni
    Subject: Rupert Beale, a former PhD student with Michael Neuberger and post-doctoral researcher working with Felix Randow, is profiled as the first clinical early-career group leader at the Francis Crick Institute
    Keywords: Rupert Beale; Michael Neuberger; Felix Randow; virology; antibacterial; autophagy; bacteria; cell biology; Francis Crick Institute
    Photographs: Rupert Beale at The Crick


  • Author: Cambridge Institute for Medical Research (CIMR)
    Title: A new Director for the CIMR
    Reference CIMR 24 April 2019
    Year: 2019
    Type: Alumni
    Subject: Julian Rayner, a former PhD student in Hugh Pelham’s group in the LMB’s Cell Biology Division, will become the fourth Director of the Cambridge Institute of Medical Research
    Keywords: Julian Rayner; Cambridge Institute of Medical Research (CIMR); cell biology; Sanger Intitute; Plasmodium parasites; genomics
    Photographs: Julian Rayner in office


  • Author: Skehel, Mark
    Title: Working life: technology specialist Mark Skehel
    Reference MRC News 4 April 2019
    Year: 2019
    Type: Career Structure
    Subject: Hear career inspirations from Mark Skehel, Head of Mass Spectrometry & Proteomics at the LMB, in the latest ‘MRC talks’ podcast episode. Mark describes his career spanning industry and academia, and how he’s benefited from embracing change
    Keywords: Mark Skehel; mass spectrometry; John Walker; Edman sequencer; Proteomics; proteins
    Photographs: Mark Skehel in his lab


  • Author: MRC Life
    Title: Jason Chin awarded Sackler Prize
    Reference MRC Life April/May 2019
    Year: 2019
    Type: Awards & Prizes
    Subject: Jason Chin joint head of PNAC has been awarded the $100,000 Raymond and Beverly Sackler International Prize in the Physical Sciences
    Keywords: Jason Chin; award; Sackler Prize; advancing non-natural amino acid technology; biological discovery; $100,000
    Photographs: Jason Chin in lab (LMB photo)


  • Author: MRC Life
    Title: RNA Society/Scaringe Graduate Student Award for Max Wilkinson
    Reference MRC Life April/May 2019
    Year: 2019
    Type: Awards & Prizes
    Subject: Max Wilkinson a graduate student in Kiyoshi Nagai’s group is one of the winners of the RNA Society/Scaringe Graduate Student Awards
    Keywords: Max Wilkinson; RNA Society/Scaringe Graduate Student Awards; young investigators; spliceosome; Kiyoshi Nagai
    Photographs: Max Wilkinson in lab (LMB photo)


  • Author: Wilson, Michele
    Title: Your Body Clock Cares About When You Eat
    Reference Drug Discovery 25 April 2019
    Year: 2019
    Type: Science
    Subject: John O’Neill’s group have identified insulin as a primary signal that synchronises the body’s circadian rhythm in response to meal times
    Keywords: John O’Neill; circadian rhythm; jet lag; “grogginess”; fruit flies; insulin; mTOR signaling; PTEN
    Photographs:


  • Author: Devlin, Hannah
    Title: Alcohol can cause irreversible genetic damage to stem cells, says study
    Reference The Guardian 3 January 2018
    Year: 2018
    Type: Science
    Subject: Link between drinking and cancer clarified by study – led by KJ Patel’s group in the LMB’s PNAC Division – which indicates alcohol causes cancer by scrambling DNA in cells, eventually leading to mutations.
    Keywords: KJ Patel; alcohol; cancer; acetaldehyde; DNA damage; aldehyde dehydrogenase 2 (ALDH2); flushing mutation; stem cells; blood cells
    Photographs:


  • Author: Brackley, Paul
    Title: Magnetic attraction of AstraZeneca to MRC Laboratory of Molecular Biology
    Reference Cambridge Independent 8 January 2018
    Year: 2018
    Type: Biotechnology
    Subject: AstraZeneca has moved its Nuclear Magnetic Resonance laboratory to the LMB while its new global R&D centre is built nearby.
    Keywords: AstraZeneca; Maria Flocco; nuclear magnetic resonance (NMR); Hugh Pelham; David Neuhaus; Kevin Embrey; superconducting solenoid; Blue Skies; PAR; cancer; drug discovery; cryo-electron microscopy; consortium
    Photographs: David Neuhaus, and Kevin Embrey in the nuclear magnetic resonance (NMR) lab


  • Author: Davies, Emma
    Title: The rhythm of life
    Reference Education in Chemistry 11 January 2018
    Year: 2018
    Type: Science
    Subject: John O’Neill, from Cell Biology Division, discusses how unravelling the complex mechanisms of the body clock has led to some fascinating discoveries worthy of the 2017 Nobel Prize in Physiology or Medicine.
    Keywords: circadian rhythms; John O’Neill; Jeffrey Hall; Michael Rosbash; Michael Young; clock genes; PER; TIM protein; jet lag; suprachiasmatic nucleus (SCN)
    Photographs:


  • Author: Arney, Kat
    Title: Unlocking the secrets of the brain - From autism and schizophrenia to Alzheimer’s lab-grown mini-brains could be the key to solving the biggest mysteries about human development and disease
    Reference Science Focus 5 January 2018
    Year: 2018
    Type: Science
    Subject: Madeline Lancaster, from the LMB’s Cell Biology Division, discusses how lab-grown ‘mini-brains’ could be the key to solving the biggest mysteries about human brain development and disease.
    Keywords: Madeline Lancaster; ‘mini-brain’; organoids; brain stem cells; ‘rosettes’; ‘black box’; ‘brain Lego’; epilepsy; Alzheimer’s disease; telomeres; autism
    Photographs:


  • Author: International Society for Computational Biology (ISCB)
    Title: 2018 ISCB Innovator Award M. Madan Babu
    Reference ISCB 15 February 2018
    Year: 2018
    Type: Awards & Prizes
    Subject: The Award is given to a leading scientist who is within a decade and half of receiving their PhD degree, and has consistently made outstanding contributions to the field and continues to forge new directions.
    Keywords: Award; Madan Babu; ISCB innovator award; cellular regulation; signalling proteins;
    Photographs: Portrait of Madan


  • Author: Brackley, Paul
    Title: Dr Jan Löwe says he’s ‘humbled’ to take over as director of MRC Laboratory of Molecular Biology
    Reference Cambridge Independent 14 February 2018
    Year: 2018
    Type: Events and Celebrations
    Subject: Deputy Director, Jan Löwe, will be taking over from Hugh Pelham as Director of the LMB this spring
    Keywords: Jan Löwe; new director; Hugh Pelham; “excited and humbled”; ‘Nobel Prize factory’; Richard Henderson
    Photographs: Jan Löwe (LMB); Hugh Pelham (LMB); Building; Hugh Pelham with Richard Henderson; picture of crowds on an open day


  • Author: Knapton, Sarah
    Title: Alzheimer’s disease will become manageable like HIV, say award-winning scientists
    Reference The Telegraph 6 March 2018
    Year: 2018
    Type: Awards & Prizes
    Subject: 2018 Brain Prize winner Michel Goedert, group leader in the Neurobiology Division, who discovered the importance of tau protein in Alzheimer’s said he could see a time when dementia became a chronic illness like HIV.
    Keywords: Michel Goedert; Brain Prize; tau protein; Alzheimer’s; HIV; dementia; Lundbeck Foundation; amyloid; neurodegenerative disease; John Hardy; Bart De Strooper; Christian Haass
    Photographs:


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