{"id":2,"date":"2022-02-14T14:43:57","date_gmt":"2022-02-14T14:43:57","guid":{"rendered":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/?page_id=2"},"modified":"2026-01-16T12:14:34","modified_gmt":"2026-01-16T12:14:34","slug":"home","status":"publish","type":"page","link":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/","title":{"rendered":"Cellular patterns"},"content":{"rendered":"\n<p class=\"has-larger-font-size\"><\/p>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-wideleft\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"has-large-font-size\">The &#8220;cell&#8221; is the simplest living homeostatic unity with complex characteristics: identity, evolution, time, memory, communication, resilience. In general terms the cell can be thought as a simplified molecular ecosystem, where complex living behaviours arise from the interplay between organic and mechano-chemical elements, many of which comes from the environmental context.<\/p>\n\n\n\n<p class=\"has-larger-font-size\"><strong>The macromolecular basis of organelle shape and remodelling<\/strong><\/p>\n\n\n\n<p class=\"has-large-font-size\">Our lab searches for the ruling bio-physical and chemical principles which allow cellular life with a focus on the architecture of the nucleus, the main membrane compartment which transduce information. Broadly we aim to answer the following fundamental question: <\/p>\n\n\n\n<p class=\"has-large-font-size\">How does compartment shape, function and movement emerge from macromolecules organisation? <\/p>\n\n\n\n<p class=\"has-large-font-size\">We carry out both blue-sky and biomedicine research projects on the macromolecular basis of nuclear architecture and remodelling, and we develop new tools and algorithms to reach our goals and for a large community of scientists. <\/p>\n\n\n\n<p class=\"has-large-font-size\">We work as an interdisciplinary and collaborative team of scientists whose goal is to produce high-quality research outputs.<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"670\" height=\"642\" data-id=\"279\" src=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-content\/uploads\/sites\/33\/2022\/03\/image_Matteo_adv.png\" alt=\"\" class=\"wp-image-279\" srcset=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-content\/uploads\/sites\/33\/2022\/03\/image_Matteo_adv.png 670w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-content\/uploads\/sites\/33\/2022\/03\/image_Matteo_adv-300x287.png 300w\" sizes=\"auto, (max-width: 670px) 100vw, 670px\" \/><\/figure>\n<\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p><a href=\"https:\/\/bsky.app\/profile\/matteoall.bsky.social\">The Allegretti Lab&#8217;s Bluesky account<\/a><\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[],"class_list":{"0":"post-2","1":"page","2":"type-page","3":"status-publish","5":"entry"},"featured_image_src":null,"featured_image_src_square":null,"_links":{"self":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":49,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":925,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-json\/wp\/v2\/pages\/2\/revisions\/925"}],"wp:attachment":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-json\/wp\/v2\/media?parent=2"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/allegretti\/wp-json\/wp\/v2\/categories?post=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}