Giulia Paci

Giulia Paci

Postdoc

I am a biophysicist interested in understanding the interplay between mechanical forces and molecular processes across biological scales.

Throughout animal development, tissues with distinct morphologies and functions have to assume their specific 3D shape under the continuous influence of mechanical forces. These forces can be intrinsic to the tissue (generated locally by the cytoskeleton) or extrinsic and due to an interaction with neighbouring tissues or the environment. Decades of work on different model systems have elucidated the contribution of genetic programs and signalling to morphogenesis; however, the reverse process is not yet well understood.

Working jointly between the Baum and Mao labs, and using the Drosophila wing disc as a model system, I aim to reveal how developmental programs respond to and buffer mechanical stresses.

I’m also a passionate advocate for science outreach: the latest science communication programs I’ve participated in are “Letters to a Pre-Scientist” and the Wellcome/UKRI-funded “I’m a Scientist” online engagement activity.

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Publications:

1. Paci G, Mao Y (2021) Forced into shape: Mechanical forces in Drosophila development and homeostasis. Seminars in Cell & Developmental Biology.
2. Paci G, Zheng T, Caria J, Zilman A and Lemke EA (2021) Molecular determinants of large cargo transport into the nucleus. eLife, 9, e55963.
3. Celetti G*, Paci G*, Caria J, VanDelinder V, Bachand G, & Lemke EA (2020) The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes. The Journal of cell biology, 219(1).
4. Paci G*, Caria J*, Lemke EA (2020) Cargo transport through the nuclear pore complex at a glance. Journal of Cell Science, 134.2 (2021): jcs247874.
5. Paci G, Kornau L, Haas E, Marchetti D, Wang L, Prevedel R and Szmolenszky A (2021) Microscope in action: an interdisciplinary fluorescence microscopy hands-on resource for secondary schools (accepted at The Biophysicist).
6. Kozma E, Paci G, Girona, GE, Lemke, EA, & Kele P (2018) Fluorogenic Tetrazine-Siliconrhodamine Probe for the Labeling of Noncanonical Amino Acid Tagged Proteins. Noncanonical Amino Acids (pp. 337-363). Humana Press, New York, NY.
7. Kozma E, Girona GE, Paci G, Lemke EA, & Kele P (2017) Bioorthogonal double-fluorogenic siliconrhodamine probes for intracellular super- resolution microscopy. Chemical Communications, 53(50), 6696-6699. 
8. Paci G, Lemke EA. (2017) Shining a light on phase separation in the cell. Cell. 168.1-2 11-13.        
9. Nikić I, Girona, GE, Kang JH, Paci G, Mikhaleva S, Koehler C, Shymanska NV, Santos CV, Spitz D, & Lemke, EA (2016) Debugging Eukaryotic Genetic Code Expansion for