{"id":785,"date":"2023-12-05T15:22:01","date_gmt":"2023-12-05T15:22:01","guid":{"rendered":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/?p=785"},"modified":"2024-03-05T18:21:53","modified_gmt":"2024-03-05T18:21:53","slug":"archaeal-cell-biology","status":"publish","type":"post","link":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/archaeal-cell-biology\/","title":{"rendered":"Archaeal Cell Biology"},"content":{"rendered":"\n<p>Archaea are everywhere. While Archaea remain the most poorly understood domain of life on Earth, recent work has shown that Archaea share many aspects of their cell biology with Bacteria, as the result of common ancestry, and with eukaryotes &#8211; as a consequence of the emergence of eukaryotes from the merger of a bacterial cell with an archaeal cell around two billion years ago. At the same time, there are aspects of archaeal cell biology that are unique. Together, these facts make Archaea fascinating subjects for evolutionary cell biology. Our lab uses Archaea to explore an array of fundamental questions in cell biology, including: cell organisation, the archaeal membrane, the archaeal cell division cycle, and the dialogue between Archaea and their symbiotic partners.<\/p>\n\n\n\n<p>People Involved: <a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/alice-cezanne\/\" data-type=\"post\" data-id=\"293\">Alice Cezanne<\/a>, <a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/sherman-foo\/\" data-type=\"post\" data-id=\"805\">Sherman Foo<\/a>, <a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/iain-richard\/\">Iain Richard<\/a>,<a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/joe-parham\/\"> Joe Parham<\/a><\/p>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/pexels-kerry-534371-1024x683.jpg\" alt=\"\" class=\"wp-image-1099 size-full\" srcset=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/pexels-kerry-534371-1024x683.jpg 1024w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/pexels-kerry-534371-300x200.jpg 300w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/pexels-kerry-534371-768x512.jpg 768w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/pexels-kerry-534371-1536x1024.jpg 1536w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/pexels-kerry-534371-2048x1365.jpg 2048w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/pexels-kerry-534371-600x400.jpg 600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-text-align-center has-large-font-size\">We study the cell biology of organisms from a wide array of extreme environments. From sulphur springs in Yellowstone National Park, to anaerobic microbial matts in the oceans off the coast of Australia.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-cover alignfull has-parallax is-repeated\" style=\"min-height:97px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-70 has-background-dim\"><\/span><div role=\"img\" class=\"wp-block-cover__image-background wp-image-1225 has-parallax is-repeated\" style=\"background-position:73% 23%;background-image:url(https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/website-new-cells.png)\"><\/div><div class=\"wp-block-cover__inner-container is-layout-constrained wp-block-cover-is-layout-constrained\">\n<p class=\"has-text-align-center has-large-font-size\"><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile\" style=\"grid-template-columns:auto 39%\"><div class=\"wp-block-media-text__content\">\n<p class=\"has-text-align-center has-large-font-size\">Imaging Hell:&nbsp;after many years of effort, we are now able to image&nbsp;<em>Sulfolobus<\/em>&nbsp;cells as they grow and divide under the microscope at 75\u00b0C.&nbsp;<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><a href=\"https:\/\/www.frontiersin.org\/journals\/microbiology\/articles\/10.3389\/fmicb.2023.1233032\/full\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"176\" height=\"176\" src=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/website-cell-gif.gif\" alt=\"\" class=\"wp-image-1087 size-full\" \/><\/a><\/figure><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:500px\">\n<p class=\"has-text-align-right\" style=\"font-size:14px\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-cover alignfull has-parallax is-repeated\" style=\"min-height:97px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-70 has-background-dim\"><\/span><div role=\"img\" class=\"wp-block-cover__image-background wp-image-1225 has-parallax is-repeated\" style=\"background-position:58% 77%;background-image:url(https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/website-new-cells.png)\"><\/div><div class=\"wp-block-cover__inner-container is-layout-constrained wp-block-cover-is-layout-constrained\">\n<p class=\"has-text-align-center has-large-font-size\"><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:44% auto\"><figure class=\"wp-block-media-text__media\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0960982220306606?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"377\" height=\"377\" src=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/website-sulfoscope.png\" alt=\"\" class=\"wp-image-1308 size-full\" srcset=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/website-sulfoscope.png 377w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/website-sulfoscope-300x300.png 300w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/website-sulfoscope-150x150.png 150w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/website-sulfoscope-75x75.png 75w\" sizes=\"auto, (max-width: 377px) 100vw, 377px\" \/><\/a><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-text-align-center has-large-font-size\">We have designed a heating apparatus called the Sulfoscope that allows us to maintain cells at high temperatures while imaging.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:40%\">\n<p style=\"font-size:14px\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-cover alignfull has-parallax is-repeated\" style=\"min-height:97px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-70 has-background-dim\"><\/span><div role=\"img\" class=\"wp-block-cover__image-background wp-image-1225 has-parallax is-repeated\" style=\"background-position:8% 77%;background-image:url(https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/website-new-cells.png)\"><\/div><div class=\"wp-block-cover__inner-container is-layout-constrained wp-block-cover-is-layout-constrained\">\n<p class=\"has-text-align-center has-large-font-size\"><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<p class=\"has-text-align-center has-large-font-size\">Through high-resolution microscopy and molecular genetics, we are able to capture stunning images that reveal the dynamics of archaeal cell organisation.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-1.png\" alt=\"\" class=\"wp-image-765 size-full\" srcset=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-1.png 600w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-1-300x300.png 300w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-1-150x150.png 150w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-1-75x75.png 75w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure><\/div>\n\n\n\n<div style=\"color:#ddd\" class=\"wp-block-genesis-blocks-gb-spacer gb-block-spacer gb-divider-solid gb-spacer-divider gb-divider-size-5\"><hr style=\"height:231px\" \/><\/div>\n\n\n<section class=\"gb-block-post-grid featuredpost aligncenter\"><div class=\"gb-post-grid-items is-grid columns-3\"><article id=\"post-215\" class=\"gb-post-grid-item post-215 post type-post status-publish format-standard has-post-thumbnail category-what-we-do entry\"><div class=\"gb-block-post-grid-image\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/origin-of-eukaryotes\/\" rel=\"bookmark\" aria-hidden=\"true\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2022\/11\/ASGARD-FISH-nonspec-2.png\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2022\/11\/ASGARD-FISH-nonspec-2.png 600w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2022\/11\/ASGARD-FISH-nonspec-2-300x300.png 300w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2022\/11\/ASGARD-FISH-nonspec-2-150x150.png 150w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2022\/11\/ASGARD-FISH-nonspec-2-75x75.png 75w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/div><div class=\"gb-block-post-grid-text\"><header class=\"gb-block-post-grid-header\"><h3 class=\"gb-block-post-grid-title\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/origin-of-eukaryotes\/\" rel=\"bookmark\">Asgard Archaea and the Origin of Eukaryotes<\/a><\/h3><div class=\"gb-block-post-grid-byline\"><\/div><\/header><div class=\"gb-block-post-grid-excerpt\"><p>Asgard Archaea were recently identified as the closest living relatives of modern-day eukaryotes. Remarkably, the genomes of Asgard Archaea encode&hellip;<\/p>\n<p><a class=\"gb-block-post-grid-more-link gb-text-link\" href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/origin-of-eukaryotes\/\" rel=\"bookmark\">Find Out More <span class=\"screen-reader-text\">Asgard Archaea and the Origin of Eukaryotes<\/span><\/a><\/p><\/div><\/div><\/article>\n<article id=\"post-213\" class=\"gb-post-grid-item post-213 post type-post status-publish format-standard has-post-thumbnail category-what-we-do entry\"><div class=\"gb-block-post-grid-image\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/cell-division\/\" rel=\"bookmark\" aria-hidden=\"true\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" width=\"837\" height=\"837\" src=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-5.png\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-5.png 837w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-5-300x300.png 300w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-5-150x150.png 150w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-5-768x768.png 768w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-5-75x75.png 75w, https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2023\/12\/Picture-5-600x600.png 600w\" sizes=\"auto, (max-width: 837px) 100vw, 837px\" \/><\/a><\/div><div class=\"gb-block-post-grid-text\"><header class=\"gb-block-post-grid-header\"><h3 class=\"gb-block-post-grid-title\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/cell-division\/\" rel=\"bookmark\">Cell Division in Archaea<\/a><\/h3><div class=\"gb-block-post-grid-byline\"><\/div><\/header><div class=\"gb-block-post-grid-excerpt\"><p>Cell division is the process by which one cell becomes two. It is the most complex event in the life&hellip;<\/p>\n<p><a class=\"gb-block-post-grid-more-link gb-text-link\" href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/cell-division\/\" rel=\"bookmark\">Find Out More <span class=\"screen-reader-text\">Cell Division in Archaea<\/span><\/a><\/p><\/div><\/div><\/article>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>Archaea are everywhere. While Archaea remain the most poorly understood domain of life on Earth, recent work has shown that Archaea share many aspects of their cell biology with Bacteria, as the result of common ancestry, and with eukaryotes &#8211; as a consequence of the emergence of eukaryotes from the merger of a bacterial cell [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":989,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[7],"tags":[],"class_list":{"0":"post-785","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-what-we-do","8":"entry"},"featured_image_src":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/Screenshot-2024-02-14-at-13.02.05-600x400.png","featured_image_src_square":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-content\/uploads\/sites\/36\/2024\/02\/Screenshot-2024-02-14-at-13.02.05-600x600.png","author_info":{"display_name":"","author_link":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/author\/"},"_links":{"self":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/posts\/785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/comments?post=785"}],"version-history":[{"count":49,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/posts\/785\/revisions"}],"predecessor-version":[{"id":1677,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/posts\/785\/revisions\/1677"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/media\/989"}],"wp:attachment":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/media?parent=785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/categories?post=785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/baum\/wp-json\/wp\/v2\/tags?post=785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}