Selected publications
(for Full publication list click here)
- Mali, G.R., Ali, F.A., Lau, C.K., Begum, F., Boulanger, J., Howe, J.D., Chen, Z.A., Rappsilber, J., Skehel, M., Carter, A.P. (2021)
Shulin packages axonemal outer dynein arms for ciliary targeting.
Science 371(6532): 910-916 - Urnavicius, L., Lau, C.K., Elshenawy, M.M., Morales-Rios, E., Motz, C., Yildiz, A., Carter, A.P. (2018)
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Nature 554(7691): 202-206 - Zhang, K., Foster, H.E., Rondelet, A., Lacey, S.E., Bahi-Buisson, N., Bird, A.W., Carter, A.P. (2017)
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
Cell 169(7): 1303-1314.e18 - Urnavicius, L., Zhang, K., Diamant, A.G., Motz, C., Schlager, M.A., Yu, M., Patel, N.A., Robinson, C.V., Carter, A.P. (2015)
The structure of the dynactin complex and its interaction with dynein.
Science 347(6229): 1441-1446 - Schmidt, H., Zalyte, R., Urnavicius, L., Carter, A.P. (2015)
Structure of human cytoplasmic dynein-2 primed for its power stroke.
Nature 518(7539): 435-438 - Schlager, M.A., Hoang, H.T., Urnavicius, L., Bullock, S.L., Carter, A.P. (2014)
In vitro reconstitution of a highly processive recombinant human dynein complex.
EMBO J 33(17): 1855-68
Full publications
(for selected publications click here)
2024
- Salvador-Garcia, D., Jin, L., Hensley, A., Gölcük, M., Gallaud, E., Chaaban, S., Port, F., Vagnoni, A., Planelles-Herrero, V.J., McClintock, M.A., Derivery, E., Carter, A.P., Giet, R., Gür, M., Yildiz, A., Bullock, S.L. (2024)
A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression.
J Cell Biol 223(10) - Slivka, J., Gleave, E., Wijewardena, D.P., Canty, J.T., Selvin, P.R., Carter, A.P., Yildiz, A. (2024)
Stepping dynamics of dynein characterized by MINFLUX.
bioRxiv [Epub ahead of print] - Fellows, A.D., Bruntraeger, M., Burgold, T., Bassett, A.R., Carter, A.P. (2024)
Dynein and dynactin move long-range but are delivered separately to the axon tip.
J Cell Biol 223(5) - Singh, K., Lau, C.K., Manigrasso, G., Gama, J.B., Gassmann, R., Carter, A.P. (2024)
Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science 383(6690): eadk8544
2023
- Ventura Santos, C., Rogers, S.L., Carter, A.P. (2023)
CryoET shows cofilactin filaments inside the microtubule lumen.
EMBO Rep 24(11): e57264 - Salvador-Garcia, D., Jin, L., Hensley, A., Gölcük, M., Gallaud, E., Chaaban, S., Port, F., Vagnoni, A., Planelles-Herrero, V.J., McClintock, M.A., Derivery, E., Carter, A.P., Giet, R., Gür, M., Yildiz, A., Bullock, S.L. (2023)
A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression.
bioRxiv [Epub ahead of print] - Santos, C.V., Rogers, S.L., Carter, A.P. (2023)
CryoET shows cofilactin filaments inside the microtubule lumen.
bioRxiv [Epub ahead of print]
2022
- d'Amico, E.A., Ud Din Ahmad, M., Cmentowski, V., Girbig, M., Müller, F., Wohlgemuth, S., Brockmeyer, A., Maffini, S., Janning, P., Vetter, I.R., Carter, A.P., Perrakis, A., Musacchio, A. (2022)
Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.
J Cell Biol 221(11) - Chaaban, S., Carter, A.P. (2022)
Publisher Correction: Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature 611(7935): E8 - He, P., Liu, B., Gao, X., Yan, Q., Pei, R., Sun, J., Chen, Q., Hou, R., Li, Z., Zhang, Y., Zhao, J., Sun, H., Feng, B., Wang, Q., Yi, H., Hu, P., Li, P., Zhang, Y., Chen, Z., Niu, X., Zhong, X., Jin, L., Liu, X., Qu, K., Ciazynska, K.A., Carter, A.P., Briggs, J.A.G., Chen, J., Liu, J., Chen, X., He, J., Chen, L., Xiong, X. (2022)
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope.
Nat Microbiol 7(10): 1635-1649 - Chaaban, S., Carter, A.P. (2022)
Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature 610(7930): 212-216 - Qu, K., Chen, Q., Ciazynska, K.A., Liu, B., Zhang, X., Wang, J., He, Y., Guan, J., He, J., Liu, T., Zhang, X., Carter, A.P., Xiong, X., Briggs, J.A.G. (2022)
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike.
PLoS Pathog 18(7): e1010583 - Fermie, J., de Jager, L., Foster, H.E., Veenendaal, T., de Heus, C., van Dijk, S., Ten Brink, C., Oorschot, V., Yang, L., Li, W., Müller, W.H., Howes, S., Carter, A.P., Förster, F., Posthuma, G., Gerritsen, H.C., Klumperman, J., Liv, N. (2022)
Bimodal endocytic probe for three-dimensional correlative light and electron microscopy.
Cell Rep Methods 2(5): 100220 - Foster, H.E., Ventura Santos, C., Carter, A.P. (2022)
A cryo-ET survey of microtubules and intracellular compartments in mammalian axons.
J Cell Biol 221(2)
2021
- Lau, C.K., O'Reilly, F.J., Santhanam, B., Lacey, S.E., Rappsilber, J., Carter, A.P. (2021)
Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.
EMBO J 40(8): e106164 - Mali, G.R., Ali, F.A., Lau, C.K., Begum, F., Boulanger, J., Howe, J.D., Chen, Z.A., Rappsilber, J., Skehel, M., Carter, A.P. (2021)
Shulin packages axonemal outer dynein arms for ciliary targeting.
Science 371(6532): 910-916 - Fokin, A.I., David, V., Oguievetskaia, K., Derivery, E., Stone, C.E., Cao, L., Rocques, N., Molinie, N., Henriot, V., Aumont-Nicaise, M., Hinckelmann, M.V., Saudou, F., Le Clainche, C., Carter, A.P., Romet-Lemonne, G., Gautreau, A.M. (2021)
The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex.
Sci Adv 7(3)
2020
- Pellegrini, L., Albecka, A., Mallery, D.L., Kellner, M.J., Paul, D., Carter, A.P., James, L.C., Lancaster, M.A. (2020)
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids.
Cell Stem Cell 27(6): 951-961.e5 - Xiong, X., Qu, K., Ciazynska, K.A., Hosmillo, M., Carter, A.P., Ebrahimi, S., Ke, Z., Scheres, S.H.W., Bergamaschi, L., Grice, G.L., Zhang, Y., , ., Nathan, J.A., Baker, S., James, L.C., Baxendale, H.E., Goodfellow, I., Doffinger, R., Briggs, J.A.G. (2020)
A thermostable, closed SARS-CoV-2 spike protein trimer.
Nat Struct Mol Biol 27(10): 934-941 - Vincent, J., Preston, M., Mouchet, E., Laugier, N., Corrigan, A., Boulanger, J., Brown, D.G., Clark, R., Wigglesworth, M., Carter, A.P., Bullock, S.L. (2020)
A High-Throughput Cellular Screening Assay for Small-Molecule Inhibitors and Activators of Cytoplasmic Dynein-1-Based Cargo Transport.
SLAS Discov 25(9): 985-999
2019
- Toropova, K., Zalyte, R., Mukhopadhyay, A.G., Mladenov, M., Carter, A.P., Roberts, A.J. (2019)
Structure of the dynein-2 complex and its assembly with intraflagellar transport trains.
Nat Struct Mol Biol 26(9): 823-829 - Lacey, S.E., He, S., Scheres, S.H., Carter, A.P. (2019)
Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule.
Elife 8 - Can, S., Lacey, S., Gur, M., Carter, A.P., Yildiz, A. (2019)
Directionality of dynein is controlled by the angle and length of its stalk.
Nature 566(7744): 407-410
2018
- Reck-Peterson, S.L., Redwine, W.B., Vale, R.D., Carter, A.P. (2018)
Publisher Correction: The cytoplasmic dynein transport machinery and its many cargoes.
Nat Rev Mol Cell Biol 19(7): 479 - Reck-Peterson, S.L., Redwine, W.B., Vale, R.D., Carter, A.P. (2018)
The cytoplasmic dynein transport machinery and its many cargoes.
Nat Rev Mol Cell Biol 19(6): 382-398 - Urnavicius, L., Lau, C.K., Elshenawy, M.M., Morales-Rios, E., Motz, C., Yildiz, A., Carter, A.P. (2018)
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Nature 554(7691): 202-206
2017
- Nieuwburg, R., Nashchekin, D., Jakobs, M., Carter, A.P., Khuc Trong, P., Goldstein, R.E., St Johnston, D. (2017)
Localised dynactin protects growing microtubules to deliver mRNA to the posterior cortex of the oocyte.
Elife 6 - Zhang, K., Foster, H.E., Rondelet, A., Lacey, S.E., Bahi-Buisson, N., Bird, A.W., Carter, A.P. (2017)
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
Cell 169(7): 1303-1314.e18 - Steinman, J.B., Santarossa, C.C., Miller, R.M., Yu, L.S., Serpinskaya, A.S., Furukawa, H., Morimoto, S., Tanaka, Y., Nishitani, M., Asano, M., Zalyte, R., Ondrus, A.E., Johnson, A.G., Ye, F., Nachury, M.V., Fukase, Y., Aso, K., Foley, M.A., Gelfand, V.I., Chen, J.K., Carter, A.P., Kapoor, T.M. (2017)
Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.
Elife 6 - Hoang, H.T., Schlager, M.A., Carter, A.P., Bullock, S.L. (2017)
DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein-dynactin-cargo adaptor complexes.
Proc Natl Acad Sci U S A 114(9): E1597-E1606
2016
- Belyy, V., Schlager, M.A., Foster, H., Reimer, A.E., Carter, A.P., Yildiz, A. (2016)
The mammalian dynein-dynactin complex is a strong opponent to kinesin in a tug-of-war competition.
Nat Cell Biol 18(9): 1018-24 - Schmidt, H., Carter, A.P. (2016)
Review: Structure and mechanism of the dynein motor ATPase.
Biopolymers 105(8): 557-67 - Carter, A.P., Diamant, A.G., Urnavicius, L. (2016)
How dynein and dynactin transport cargos: a structural perspective.
Curr Opin Struct Biol 37: 62-70 - See, S.K., Hoogendoorn, S., Chung, A.H., Ye, F., Steinman, J.B., Sakata-Kato, T., Miller, R.M., Cupido, T., Zalyte, R., Carter, A.P., Nachury, M.V., Kapoor, T.M., Chen, J.K. (2016)
Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity.
ACS Chem Biol 11(1): 53-60
2015
- Urnavicius, L., Zhang, K., Diamant, A.G., Motz, C., Schlager, M.A., Yu, M., Patel, N.A., Robinson, C.V., Carter, A.P. (2015)
The structure of the dynactin complex and its interaction with dynein.
Science 347(6229): 1441-1446 - Schmidt, H., Zalyte, R., Urnavicius, L., Carter, A.P. (2015)
Structure of human cytoplasmic dynein-2 primed for its power stroke.
Nature 518(7539): 435-438
2014
- Schlager, M.A., Hoang, H.T., Urnavicius, L., Bullock, S.L., Carter, A.P. (2014)
In vitro reconstitution of a highly processive recombinant human dynein complex.
EMBO J 33(17): 1855-68 - Gleave, E.S., Schmidt, H., Carter, A.P. (2014)
A structural analysis of the AAA+ domains in Saccharomyces cerevisiae cytoplasmic dynein.
J Struct Biol 186(3): 367-75
2013
- Carter, A.P. (2013)
Crystal clear insights into how the dynein motor moves.
J Cell Sci 126(Pt 3): 705-13
2012
- Schmidt, H., Gleave, E.S., Carter, A.P. (2012)
Insights into dynein motor domain function from a 3.3-Å crystal structure.
Nat Struct Mol Biol 19(5): 492-7, S1
2011
- Carter, A.P., Cho, C., Jin, L., Vale, R.D. (2011)
Crystal structure of the dynein motor domain.
Science 331(6021): 1159-65
2010
- Carter, A.P., Vale, R.D. (2010)
Communication between the AAA+ ring and microtubule-binding domain of dynein.
Biochem Cell Biol 88(1): 15-21
2009
- Houdusse, A., Carter, A.P. (2009)
Dynein swings into action.
Cell 136(3): 395-6
2008
- Carter, A.P., Garbarino, J.E., Wilson-Kubalek, E.M., Shipley, W.E., Cho, C., Milligan, R.A., Vale, R.D., Gibbons, I.R. (2008)
Structure and functional role of dynein's microtubule-binding domain.
Science 322(5908): 1691-5
2007
- Gennerich, A., Carter, A.P., Reck-Peterson, S.L., Vale, R.D. (2007)
Force-induced bidirectional stepping of cytoplasmic dynein.
Cell 131(5): 952-65
2006
- Reck-Peterson, S.L., Yildiz, A., Carter, A.P., Gennerich, A., Zhang, N., Vale, R.D. (2006)
Single-molecule analysis of dynein processivity and stepping behavior.
Cell 126(2): 335-48
2005
- Gibbons, I.R., Garbarino, J.E., Tan, C.E., Reck-Peterson, S.L., Vale, R.D., Carter, A.P. (2005)
The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk.
J Biol Chem 280(25): 23960-5
2003
- Brodersen, D.E., Clemons, W.M., Carter, A.P., Wimberly, B.T., Ramakrishnan, V. (2003)
Phasing the 30S ribosomal subunit structure.
Acta Crystallogr D Biol Crystallogr 59(Pt 11): 2044-50 - Ogle, J.M., Carter, A.P., Ramakrishnan, V. (2003)
Insights into the decoding mechanism from recent ribosome structures.
Trends Biochem Sci 28(5): 259-66
2002
- Ouwens, D.M., de Ruiter, N.D., van der Zon, G.C., Carter, A.P., Schouten, J., van der Burgt, C., Kooistra, K., Bos, J.L., Maassen, J.A., van Dam, H. (2002)
Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
EMBO J 21(14): 3782-93 - Brodersen, D.E., Clemons, W.M., Carter, A.P., Wimberly, B.T., Ramakrishnan, V. (2002)
Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA.
J Mol Biol 316(3): 725-68
2001
- Clemons, W.M., Brodersen, D.E., McCutcheon, J.P., May, J.L., Carter, A.P., Morgan-Warren, R.J., Wimberly, B.T., Ramakrishnan, V. (2001)
Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: purification, crystallization and structure determination.
J Mol Biol 310(4): 827-43 - Ogle, J.M., Brodersen, D.E., Clemons, W.M., Tarry, M.J., Carter, A.P., Ramakrishnan, V. (2001)
Recognition of cognate transfer RNA by the 30S ribosomal subunit.
Science 292(5518): 897-902 - Carter, A.P., Clemons, W.M., Brodersen, D.E., Morgan-Warren, R.J., Hartsch, T., Wimberly, B.T., Ramakrishnan, V. (2001)
Crystal structure of an initiation factor bound to the 30S ribosomal subunit.
Science 291(5503): 498-501 - Brodersen, D.E., Carter, A.P., Clemons, W.M., Morgan-Warren, R.J., Murphy, F.V., Ogle, J.M., Tarry, M.J., Wimberly, B.T., Ramakrishnan, V. (2001)
Atomic structures of the 30S subunit and its complexes with ligands and antibiotics.
Cold Spring Harb Symp Quant Biol 66: 17-32
2000
- Brodersen, D.E., Clemons, W.M., Carter, A.P., Morgan-Warren, R.J., Wimberly, B.T., Ramakrishnan, V. (2000)
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Cell 103(7): 1143-54 - Wimberly, B.T., Brodersen, D.E., Clemons, W.M., Morgan-Warren, R.J., Carter, A.P., Vonrhein, C., Hartsch, T., Ramakrishnan, V. (2000)
Structure of the 30S ribosomal subunit.
Nature 407(6802): 327-39 - Carter, A.P., Clemons, W.M., Brodersen, D.E., Morgan-Warren, R.J., Wimberly, B.T., Ramakrishnan, V. (2000)
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics.
Nature 407(6802): 340-8