{"id":5,"date":"2015-11-11T16:39:38","date_gmt":"2015-11-11T16:39:38","guid":{"rendered":"http:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hedge\/?page_id=5"},"modified":"2026-03-07T11:41:53","modified_gmt":"2026-03-07T11:41:53","slug":"research-topics","status":"publish","type":"page","link":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hegde\/research-topics\/","title":{"rendered":"Research Topics"},"content":{"rendered":"<ul>\n<li style=\"text-align: left\"><strong>Membrane protein biosynthesis<\/strong><\/li>\n<li style=\"text-align: left\"><strong>Cytosolic quality control<\/strong><\/li>\n<li style=\"text-align: left\"><strong>Quality control at the ribosome<\/strong><\/li>\n<li style=\"text-align: left\"><strong>Diseases of protein misfolding<\/strong><\/li>\n<\/ul>\n<p style=\"text-align: left\">To learn more, watch Manu&#8217;s <a href=\"https:\/\/www.ibiology.org\/cell-biology\/protein-localization-inside-cells\/\" target=\"_blank\" rel=\"noopener noreferrer\">iBiology talks<\/a>.<\/p>\n<p>Summary articles of recent key papers:<\/p>\n<ul>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/discovery-of-a-factor-that-accelerates-protein-deliveries-to-the-endoplasmic-reticulum\/\" target=\"_blank\" rel=\"noopener\">Discovery of a factor that accelerates protein deliveries to the ER<\/a> (2024)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/keeping-protein-subunits-in-check-via-assembly-quality-control\/\" target=\"_blank\" rel=\"noopener\">Keeping protein subunits in check via assembly quality control<\/a> (2023)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/pathway-for-making-multipass-membrane-proteins-elucidated\/\" target=\"_blank\" rel=\"noopener\">Pathway for making multipass membrane proteins elucidated<\/a> (2022)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/pathway-behind-disposal-of-orphan-proteins-identified\/\" target=\"_blank\" rel=\"noopener\">Pathway behind disposal of &#8216;orphan&#8217; proteins identified<\/a> (2021)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/discovery-of-a-chaperone-for-membrane-proteins\/\" target=\"_blank\" rel=\"noopener noreferrer\">Discovery of a new type of chaperone for membrane proteins<\/a> (2020)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/how-cells-avoid-and-resolve-ribosome-traffic-jams\/\" target=\"_blank\" rel=\"noopener noreferrer\">How cells avoid and resolve ribosome traffic jams<\/a> (2020)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/new-understanding-of-protein-abundance-control\/\" target=\"_blank\" rel=\"noopener noreferrer\">Discovery of a factor involved in tubulin autoregulation<\/a> (2019)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/new-insight-into-how-membrane-proteins-are-made\/\" target=\"_blank\" rel=\"noopener noreferrer\">Key role for EMC during GPCR biogenesis<\/a> (2018)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/discovery-of-a-sensor-for-ribosome-collisions\/\" target=\"_blank\" rel=\"noopener noreferrer\">Discovery of ZNF598 as a sensor of ribosome collisions<\/a> (2018)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/new-machinery-membrane-protein-insertion\/\" target=\"_blank\" rel=\"noopener noreferrer\">Discovery of EMC as a membrane protein insertase<\/a> (2017)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/mechanism-cleaning-leftover-proteins\/\" target=\"_blank\" rel=\"noopener noreferrer\">Discovery of UBE2O as a new quality control factor<\/a> (2017)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/uncovering-molecular-basis-triage-protein-synthesis\/\" target=\"_blank\" rel=\"noopener noreferrer\">Mechanism of nascent protein triage<\/a> (2017)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/an-open-translocation-channel-revealed\/\" target=\"_blank\" rel=\"noopener noreferrer\">Signal sequence recognition by the Sec translocon<\/a> (2016)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/protein-quality-control-system-mislocalised-proteins\/\" target=\"_blank\" rel=\"noopener noreferrer\">Discovery of Ubiquilins as a family of quality control factors<\/a> (2016)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/stop-codons-a-decoding-puzzle-decoded\/\" target=\"_blank\" rel=\"noopener noreferrer\">Structural basis of eukaryotic stop codon recognition<\/a> (2015)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/unfinished-proteins-find-needle-haystack\/\" target=\"_blank\" rel=\"noopener noreferrer\">Structural basis of nascent chain ubiquitination by RQC<\/a> (2015)<\/li>\n<li><a href=\"https:\/\/mrclmb.ac.uk\/news-events\/articles\/cryo-em-reveals-mammalian-protein-export-machinery\/\" target=\"_blank\" rel=\"noopener noreferrer\">Atomic resolution structure of a native ribosome-Sec61 complex<\/a> (2014)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Membrane protein biosynthesis Cytosolic quality control Quality control at the ribosome Diseases of protein misfolding To learn more, watch Manu&#8217;s iBiology talks. Summary articles of recent key papers: Discovery of a factor that accelerates protein deliveries to the ER (2024) Keeping protein subunits in check via assembly quality control (2023) Pathway for making multipass membrane [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"class_list":{"0":"post-5","1":"page","2":"type-page","3":"status-publish","5":"entry"},"_links":{"self":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hegde\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hegde\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hegde\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hegde\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hegde\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":23,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hegde\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":563,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hegde\/wp-json\/wp\/v2\/pages\/5\/revisions\/563"}],"wp:attachment":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/hegde\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}