Structures of some endocytic and
membrane trafficking proteins
--more coming soon!

Review on protein structures (.pdf)

FCHo2 F-BAR domain

William Mike Henne, Helen M. Kent, Marijn G.J. Ford, Balachandra G. Hegde, Oliver Daumke, P. Jonathan G. Butler, Rohit Mittal, Ralf Langen, Philip R. Evans, and Harvey T. McMahon (2007) Structure and Analysis of FCHo2 F-BAR Domain: a Dimerising and Membrane Recruitment Module that Effects Membrane Curvature. Structure (2007). Online version May2005: doi:10.1016/j.str.2007.05.002, Print version July2005.

Endophilin BAR domain

Gallop, J.L., Jao, C.C., Kent, H.M., Butler, P.J.G., Evans, P.R., Langen, R. and McMahon, H.T. (2006) Mechanism of endophilin N-BAR domain-mediated membrane curvature. EMBO J. 25, 2898-2910.

Drosophila Amphiphysin BAR domain

Peter, B.J., Kent, H.M., Mills, I.G., Vallis, Y., Butler, P.J.G., Evans, P.R. and McMahon, H.T. (2003) online on Science Express Nov 26; print version Jan 23, 2004

Epsin1 ENTH domain

ENTH alone ENTH bound to IP3

Structure in absence of lipid, left: Hyman J, Chen H, Di Fiore PP, De Camilli P, Brunger AT. (2000) J Cell Biol.149:537-46

Structure in presence of IP3 headgroup, right: Ford, M.G.J., Mills, I.G., Peter, B.J., Vallis, Y., Praefcke, G.J.K., Evans, P.R. and McMahon, H.T. (2002) Nature 419: 361-366.

AP180/CALM ANTH domain

Ford, M.G.J., Pearse, B., Higgins, M., Vallis, Y., Owen, D., Gibson, A., Hopkins, C.R., Evans, P.R. and McMahon, H.T. (2001) Science. 291, 1051-1055

Amphiphysin 2 SH3 domain

Owen DJ, Wigge P, Vallis Y, Moore JD, Evans PR, McMahon HT. (1998) EMBO J. 17: 5273-85

Eps15 EH2 domain

EH domain from Eps15

de Beer T, Hoofnagle AN, Enmon JL, Bowers RC, Yamabhai M, Kay BK, Overduin M. (1998) Science 281: 1357-60

Clathrin N-terminal domain

ter Haar E, Musacchio A, Harrison SC, Kirchhausen T. (1998), Cell 95:563-73

AP2 complex

AP2 complex mu + alpha and beta ears

Owen & Evans (1998) Science 282: 1327-32; Owen et al. (1999) Cell 97: 805-15; Owen et al. (2000) EMBO J. 19: 4216-27

Dynamin PH domain

EH domain from Eps15

Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. (1994) Cell 79:199-209;

Timm D, Salim K, Gout I, Guruprasad L, Waterfield M, Blundell T. Nat Struct Biol. (1994) 1:782-8

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