{"id":24,"date":"2023-11-21T12:07:05","date_gmt":"2023-11-21T12:07:05","guid":{"rendered":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/munro\/?page_id=24"},"modified":"2024-05-15T11:46:01","modified_gmt":"2024-05-15T10:46:01","slug":"gallery","status":"publish","type":"page","link":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/munro\/gallery\/","title":{"rendered":"Into The Unknome"},"content":{"rendered":"
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Dive into the depths of genome discovery.<\/p>\n\n\n\n

The Unknome (unknown genome) is a paper and online database written and manufactured for 10 tireless years by Sean Munro and his diligent team. Here you will discover everything about the Unknome from past to present projects, contacts to links and much more.<\/p>\n\n\n\n

Want to check out the Paper and Database for yourself?<\/h2>\n\n\n\n

If so these links will help you out! ><\/p>\n\n\n\n

The Unknome Database: https:\/\/unknome.mrc-lmb.cam.ac.uk\/<\/a><\/p>\n\n\n\n

The link to the paper: https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.3002222<\/a><\/p>\n\n\n\n

Unknome Wired Magazine Article : https:\/\/www.wired.co.uk\/article\/unknome-proteins-human-genome<\/a><\/p>\n\n\n\n

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What was the motivation to start?\u200b<\/h2>\n\n\n\n

For many years genome research has been neglected or, at least, not given near to enough attention into a subset of proteins. So Sean Munro, and Matthew Freeman lead the way into delving into the depths of experimenting writing and editing.<\/p>\n\n\n\n

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10 Years of Research Conducted<\/h4>\n\n\n\n

Spent Writing, Fine Tuning, And Editing.<\/p>\n\n\n\n

9 People<\/h4>\n\n\n\n

and their Hard Work And Effort.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

What Is a Genome?<\/h1>\n\n\n\n

Well if you were to consult Google or Wikipedia you would find something along the lines of, \u201cIn the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA.<\/p>\n\n\n\n

However, when looking into the unknome we delve into the “Mystery genes that keep us alive”, these fascinating genes have been neglected in prior genome research. In the words of Sean Munro \u201cA Genome is the complete set of genes that encodes the 20,000 different proteins that make up the human body, but for several thousands of these the functions have yet to come into our understanding, and these are the unknome.”<\/p>\n\n\n\n

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Upcoming Genome Projects<\/p>\n\n\n\n

+ Upcoming Partnerships & A More In depth View Of The Unknome<\/p>\n<\/div><\/div>\n\n\n\n

The Unknome and DARPA<\/strong><\/h2>\n\n\n\n

The US Government agency DARPA have launched an Advanced Research Concept called \u201cDiscovering Unknome Function\u201d which invites applicants to submit ideas for high-throughput prediction of gene function.  More information can be found here:  https:\/\/www.darpa.mil\/ARC\/DUF<\/a>
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How Can AI Influence Genome Research?<\/strong><\/h2>\n\n\n\n

This is exactly the question the Unknome team asked. Therefore, Tim Stevens and Sean Munro are now in the midst of using machine learning\/AI to try and predict the functions of some of the genes in the Unnkome. They are using powerful Neural Networks, to learn about the properties that 2 proteins can share if acting in the same process. This in turn allows them to use said networks to identify the unknown proteins (the Unknome) that either act, or are part of complexes, with other known proteins.<\/p>\n\n\n\n

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The Faces Behind The Unknome<\/h2>\n\n\n\n

Although Sean Munro and Mathew Freeman weren\u2019t the only people behind the Unknome, they were the Main two.<\/p>\n<\/div><\/div><\/div>\n\n\n\n

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Sean Munro<\/h2>

Co-Leader <\/p>

Sean has been a group leader at the LMB since 1989, and the in his lab has addressed protein retention in the Golgi, cannabinoid receptors, protein glycosylation, doubting lipid rafts, Rab and Arf GTPases, and vesicle tethering.<\/div>