refmac5 > refmac_log.txt \
    XYZIN 1ryx.pdb  \
    HKLIN 1ryx.mtz  \
    XYZOUT pdb_out.pdb \
    HKLOUT mtz_out.mtz \
<<EOF
MAKE -
    HYDROGEN NO -
    NEWLIGAND CONTINUE
NCYC 40
EXTERNAL WEIGHT SCALE 10
EXTERNAL WEIGHT GMWT 0.02
EXTERNAL DMAX 4.2
@1ryx.txt
MONI DIST 1000000
END
EOF