{"id":47,"date":"2017-06-08T14:59:33","date_gmt":"2017-06-08T13:59:33","guid":{"rendered":"http:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/?page_id=47"},"modified":"2017-11-14T13:33:10","modified_gmt":"2017-11-14T13:33:10","slug":"structure-gallery","status":"publish","type":"page","link":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/structure-gallery\/","title":{"rendered":"Structure Gallery"},"content":{"rendered":"<style type=\"text\/css\">\n#foogallery-gallery-172 .fg-image { width: 250px; }\n#foogallery-gallery-172 { --fg-gutter: 10px; }<\/style>\n\t\t\t<div class=\"foogallery foogallery-container foogallery-default foogallery-lightbox-foobox fg-center fg-default fg-ready fg-light fg-border-thin fg-shadow-outline fg-loading-default fg-loaded-fade-in fg-caption-hover fg-hover-fade fg-hover-zoom\" id=\"foogallery-gallery-172\" data-foogallery=\"{&quot;item&quot;:{&quot;showCaptionTitle&quot;:true,&quot;showCaptionDescription&quot;:true},&quot;lazy&quot;:true}\" style=\"--fg-title-line-clamp: 0; --fg-description-line-clamp: 0;\" >\n\t<div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/U1_snRNP.png\" data-caption-title=\"U1 snRNP\" data-attachment-id=\"176\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img fetchpriority=\"high\" decoding=\"async\" title=\"The human U1 snRNP recognises the 5&#039; splice site. Solved by X-ray crystallography. PDB 3CW1, 4PJO, 4PKD\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/U1_snRNP\/269400719.png\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">U1 snRNP<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/A-complex.jpg\" data-caption-title=\"A complex\" data-attachment-id=\"219\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img decoding=\"async\" alt=\"Two alternative splicing factors\" title=\"Two large RNA-protein complexes, U1 snRNP (magenta) and U2 snRNP (green), associate to bring two important parts of the intron (black) together.  They later react with each other to cut the first exon and form a lasso-like looped structure of the intron.  Yeast U1 snRNP is much larger than the human counterpart and contains two proteins which are similar to human alternative splicing factors.  These built-in alternative splicing factors facilitate a search for weak intron signals.\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/A-complex\/1771062078.jpg\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">A complex<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/ytrisnRNP.png\" data-caption-title=\"Yeast U5.U4\/U6 tri-snRNP\" data-attachment-id=\"259\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img decoding=\"async\" title=\"The largest pre-assembled component of the spliceosome. Our first cryoEM structure. PDB 5GAN\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/ytrisnRNP\/1269007661.png\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">Yeast U5.U4\/U6 tri-snRNP<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/htrisnRNP_highres.png\" data-caption-title=\"Human U5.U4\/U6 tri-snRNP\" data-attachment-id=\"260\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img decoding=\"async\" title=\"Originally visualised by the Luhrmann\/Stark groups at 7 angstrom resolution, we recently obtained a structure of the human tri-snRNP at 2.9 angstrom resolution, our highest resolution cryo-EM structure. PDB ID 6QW6\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/htrisnRNP_highres\/3805806245.png\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">Human U5.U4\/U6 tri-snRNP<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/2k.png\" data-caption-title=\"Human pre-B complex\" data-attachment-id=\"254\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img decoding=\"async\" title=\"The human pre-B complex, stalled prior to 5&#039; splice site transfer. PDB ID 6QX9\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/2k\/113738750.png\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">Human pre-B complex<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/Bcomplex.png\" data-caption-title=\"B complex\" data-attachment-id=\"142\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img decoding=\"async\" alt=\"Pre-catalytic spliceosome\" title=\"The pre-catalytic spliceosome. Solved by cryoEM. PDB 5NRL\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/Bcomplex\/121845322.png\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">B complex<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/C.png\" data-caption-title=\"C complex\" data-attachment-id=\"173\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img decoding=\"async\" title=\"The spliceosome captured immediately after branching. Solved by cryoEM. PDB 5LJ5\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/C\/1837035005.png\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">C complex<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/yCstar_v2.png\" data-caption-title=\"C* complex\" data-attachment-id=\"255\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img decoding=\"async\" title=\"The spliceosome immediately before exon ligation. Solved by cryoEM. PDB 5MQ0\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/yCstar_v2\/2046967750.png\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">C* complex<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/sidewaysRNA_IS2.png\" data-caption-title=\"P complex\" data-attachment-id=\"186\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img decoding=\"async\" title=\"The active site of the P complex, showing how the 3&#039; splice site (black) is recognised by the branched lariat intron (grey). PDB 6EXN\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/sidewaysRNA_IS2\/1281892502.png\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">P complex<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><div class=\"fg-item fg-type-image fg-idle\"><figure class=\"fg-item-inner\"><a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/hP3kpng.png\" data-caption-title=\"Human P complex\" data-attachment-id=\"257\" data-type=\"image\" class=\"fg-thumb\"><span class=\"fg-image-wrap\"><img decoding=\"async\" title=\"Human P complex immediately after exon ligation. PDB ID 6QDV\" width=\"250\" height=\"250\" class=\"skip-lazy fg-image\" data-src-fg=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-content\/uploads\/sites\/18\/cache\/hP3kpng\/4097119012.png\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20width%3D%22250%22%20height%3D%22250%22%20viewBox%3D%220%200%20250%20250%22%3E%3C%2Fsvg%3E\" loading=\"eager\"><\/span><span class=\"fg-image-overlay\"><\/span><\/a><figcaption class=\"fg-caption\"><div class=\"fg-caption-inner\"><div class=\"fg-caption-title\">Human P complex<\/div><\/div><\/figcaption><\/figure><div class=\"fg-loader\"><\/div><\/div><\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"class_list":{"0":"post-47","1":"page","2":"type-page","3":"status-publish","5":"entry"},"_links":{"self":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-json\/wp\/v2\/pages\/47","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-json\/wp\/v2\/comments?post=47"}],"version-history":[{"count":3,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-json\/wp\/v2\/pages\/47\/revisions"}],"predecessor-version":[{"id":178,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-json\/wp\/v2\/pages\/47\/revisions\/178"}],"wp:attachment":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/nagai\/wp-json\/wp\/v2\/media?parent=47"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}