NEXT GENERATION BIOPHYSICS
Wednesday 3rd October 2018
MRC Laboratory of Molecular Biology, Cambridge
An informal one day meeting organised by Astra Zeneca, MRC LMB and Imperial College London examining the application of cutting edge biophysical techniques in complex biological settings. Bringing together scientists in both academia and industry for stimulating talks and discussions how these new and emerging technologies may be able to address challenging questions in the future.
9.00 – 9.25 Arrive
9.25 –Welcome / Introduction by Mike Snowden, Head of Discovery Sciences, AstraZeneca
Nucleic Acid Enzymes and Machines
9.30 – Ben Taylor, AstraZeneca, Cambridge: DNA bubbles induce Cas9 off-target cutting
10.00 – Mark Dillingham, School of Biochemistry, Bristol : The dynamic architecture of ParB-DNA complexes and their role in bacterial chromosome segregation
10.30 – Achillefs Kapanidis, Dept of Physics, Oxford: Discovering transcription mechanisms via single-molecule imaging in vitro and in vivo
11.00 – 11.30 Coffee
11.30 – Perdita Barran, School of Chemistry, Manchester : Using Mass Spectrometry to study IDPs – The perfect tool to examine self-solvation and fuzzy complexes.
12.00 – Sergi Garcia-Manyes, Kings College, London : The mechanical stability of proteins regulates their translocation rate into the cell nucleus.
12.30 – Justin Benesch, Dept of Chemistry, Oxford : Weighing the evidence for the assembly and dynamics of proteins.
1.00 – 2.00 – Lunch
2.00 – Mark Leake, Dept of Physics, York: Illuminating the black box of DNA-Protein Interactions
2.30 – Philipp Kukura, Dept of Chemistry, Oxford : Weighing single molecules with light
3.00 – Steven Lee, Dept of Chemistry, Cambridge : Multidimensional Super-resolution Imaging
3.30 – 4.00 Coffee
Recognition and Signalling
4.00 – Marisa Martin-Fernandez, STFC Central Laser Facility, Harwell : The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
4.30 – Isabel Llorente-Garcia, Dept Physics and Astronomy, UCL, London : Investigating molecular interactions relevant to virus entry in living cells via optical tweezers force spectroscopy and light-sheet fluorescence microscopy
5.00 – Richard Henderson, LMB, Cambridge: Single Particle cryoEM technology
5.45 Close of Meeting by Jan Lowe, Director of the LMB