{"id":58,"date":"2014-09-15T15:22:10","date_gmt":"2014-09-15T15:22:10","guid":{"rendered":"http:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/full_publications\/"},"modified":"2026-05-05T13:55:42","modified_gmt":"2026-05-05T12:55:42","slug":"full_publications","status":"publish","type":"page","link":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/publications\/full_publications\/","title":{"rendered":"full Publications"},"content":{"rendered":"

Recent publications:<\/h2>\n
\n

Albacete-Albacete L**, Jin L, Sato N, Shahbazi MN and Bullock SL** (2026) Dynein-dependent positioning of multiple organelles regulates adaptive gene expression during oxidative stress. <\/strong>bioRxiv doi: 10.64898\/2026.03.17.712024. Preprint.<\/a> <\/span><\/p>\n

Singh K*, Chilaeva S*, McClintock MA* **, Carter AP** and Bullock SL** (2025) Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization.<\/strong> Nat Struct Mol Biol, doi: 10.1038\/s41594-026-01794-8<\/a><\/p>\n

Zein-Sabatto H, Brockett JS, Jin L, Husbands CA, Lee J, Fang J, Buehler J, Bullock SL** and Lerit DA** (2024) Centrocortin potentiates co-translational localization of its mRNA to the centrosome via dynein. <\/strong>bioRxiv doi: 10.1101\/2024.08.09.607365. <\/em>Preprint.<\/a><\/p>\n

Salvador-Garcia D, Jin L, Hensley A, G\u00f6lc\u00fck M, Gallaud E, Chaaban S, Port F, Vagnoni A, Planelles-Herrero VJ, McClintock MA, Derivery E, Carter AP, Giet R, G\u00fcr M, Yildiz A and Bullock SL (2024) A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression. <\/strong>J Cell Biol, 223 (10): e202310022<\/span>. Pubmed<\/a>.<\/p>\n

Wong CH, Wingett SW, Qian C, Hunter M, Taliaferro JM, Ross-Thriepland D** and Bullock SL** (2024) Genome-scale requirements for dynein-based transport revealed by a high-content arrayed CRISPR screen<\/strong>. J Cell Biol, 223 (5): e202306048. Pubmed<\/a><\/p>\n

Heber S*, McClintock MA*, Simon B, Mehtab E, Lapouge K, Hennig J, Bullock SL** and Ephrussi A** (2024) Tropomyosin 1-I\/C co-ordinates kinesin-1 and dynein motors during oskar<\/em> mRNA transport.<\/strong> Nat Struct Mol Biol. doi: 10.1038\/s41594-024-01212-x<\/span>. Pubmed<\/a><\/p>\n

Madan V, Albacete Albacete L*, Jin L*, Scaturro P, Watson JL, Muschalik N, Begum F, Boulanger J, Bauer K, Kiebler MA, Derivery E and Bullock SL (2023) HEATR5B associates with dynein-dynactin and selectively promotes motility of endosomal membranes. <\/strong>EMBO J, 42: e114473. Pubmed <\/a><\/p>\n

Gaspar I**, Phea LJ, McClintock MA, Heber S, Bullock SL** and Ephrussi A** (2023) An RNA-based feed-forward loop ensures motor switching in oskar <\/em>mRNA transport. <\/strong>J Cell Biol 10.1083\/jcb.202301113<\/span>. Pubmed<\/a><\/p>\n

Fumagalli L*, Young FL*, Boeynaems S*, De Decker M, Mehta AR, Swijsen A, Fazal R, Guo W, Moisse M, Beckers J, Dedeene L, Selvaraj BT, Vandoorne T, Madan V, van Blitterswijk M, Raitcheva D, McCampbell A, Poesen K, Gitler AD, Koch P, Vanden Berghe P, Thal DR, Verfaillie C, Chandran S, Van Den Bosch L, Bullock SL**, Van Damme P** (2020)\u00a0C9orf72<\/em>-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility. <\/strong>Science Advances. doi\/10.1126\/sciadv.abg3013. Pubmed<\/a><\/p>\n

Vincent J**, Preston M, Mouchet E, Laugier N, Corrigan A, Boulanger J, Brown DG, Clark R, Wigglesworth M, Carter AP and Bullock SL** (2020) A High-Throughput Cellular Screening Assay for Small-Molecule Inhibitors and Activators of Cytoplasmic Dynein-1-Based Cargo Transport.<\/strong> SLAS Discovery. doi: 10.1177\/2472555220920581. Pubmed<\/a><\/p>\n

Elshenawy MM, Kusakci E, Volz S, Baumbach J, Bullock SL, Yildiz A (2020) Lis1 activates dynein motility by modulating its pairing with dynactin.<\/strong> Nat Cell Biol. 22(5):570-578. doi: 10.1038\/s41556-020-0501-4. Epub 2020 Apr 27. Pubmed<\/a><\/p>\n

McClintock MA, Dix CI, Johnson CM, McLaughlin SH, Maizels RJ, Hoang HT and Bullock SL (2018) RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs.<\/strong> eLife<\/span>. 2018 Jun 26;7. pii: e36312. doi: 10.7554\/eLife.36312. Pubmed<\/a><\/p>\n<\/div>\n

Vagnoni A** and Bullock SL** (2018) A cAMP\/PKA\/kinesin-1 axis promotes the axonal transport of mitochondria in aging Drosophila<\/em> neurons.<\/strong> Curr Biol<\/span>., 28: 1265-1272. Pubmed<\/a><\/p>\n

Baumbach J, Murthy A*, McClintock MA*, Dix, CI, Zalyte, R, Hoang, HT, Bullock, SL (2017) Lissencephaly-1 is a context-dependent regulator of the human dynein complex.<\/strong> eLife, 6: e21768.\u00a0doi: 10.7554\/eLife.21768. Pubmed<\/a><\/p>\n

Hoang HT, Schlager MA, Carter AP and Bullock SL (2017) DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein-dynactin-cargo adaptor complexes<\/strong>. PNAS, 114: E1597-E1606. Pubmed<\/a><\/p>\n

Port F** and Bullock SL** (2016) Augmenting CRISPR applications in Drosophila <\/em>with tRNA-flanked sgRNAs. <\/strong>Nat Methods, doi:10.1038\/nmeth.3972. PDF<\/a><\/p>\n

Vagnoni A** and Bullock SL** (2016) A simple method for imaging axonal transport in aging neurons using the adult Drosophila<\/em> wing.<\/strong> Nat Protocols, 11(9): 1711-1723. PDF.<\/a><\/p>\n

Vagnoni A, Hoffmann P and Bullock S.L. (2016) Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila <\/em>neurons<\/strong>. J Cell Sci, <\/em>doi: 10.1242\/jcs.179184. Pubmed<\/a><\/p>\n

Port F*(**), Muschalik N* and Bullock SL** (2015) Systematic evaluation of Drosophila<\/em> CRISPR tools reveals safe and efficient alternatives to autonomous gene drives in basic research<\/strong>. G3, 5(7):1493-1502. Pubmed<\/a><\/p>\n

Rossor AM, Oates EC, Salter HK, Liu Y, Murphy SM, Schule R, Gonzalez MA, Scoto M, Phadke R, Sewry CA, Houlden H, Jordanova A, Tournev I, Chamova T, Litvinenko I, Zuchner S, Herrmann DN, Blake J, Sowden JE, Acsadi G, Rodriguez ML, Menezes MP, Clarke NF, Auer Grumbach M, Bullock SL, Muntoni F, Reilly MM, North KN (2015) Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2.<\/strong> Brain, 138 (Pt2):293-310. Pubmed<\/a><\/p>\n

Port F**, Chen HM, Lee T, Bullock SL** (2014) Optimized CRISPR\/Cas tools for efficient germline and somatic genome engineering in Drosophila<\/em>.<\/strong> PNAS, 111(29):E2967-76. doi: 10.1073\/pnas.1405500111. Pubmed<\/a><\/p>\n

Schlager MA*, Hoang HT*, Urnavicius L, Bullock SL**, Carter AP**. (2014) In vitro reconstitution of a highly processive recombinant human dynein complex.<\/strong> EMBO J, 33(17):1855-1868. doi: 10.15252\/embj.201488792.Pubmed<\/a><\/p>\n

Soundararajan HC and Bullock SL (2014) The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA.<\/strong> Elife., e01596. doi: 10.7554\/eLife.01596. Pubmed<\/a><\/p>\n

Dix CI, Soundararajan HC, Dzhindzhev NS, Begum F, Suter B, Ohkura H, Stephens E and Bullock SL (2013) Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs.<\/strong> J Cell Biol. 202(3): 479-494 Pubmed<\/a><\/p>\n

Liu Y*, Salter HK*, Holding AN, Johnson CM, Lukavsky PJ, Walshaw J and Bullock SL (2013) Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein.<\/strong>Genes Dev, 27: 1233-1246 Pubmed<\/a><\/p>\n

Amrute-Nayak M and Bullock SL (2012) Single-molecule assays reveal that RNA localization signals regulate dynein\/dynactin copy number on individual transcript cargoes.<\/strong> Nat Cell Biol, 14(4):416-423. Pubmed<\/a><\/p>\n

Bianco A, Dienstbier M, Salter HK, Gatto G and Bullock SL (2010) Bicaudal-D regulates FMRP levels, motility, and function during neuronal morphogenesis.<\/strong> Curr Biol, 20: 1487-1492. Pubmed<\/a><\/p>\n

Bullock SL*, Ringel I*, Ish-Horowicz D and Lukavsky PJ*. (2010) A\u2019-form RNA helices are required for cytoplasmic mRNA transport in Drosophila<\/em>.<\/strong> Nat Struct Mol Biol, 17: 703-709. Pubmed<\/a><\/p>\n

Li X, Kuromi H, Briggs L, Green DB, Rocha JJ, Sweeney ST and Bullock SL (2010) Bicaudal-D binds clathrin heavy chain to promotes its transport and augments synaptic vesicle recycling.<\/strong> EMBO J, 29: 992-1006. Pubmed<\/a><\/p>\n

Navarro C., Bullock S and Lehmann R. (2009). Altered dynein-dependent transport in piRNA pathway mutants.<\/strong>PNAS, 106: 9691-9696. Pubmed<\/a><\/p>\n

Dienstbier M, Boehl F., Li X and Bullock SL (2009). Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor.<\/strong> Genes Dev, 23: 1546-1558. Pubmed<\/a><\/p>\n

Bullock SL**, Nicol A, Gross, S, and Zicha D (2006). Guidance of bidirectional motor complexes by mRNA cargoes through control of dynein number and activity.<\/strong> Curr Biol. 16: 1447-52. Pubmed<\/a><\/p>\n

Reviews:<\/h2>\n

Mofatteh M and Bullock SL (2017) Subcellular mRNA localization.<\/strong> Cell, <\/em>169:178-178 (SnapShot). Pubmed<\/a><\/p>\n

Holt, C.E. and Bullock, S.L. (2009) Subcellular mRNA localization in animal cells and why it matters.<\/strong> Science, 326: 1212-1216 Pubmed<\/a><\/p>\n

Bullock S.L. (2007) Translocation of mRNAs by molecular motors: think complex?<\/strong> Sem. Cell Dev. Biol. 8:194-201Pubmed<\/a><\/p>\n

Publications from earlier work:<\/h2>\n

Snee M.J., Arn E.A., Bullock S.L. and Macdonald P.M. (2005). Recognition of the bcd mRNA localization signal in Drosophila embryos and ovaries.<\/strong> Mol Cell Biol. 25: 1501-10.<\/p>\n

Hughes J.R., Bullock S.L. and Ish-Horowicz, D. (2004) Inscuteable mRNA localization is dynein-dependent and regulates apico-basal polarity and spindle length in Drosophila neuroblasts.<\/strong> Curr. Biol. 14: 1950-6.<\/p>\n

Bullock S.L.*, Stauber M.*, Prell A., Hughes J.R., Ish-Horowicz, D. and Schmidt-Ott, U. (2004) Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolution.<\/strong> Development 131: 4251-61.<\/p>\n

McLaughlin D., Karlsson F., Tian N., Pratt T., Bullock S.L., Wilson V.A., Price D.J. and Mason J.O. (2003) Specific modification of heparan sulphate is required for normal cerebral cortical development.<\/strong> Mech Dev. 12:1481-8<\/p>\n

Bullock S.L., Zicha D. and Ish-Horowicz, D. (2003) The Drosophila hairy RNA localization signal modulates the kinetics of cytoplasmic mRNA transport.<\/strong> EMBO J. 22: 2484-94<\/p>\n

Houzelstein D.*, Bullock S.L.*, Lynch, D.E., Grigorieva E.F., Wilson V.A. and Beddington R.S.P. (2002) Growth and early post implantation defects in mice deficient for the bromodomain-containing protein Brd4.<\/strong> Mol. Cell. Biol.22: 3794-3802<\/p>\n

Bullock S.L. and Ish-Horowicz D. (2002) Cell polarity: Oskar seeks PARtner for a stable relationship.<\/strong> Nature Cell. Biol. 4: E117-118<\/p>\n

Bullock S.L. and Ish-Horowicz, D. (2001) Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis.<\/strong> Nature 414: 611-616<\/p>\n

Bullock S.L.*, Johnson T.*, Bao Q., Hughes R.C., Winyard P.J.D. and Woolf, A.S. (2001) Galectin-3 modulates ureteric bud branching in organ culture of the developing mouse kidney.<\/strong> J. Am. Soc. Nephrol. 12: 515-23.<\/p>\n

Merry C.L.R., Bullock S.L., Swan D.C., Lyon M., Beddington R.S.P., Wilson V.A. and Gallagher J.T. (2001). The molecular phenotype of heparan sulfate in the Hs2st -\/- mutant mouse.<\/strong> J. Biol. Chem. 276: 35429-3.<\/p>\n

Bullock S.L.. (2001) The art of the comprehensible.<\/strong> Nature Cell. Biol. 3: E236.<\/p>\n

Ott M.-O and Bullock S.L.. (2001). A gene trap insertion reveals that amyloid precursor protein expression is a very early event in murine embryogenesis.<\/strong> Dev. Genes Evol. 7: 355-7<\/p>\n

Bullock S.L., Fletcher J.M., Beddington R.S.P. and Wilson V.A. (1998) Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase.<\/strong> Genes Dev. 12: 1894-1906.<\/p>\n

Bullock S. (1997) The genetic control of development.<\/strong> Bioessays 19: 531-532.<\/p>\n

Policy Forum:<\/h2>\n

Akbari BO, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt K, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O’Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J (2015) Biosafety: Safeguarding gene drive experiments in the laboratory.<\/strong> Science, 349(6241):927-9 Pubmed<\/a><\/p>\n

* These two authors contributed equally ** First and corresponding author<\/p>\n","protected":false},"excerpt":{"rendered":"

Recent publications: Albacete-Albacete L**, Jin L, Sato N, Shahbazi MN and Bullock SL** (2026) Dynein-dependent positioning of multiple organelles regulates adaptive gene expression during oxidative stress. bioRxiv doi: 10.64898\/2026.03.17.712024. Preprint. Singh K*, Chilaeva S*, McClintock MA* **, Carter AP** and Bullock SL** (2025) Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":29,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"class_list":{"0":"post-58","1":"page","2":"type-page","3":"status-publish","5":"entry"},"_links":{"self":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/wp-json\/wp\/v2\/pages\/58","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/wp-json\/wp\/v2\/comments?post=58"}],"version-history":[{"count":34,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/wp-json\/wp\/v2\/pages\/58\/revisions"}],"predecessor-version":[{"id":1350,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/wp-json\/wp\/v2\/pages\/58\/revisions\/1350"}],"up":[{"embeddable":true,"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/wp-json\/wp\/v2\/pages\/29"}],"wp:attachment":[{"href":"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/sbullock\/wp-json\/wp\/v2\/media?parent=58"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}