Jason Chin

Project 1: Orthogonal translation of unnatural polymers
Group Leader page

The aim of this project is to develop foundational technologies to convert the cellular protein synthesis machinery into a factory for the synthesis of unnatural polymers.  The project will involve engineering cells, and evolving key cellular systems for unnatural polymer synthesis.


References:

Chin, J.W. (2017)
Expanding and Reprogamming the Genetic Code.
Nature. 550: 53-60

Wang, K., Fredens, J., Brunner, S. F.,  Kim, S. H.,  Chia, T. and  Chin, J. W. (2016)
Defining synonymous codon compression schemes by genome recoding.
Nature.  539:59-64

Fried, S., Schmied, W., Uttamapinnant, C., Chin, J.W. (2015)
Ribosome subunit stapling for orthogonal translation in E. coli. 
Angew Chem DOI: 10.1002/anie.201506311

Wang, K., Sachdeva, A., Cox, D.J., Wilf, N.M., Lang, K., Wallace, S., Mehl, R.A. and Chin, J.W. (2014)
Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET.
Nat Chem. 6(5):393-403.

Neumann, H., Wang, K., Davis, L., Garcia-Alai, M. and Chin, J.W. (2010)
Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome.
Nature. 464(7287):441-4.

Wang, K., Neumann, H., Peak-Chew, S.Y. and Chin, J.W. (2007)
Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion.
Nat Biotechnol. 25(7):770-7.

Rackham, O. and Chin, J.W. (2005)
A network of orthogonal ribosome x mRNA pairs.
Nat Chem Biol. 1(3):159-66.