Jason Chin

Project 1: Orthogonal translation of unnatural polymers
Group Leader page

The aim of this project is to develop foundational technologies to convert the cellular protein synthesis machinery into a factory for the synthesis of unnatural polymers.  The project will involve engineering cells, and evolving key cellular systems for unnatural polymer synthesis.


Chin, J.W. (2017)
Expanding and Reprogamming the Genetic Code.
Nature. 550: 53-60

Wang, K., Fredens, J., Brunner, S. F.,  Kim, S. H.,  Chia, T. and  Chin, J. W. (2016)
Defining synonymous codon compression schemes by genome recoding.
Nature.  539:59-64

Fried, S., Schmied, W., Uttamapinnant, C., Chin, J.W. (2015)
Ribosome subunit stapling for orthogonal translation in E. coli. 
Angew Chem DOI: 10.1002/anie.201506311

Wang, K., Sachdeva, A., Cox, D.J., Wilf, N.M., Lang, K., Wallace, S., Mehl, R.A. and Chin, J.W. (2014)
Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET.
Nat Chem. 6(5):393-403.

Neumann, H., Wang, K., Davis, L., Garcia-Alai, M. and Chin, J.W. (2010)
Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome.
Nature. 464(7287):441-4.

Wang, K., Neumann, H., Peak-Chew, S.Y. and Chin, J.W. (2007)
Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion.
Nat Biotechnol. 25(7):770-7.

Rackham, O. and Chin, J.W. (2005)
A network of orthogonal ribosome x mRNA pairs.
Nat Chem Biol. 1(3):159-66.