Structure and function of ribosomes
Group Leader page
We are currently studying several aspects of translation by ribosomes and its regulation in the cell. The three main areas are:
- Initiation of translation in eukaryotes and its regulation.
- Translation in the synthesis of mitochondrial proteins.
- Regulation of translation by the cell in abnormal situations.
These studies will use a combination of biochemical and structural methods, including single-particle cryoEM.
Desai, N., Brown, A., Amunts, A., and Ramakrishnan, V. (2017)
The structure of the yeast mitochondrial ribosome.
Science, 355, 528-531.
Hussain, T., Llácer, J. L., Wimberly, B. T., Kieft, J. S., and Ramakrishnan, V. (2016)
Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Cell, 167, 133-144.e13.
Amunts, A., Brown, A., Toots, J., Scheres, S. H., and Ramakrishnan, V. (2015)
The structure of the human mitochondrial ribosome.
Science, 348, 95-98.
Brown, A., Shao, S., Murray, J., Hegde, R. S., and Ramakrishnan, V. (2015)
Structural basis for stop codon recognition in eukaryotes.
Nature, 524, 493-496.