Venki Ramakrishnan

Structure and function of ribosomes
Group Leader page

We are currently studying several aspects of translation by ribosomes and its regulation in the cell. The three main areas are:

  1. Initiation of translation in eukaryotes and its regulation.
  2. Translation in the synthesis of mitochondrial proteins.
  3. Regulation of translation by the cell in abnormal situations.

These studies will use a combination of biochemical and structural methods, including single-particle cryoEM.


References:

Desai, N., Brown, A., Amunts, A., and Ramakrishnan, V. (2017)
The structure of the yeast mitochondrial ribosome.
Science, 355, 528-531.

Hussain, T., Llácer, J. L., Wimberly, B. T., Kieft, J. S., and Ramakrishnan, V. (2016)
Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Cell, 167, 133-144.e13.

Amunts, A., Brown, A., Toots, J., Scheres, S. H., and Ramakrishnan, V. (2015)
The structure of the human mitochondrial ribosome.
Science, 348, 95-98.

Brown, A., Shao, S., Murray, J., Hegde, R. S., and Ramakrishnan, V. (2015)
Structural basis for stop codon recognition in eukaryotes.
Nature, 524, 493-496.