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List of 20 most significant publications

  1. A short adaptive path from DNA to RNA polymerases.
    Cozens C, Pinheiro VB, Vaisman A, Woodgate R, Holliger P.
    Proc Natl Acad Sci U S A. 2012; 109 : 8067-72.
    (F1000: 2*)
  2. Synthetic genetic polymers capable of heredity and evolution.
    Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P, Holliger P.
    Science. 2012; 336 : 341-4.
    (F1000: 11*, featured in Nature, Nature Methods, Nature Biotechnology, Scientific American, New Scientist, NASA Astrobiology, RSc Chemistry World etc.)
  3. Ribozyme-catalyzed transcription of an active ribozyme.
    Wochner A, Attwater J, Coulson A, Holliger P.
    Science. 2011; 332 :209-12.
    (F1000: 14*, featured in Nature, Nature Methods, New Scientist, RSc Chemistry World, ChemEng News)
  4. Molecular breeding of polymerases for resistance to environmental inhibitors.
    Baar C, d'Abbadie M, Vaisman A, Arana ME, Hofreiter M, Woodgate R, Kunkel TA, Holliger P.
    Nucleic Acids Res. 2011 ; 39 :e51
    (featured in Biotechniques)
  5. Ice as a protocellular medium for RNA replication.
    Attwater J, Wochner A, Pinheiro VB, Coulson A, Holliger P.
    Nat Commun. 2010; 1: 76. doi: 10.1038/ncomms1076
    (F1000: 2*, featured in New Scientist, Discover, Wired and BBC4)
  6. CyDNA: synthesis and replication of highly Cy-dye substituted DNA by an evolved polymerase.
    Ramsay N, Jemth AS, Brown A, Crampton N, Dear P, Holliger P.
    J Am Chem Soc. 2010; 132 :5096-104. (featured in ACS Chemical Biology)
  7. Evolving a polymerase for hydrophobic base analogues.
    Loakes D, Gallego J, Pinheiro VB, Kool ET, Holliger P.
    J Am Chem Soc. 2009 ; 131 :14827-37
  8. Molecular breeding of polymerases for amplification of ancient DNA.
    d'Abbadie M, Hofreiter M, Vaisman A, Loakes D, Gasparutto D, Cadet J, Woodgate R, Pääbo S, Holliger P.
    Nat Biotechnol. 2007 ; 25 :939-43 (
    (featured in Nat. Biotechnology, Nat. Methods, Trends in Genetics)
  9. Directed evolution of DNA polymerase, RNA polymerase and reverse transcriptase activity in a single polypeptide.
    Ong JL, Loakes D, Jaroslawski S, Too K, Holliger P.
    J Mol Biol. 2006 ; 361 : 537-50
  10. Engineering high affinity superantigens by phage display.
    Enever C, Tomlinson IM, Lund J, Levens M, Holliger P.
    J Mol Biol. 2005 ; 347 :107-20.
  11. Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution.
    Ghadessy FJ, Ramsay N, Boudsocq F, Loakes D, Brown A, Iwai S, Vaisman A, Woodgate R, Holliger P.
    Nat Biotechnol. 2004 ; 22 :755-9. 
  12. A novel emulsion mixture for in vitro compartmentalization of transcription and translation in the rabbit reticulocyte system.
    Ghadessy FJ, Holliger P.
    Protein Eng Des Sel. 2004 ; 17 : 201-4.
  13. Isolation of receptor-ligand pairs by capture of long-lived multivalent interaction complexes.
    de Wildt RM, Tomlinson IM, Ong JL, Holliger P.
    Proc Natl Acad Sci U S A. 2002 ; 99 :8530-5.
  14. Directed evolution of polymerase function by compartmentalized self-replication.
    Ghadessy FJ, Ong JL, Holliger P.
    Proc Natl Acad Sci U S A. 2001 ; 98 :4552-7 
  15. Carcinoembryonic antigen (CEA)-specific T-cell activation in colon carcinoma induced by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti-CEA bispecific fusion proteins.
    Holliger P, Manzke O, Span M, Hawkins R, Fleischmann B, Qinghua L, Wolf J, Diehl V, Cochet O, Winter G, Bohlen H.
    Cancer Res. 1999 ; 59 :2909-16
  16. Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability.
    Holliger P, Riechmann L, Williams RL.
    J Mol Biol. 1999 ; 288 :649-57
  17. The C-terminal domain of TolA is the coreceptor for filamentous phage infection of E. coli.
    Riechmann L, Holliger P.
    Cell. 1997 ; 90 :351-60              
  18. Retargeting serum immunoglobulin with bispecific diabodies.
    Holliger P, Wing M, Pound JD, Bohlen H, Winter G.
    Nat Biotechnol. 1997 ; 15 : 632-6
  19. A conserved infection pathway for filamentous bacteriophages is suggested by the structure of the membrane penetration domain of the minor coat protein g3p from phage fd.
    Holliger P, Riechmann L.
    Structure. 1997 ; 5 :265-75
  20. "Diabodies": small bivalent and bispecific antibody fragments.
    Holliger P, Prospero T, Winter G.
    Proc Natl Acad Sci U S A. 1993 ; 90 : 6444-8