- Membrane protein biosynthesis
- Cytosolic quality control
- Quality control at the ribosome
- Diseases of protein misfolding
To learn more, watch Manu’s iBiology talks.
Summary articles of recent key papers:
- Keeping protein subunits in check via assembly quality control (2023)
- Pathway for making multipass membrane proteins elucidated (2022)
- Pathway behind disposal of ‘orphan’ proteins identified (2021)
- Discovery of a new type of chaperone for membrane proteins (2020)
- How cells avoid and resolve ribosome traffic jams (2020)
- Discovery of a factor involved in tubulin autoregulation (2019)
- Key role for EMC during GPCR biogenesis (2018)
- Discovery of ZNF598 as a sensor of ribosome collisions (2018)
- Discovery of EMC as a membrane protein insertase (2017)
- Discovery of UBE2O as a new quality control factor (2017)
- Mechanism of nascent protein triage (2017)
- Signal sequence recognition by the Sec translocon (2016)
- Discovery of Ubiquilins as a family of quality control factors (2016)
- Structural basis of eukaryotic stop codon recognition (2015)
- Structural basis of nascent chain ubiquitination by RQC (2015)
- Atomic resolution structure of a native ribosome-Sec61 complex (2014)