Amy Yewdall


Lori is originally from Canada and studied Biochemistry at the University of British Columbia in Vancouver.  In 1999, she moved to the UK for her PhD studies at The Institute of Cancer Research.  After completing her PhD, Lori moved to Cambridge where she was a Career Development Fellow at the MRC Laboratory of Molecular Biology, funded by a Beit Memorial Fellowship for Medical Research.  In 2009, Lori became a Group Leader at the MRC-LMB. She is also a fellow of Clare Hall.

Lori was awarded an ERC Starting Grant in 2011 and an ERC Consolidator Grant in 2017. She was elected into the EMBO Young Investigator Programme in 2015 and EMBO Membership in 2018.

For more details see Lori’s CV.

Twitter: @lapassmore


Passmore Lab, MRC Laboratory of Molecular Biology, Cambridge UK

Lori A. Passmore, PhD 

Group Leader

Lab photos can be found here!

Summer Student 2010

Amy worked in the Passmore lab for three months over the summer after finishing her second year at the University of Cambridge.

She moved on to do a PhD in New Zealand with Juliet Gerrard and is currently a post-doc in Eindhoven.

Twitter: @OodlesOfYewdall

Lab Alumni

Alexander Kögel

MPhil student 2012-2014

Alexander joined us in October 2012 after studying biology at the University of Zurich. Originally from Germany, he is interested in mRNA deadenylation.

He completed his MPhil in the Passmore lab in 2014 and is now a PhD student in Elena Conti’s group at the Max Planck Institute of Biochemistry in Martinsried.

Birthe Meineke, PhD

Post-doctoral Fellow 2012

Birthe completed a PhD with Stewart Shuman at Sloan-Kettering Institute in New York. She studied anticodon nuclease-mediated tRNA damage and its repair. Birthe is originally from Germany and studied at Tübingen.

Birthe worked jointly with Murray Stewart’s lab for one year from Feb 2012.

Currently Post-doc at the Karolinska Institute

Katrin Wiederhold, PhD

Post-doctoral Fellow 2009-2013

Katrin completed her PhD in Protein Biochemistry at the Max Planck Institute for Biophysical Chemistry (Goettingen, Germany). 

She moved to Cambridge and joined the Passmore lab in April 2009 where she studied mRNA polyadenylation and deadenylation.

Currently working at Immunocore.

James Stowell, PhD

PhD student/Post-doc

James studied at the University of York where he gained his passion for structural biology. He worked in Piotr Sliz’s lab (Harvard Medical School) for a year before joining us in October 2013. James is interested in structures of proteins involved in post-transcriptional gene regulation. He finished his PhD in 2017 and is now a post-doc in the lab.

Email: jstowell [at]

Tayla Olsen

Summer Student 2013

Tayla worked in the lab during the summer of 2013 after her third year of university. She studied Biochemistry at the University of Wisconsin, Madison. Tayla was selected to take part in the Summer Cambridge and Oxford Research Experience (SCORE).

Currently a PhD student at University of Washington in Seattle.

Twitter: @TaylaOlsen

December 2021

Ashley Easter

PhD Student 2010-2014

Ashley moved all the way from New Zealand to join the lab in October 2010.  He studied at the University of Waikato and has a background in chemistry and biophysics.

Ashley was funded by a Woolf Fisher Trust PhD Scholarship. He successfully defended his thesis in April 2014. He then moved to a position at Innovia Technology and is now working at AstraZeneca.

Photo credit : MRC (Martin Phelps)

Jana joined the lab in October 2010 after completing her undergraduate and masters studies at the University of Heidelberg.  She is interested in the structure and function of proteins involved in regulating gene expression.

Jana was funded by a LMB Scholarship. She successfully defended her thesis in July 2014 and started a job at Domainex.

Jana Wolf

PhD Student 2010-2014

Gillian is from Canada and studied at Simon Fraser University and the University of Leicester. She started in Nov 2012 and worked with both the Passmore and Carter labs. Gillian set up the Multibac system for expression of multi-protein complexes in insect cells.

Gillian did her PhD at the University of Victoria in Canada and is currently a post-doc in Berlin.

Twitter: @GilleighD

Gillian Dornan

Research Assistant 2012-2014

Fabienne Birkle

Masters student, autumn 2014

Fabienne is studying for her masters degree at the Ruprecht-Karls-University in Heidelberg. She joined the Passmore lab for a 3 month internship in September 2014.

She is now doing a PhD at the University of Michigan

Twitter: @TF_Birkle

Ina Huppertz

PhD student 2012-2015

Ina started her PhD in October 2012 and worked with Jernej Ule’s lab. She defined the RNA binding patterns of specific proteins using CLIP technology. Ina was funded by through a Marie Curie Initial Training Network RNPnet.

She did a post-doc in Mattias Hentze’s lab (EMBL Heidelberg) and is now a Group Leader at the Max Planck Institute for Biology of Ageing.

Twitter: @ina_huppertz

  Kathryn Shelley

Summer student 2015

Kathryn worked in the lab for 3 months with James and Ana. She did TAP purifications from yeast as well as working with RNA binding proteins. Kathryn had just finished her 2nd Year in biochemistry at The Queen's College, Oxford University.

Christopher Russo, PhD

Post-doctoral Fellow 2011-2015

Chris completed his PhD in Applied Physics at Harvard University in the lab of Jene Golovchenko and Daniel Branton. He has specific expertise in electron microscopy and applied this to projects in the Passmore lab.

Chris joined in November 2011 and developed new substrates for cryo-EM. He started his own group at LMB in Jan 2016, supported by an Early Career Fellowship from the Leverhulme Trust.

Now a group leader at MRC LMB


Twitter: @cjrlab

Photo credit : MRC (Martin Phelps)

Peter Kubik

Summer student 2016

Peter worked in the lab after finishing his third year of undergraduate studies. He was a student at University of Edinburgh but spent a year in Canada at UBC on an exchange program. He worked with Chris Hill.

Currently on a Masters program

Terence Tang

PhD student/Post-doc

Terence joined the Passmore group in October 2016 to study mechanisms of mRNA de-adenylation. Prior to this, he studied Biochemistry at the University of Oxford where he developed an interest in structural biology. He finished his PhD in 2020. He was supported by a Hershel Smith studentship.

Terence is now doing a post-doc in Jue Chen’s lab at Rockefeller.

Twitter: @terencetltang

Ann Kelley

Research support 2017

Ann worked in the lab for three months to help out with protein preps and in vitro transcriptions. She previously worked at the LMB with Venki Ramakrishnan.

Eeson Rajendra, PhD

Post-doctoral Fellow 2010-2016

Eeson studied at the University of Cambridge and did his PhD with Ashok Venkitaraman at the MRC/Hutchison Cancer Cell Unit.  He has a specific interest in mechanisms of DNA repair.

Eeson joined us in February 2010 and is purifying complexes from higher eukaryotes. He is working on the FA core complex.

Currently Senior Scientist at Artios Pharma

  Juan Rodríguez Molina, PhD


Juan joined the lab in June 2017. He studied Pol II during his PhD at the University of Wisconsin-Madison in Aseem Ansari’s lab. He is doing functional work in yeast in the Passmore lab.

Email: jrodrigu [at]

Twitter: @rodriguezmol

Vytaute Boreikaite

Summer student 2017/PhD student

Vytaute first joined the lab after her third year at Cambridge University (Queens’ College) as a summer student. She worked on the nuclease activity of CPF with Chris Hill for the summer.

She joined the lab as a PhD student in October 2018 and continues investigating mRNA 3’ end formation.

Email: vborei [at]

Twitter: @VBoreikaite

Chris Hill, PhD

Post-doc 2015 – 2017

Chris Hill joined the lab in August 2015 to work on CPF, focusing on the nuclease. Chris completed his PhD studies in Janet Deane and Randy Read's laboratories at the Cambridge Institute for Medical Research (CIMR) working on structural and functional studies of β-galactocerebrosidase, the defective enzyme in Krabbe disease.

Chris started his own group at the University of York in 2021.


Twitter: @chillzaa

  Manuel Carminati


Manuel joined the lab in January 2018. He did his PhD with Marina Mapelli at the European Institute of Oncology in Milan where he studied the molecular mechanisms driving mitotic spindle orientation. Manuel has been awarded an EMBO long-term fellowship for his work in the lab.

Manuel is now a post-doc in Nico Thomä’s lab at FMI in Basel

Twitter: @_M_Carminati

Pablo Alcón Hernández, PhD


Pablo studied the structure of the Cpf1 CRISPR endonuclease during his PhD with Guillermo Montoya at the University of Copenhagen. He joined the lab in February 2018 to study DNA repair complexes. Pablo was awarded an EMBO long-term fellowship for his work in the lab.

Email: palcon [at]

Twitter: @palconh

Michael Webster, PhD

PhD student/Post-doc 2013-2018

Michael studied at the University of Sydney where he worked in Joel Mackay’s lab. He is specifically interested in RNA binding proteins and gene regulation. Michael joined the lab in October 2013.

He went on to do a post-doc in Albert Weixlbaumer’s lab at IGBMC Strasbourg. Michael started his own lab at the John Innes Centre in 2022.


Twitter: @WebsterMichael0

Alžběta Roeselová

Summer Student 2018

Alžběta worked with Terence on Pan2-Pan3 for 3 months over the summer. She had just finished her second year studying Natural Sciences at the University of Cambridge (Peterhouse College).

Currently a PhD student at the Crick Institute.

Eleanor joined the lab for 3 months over the summer of 2018. She was studying at the University of Cambridge (Peterhouse College) and had just finished her third year.

She worked in the lab with Juan to study the CPF nuclease module using structural and functional approaches. Now a PhD student at the Cancer Research UK Cambridge Institute.

Twitter: @EleanorSheekey


Max Seidel

Masters student 2018-2019

Max joined the lab as a Masters student from University of Heidelberg in October 2018. He studied deadenylation. He was awarded the GBM Master prize for the best thesis in Biochemistry in Heidelberg.

Max started his PhD in Martin Beck’s laboratory in autumn 2019.

  Eleanor Sheekey

Summer Student 2018

Eva Absmeier


Eva joined the lab in summer 2019 to study deadenylase complexes. She completed her PhD with Markus Wahl at Freie Universität Berlin working on RNA helicases of the spliceosome using x-ray crystallography, biophysical and biochemical methods. She is funded by a DFG Research Fellowship.

Email: absmeier [at]

Twitter: @AbsmeierEva

M. Cemre Manav


Cemre completed her PhD in Ditlev Brodersen’s lab at the University of Aarhus where she studied (p)ppGpp synthesis by bacteria. Cemre visited the lab for two months in 2018 to do some electron microscopy and biochemical experiments.

She joined the lab as a post-doc in December 2019 to study poly(A) tail removal. Cemre is funded by a NovoNordisk Foundation Fellowship.

Email: cemremnv [at]

Twitter: @mcemremnv

Ananthanarayanan Kumar

PhD student 2015-2019

Ananth arrived in October 2015 to join the CPF team, with a specific interest in the polyA polymerase. He studied in India and during this time designed a microbial fuel cell. He then did a Masters at Nagoya University in Japan, focussing on bacterial flagella. Ananth was supported by a Gates Cambridge Studentship.

Currently a post-doc with Anna Marie Pyle at Yale.

Twitter: @ananthb3lyp

Tamara Sijacki

PhD student

Tamara studied at the University of Vienna. She joined the lab as a PhD student in October 2019 and is working on the Fanconi Anaemia DNA repair pathway.

Email: tsijacki [at]

Twitter: @TamaraSijacki

Shabih Shakeel, PhD

Post-doc 2017-2020

Shabih did his PhD with Sarah Butcher at the University of Helsinki, studying the structures of picornaviruses and mechanisms of RNA packaging. He joined the Passmore group in April 2017 where he used cryo-EM to study the Fanconi anaemia pathway.

He started his own group at WEHI in Melbourne in 2021.

Twitter: @ShabihShakeel

Ana Casañal, PhD

Post-doc 2014-2020

Ana joined the lab in October 2014 after completing her PhD with Victoriano Valpuesta at the University of Málaga and José Márquez at EMBL Grenoble.

In the Passmore lab, Ana worked on the polymerase module of CPF. She was supported by an EMBO long-term fellowship and was awarded the 2019 Biochemical Society Early Career Award, the 2019 Brenner post-doc prize and the 2019 FEBS Anniversary prize award for her work.

She started her own lab at the Human Technopole in Milan in 2021.

Twitter: @AnaCasanal

Giselle Lee

Summer student 2021

Giselle was a summer student in the lab in 2021. She worked with James on targeted deadenylation on the Ccr4-Not complex. She was in the lab between her third and fourth years at University of Cambridge (Biochemistry).

Now a PhD student in John Diffley’s lab at the Crick Institute.

Twitter: @gsiellecllee

Sigurður Þorkelsson

Visiting student 2021

Siggi is a PhD student in Kay Grünewald’s lab in Hamburg where he is studying the structures of viral proteins essential for transcription and translation. He visited the lab for 2 months in 2021.

Francis O’Reilly

Visiting Scientist 2020

Francis is a post-doc in Juri Rappsilbers lab in Berlin. He is an expert on cross-linking mass spectrometry and collaborates with us. He visited the lab for one month in 2020.

Holly Fagarasan

PhD student

Holly studied at the University of Birmingham. She joined the lab as a PhD student in October 2021. She is studying activation of cleavage by the CPF complex.

Email: hfagarasan [at]

Twitter: @FagarasanHolly

  Timothy Western

Summer Student 2022

Tim was a summer student in the lab in 2022. He worked with Tamara and Pablo on Fanconi Anaemia DNA repair.

Tim studies Molecular and Cellular Biochemistry at the University of Oxford and had just finished his second year.

  Sylvie Agnello

Summer Student 2022

Sylvie was a summer student in the lab in 2022. She worked with James on Ccr4-Not.

Sylvie studies Biomedical Sciences at the University of York and had just finished her second year.

Matti Turtola

Visiting scientist

Matti is a new PI at University of Turku. He is visiting the lab for 2 months to learn how we study mRNA polyadenylation in vitro.