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The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
The ability of scientists to create changes in gene sequences has improved dramatically in recent years with the emergence of a new method, dubbed ‘CRISPR’. This ‘genome editing’ technology is of great interest due to the wide range of possible applications. CRISPR is already commonly used in fundamental research to study the function of specific…
Gene fusions, which occur when two previously separate genes become aberrantly fused together, are common cancer-causing mutations. What remain unknown are the molecular functions of most gene fusions, and the proteins that gene fusions can encode (fusion proteins). This lack of functional understanding is a growing problem, since the number of detected gene fusions in…
- 2016 Milstein Lecture to be given by Yoshinori Ohsumi
Professor Yoshinori Ohsumi will give the 2016 Milstein Lecture on Friday 9th September 2016 at […]
- Apprentices complete their training in the LMB Workshops
The LMB Workshops have a long history of training staff and offering apprenticeships to give […]
- The mammalian dynein-dynactin complex is a strong opponent to kinesin in a tug-of-war competition.
Belyy, V., Schlager, MA., Foster, H., Reimer, AE., Carter, AP., Yildiz, A.
Nat. Cell Biol. 18(9): 1018-24. (25th September 2016)
- Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model.
Khabirova, E., Chen, KF., O'Neill, JS., Crowther, DC.
Sci Rep 6: 33759. (23rd September 2016)
- A novel optical microscope for imaging large embryos and tissue volumes with sub-cellular resolution throughout.
McConnell, G., Trägårdh, J., Amor, R., Dempster, J., Reid, E., Amos, WB.
Elife 5. (23rd September 2016)
- Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.
Hussain, T., Llácer, JL., Wimberly, BT., Kieft, JS., Ramakrishnan, V.
Cell 167(1): 133-144.e13. (22nd September 2016)
- Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration.
Goedert, M., Masuda-Suzukake, M., Falcon, B.
Brain [Epub ahead of print]. (21st September 2016)
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