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About us

The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.

Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.

Insight on research

Detecting and signalling DNA single-strand breaks: understanding the mechanisms of DNA damage recognition

Copyright: Molecular Cell

DNA damage represents a constant threat to the integrity of genomic information in cells and is closely linked to the origins of cancer. DNA single-strand breaks (SSBs) are the most frequent type of damage with thousands of such lesions from different sources occurring in each cell every day. Despite many advances in understanding the mechanistic…

Cryo-EM imaging of ribosomes shows the origin of leukaemia

Photo tag: Cryo-EM structure of the 60S-eIF6-SBDS complex

Ribosomes, the molecular machines in cells that make proteins, are constructed in a series of discrete steps to create both a large and a small subunit. Release of a key building block, eIF6, from the large 60S subunit allows assembly of the mature active ribosome. Alan Warren’s group, at the University of Cambridge, in collaboration…

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Latest publications

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