The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
Dynactin is a protein complex that activates the dynein motor protein, enabling intracellular transport. It is extremely flexible and has proved very difficult to study by conventional crystallography methods. Now for the first time, research carried out by Andrew Carter and his group in the LMB’s Structural Studies Division, has revealed the structure of this…
A research team from the LMB’s Cell Biology division, working with colleagues from the Structural Studies division, has revealed how cells are able to find and tag for degradation the partially synthesised proteins generated when ribosomes occasionally stall. Cells make more than a hundred thousand new proteins every minute. Once in a while, one of…
- LMB scientists help UTC students design a laboratory
Students from the new University Technical College (UTC) Cambridge have been taking part in a […]
- LMB spin-out, Heptares Therapeutics, acquired by Sosei Group
Leading Japanese biopharmaceutical company, Sosei Group Corporation, has acquired the UK-based biotechnology company, Heptares Therapeutics […]
- Cyrus Chothia, bioinformatics pioneer, honoured with two prestigious international awards
Emeritus group leader Cyrus Chothia, from the LMB’s Structural Studies Division, has been honoured with […]
- Brad Amos and John White win ABRF Biomolecular Technologies Award
The 2015 Association of Biomolecular Resource Facilities (ABRF) Award for Annual Outstanding Contributions to Biomolecular […]
- Plug-and-Play Genetic Access to Drosophila Cell Types using Exchangeable Exon Cassettes.
Diao, F., et al.
Cell Rep 10(8): 1410-1421. (3rd March 2015)
- Sequence composition of disordered regions fine-tunes protein half-life.
Fishbain, S., Inobe, T., Israeli, E., Chavali, S., Yu, H., Kago, G., Babu, MM., Matouschek, A.
Nat. Struct. Mol. Biol. 22(3): 214-21. (2nd March 2015)
- Activation of Human γδ T Cells by Cytosolic Interactions of BTN3A1 with Soluble Phosphoantigens and the Cytoskeletal Adaptor Periplakin.
Rhodes, DA., Chen, HC., Price, AJ., Keeble, AH., Davey, MS., James, LC., Eberl, M., Trowsdale, J.
J. Immunol. 194(5): 2390-8. (1st March 2015)
- Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.
Murn, J., et al.
Genes Dev. 29(5): 501-12. (1st March 2015)
- Pillars Article: AID Mutates E. coli Suggesting a DNA Deamination Mechanism for Antibody Diversification. Nature. 2002. 418: 99-103.
Petersen-Mahrt, SK., Harris, RS., Neuberger, MS.
J. Immunol. 194(5): 2043-7. (1st March 2015)
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