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The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
The LMB has always been very diverse, with a truly international outlook. We welcome men and women from over 50 countries, and have alumni all over the world.
Ribosomes are cellular molecular machines that link amino acids together in the order specified by messenger RNA (mRNA) to make proteins. Near the end of the mRNA molecule a specific nucleotide sequence, known as a stop codon, signals for protein synthesis to terminate by recruiting release factors that release the newly made protein from the…
The design and synthesis of genomes provides a powerful approach for understanding and engineering biology. The development of methods that can accurately replace the genome in sections, provide feedback on precisely where a given design fails and on how to repair it, and that can be rapidly repeated for whole genome replacement would accelerate our…
- Cambridge Fire and Rescue Service run training exercise at LMB
The LMB and Cambridge Fire and Rescue Service recently held a joint training exercise, involving […]
- UTCC students have hands-on EM experience at the LMB
The LMB has continued its collaboration with the University Technical College Cambridge (UTCC), with students […]
- The Transcellular Propagation and Intracellular Trafficking of α-Synuclein.
Tofaris, GK., Goedert, M., Spillantini, MG.
Cold Spring Harb Perspect Med [Epub ahead of print]. (5th December 2016)
- Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.
Wiedmann, MM., et al.
Angew. Chem. Int. Ed. Engl. [Epub ahead of print]. (5th December 2016)
- Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium.
Tian, X., et al.
PLoS ONE 11(12): e0167503. (1st December 2016)
- Protein sorting at the ER-Golgi interface.
Gomez-Navarro, N., Miller, E.
J. Cell Biol. [Epub ahead of print]. (30th November 2016)
- Resolving macromolecular structures from electron cryo-tomography data using subtomogram averaging in RELION.
Bharat, TA., Scheres, SH.
Nat Protoc 11(11): 2054-65. (29th November 2016)
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