The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
Work carried out by Lori Passmore’s group in the LMB’s Structural Studies Division, in collaboration with Patrick Cramer’s group in Munich, has revealed how transcription termination and mRNA processing by Cleavage and Polyadenylation Factor (CPF) are coupled via dephosphorylation of the C-terminal domain of RNA Polymerase II by CPF. Genes code for proteins – the […]
Research from Greg Jefferis’s group in the LMB’s Neurobiology Division has uncovered a biological switch that determines which part of the fruit fly’s brain responds to pheromones, depending on whether the fruit fly is male or female. Previous studies have identified differences in brain structure between the sexes but this study, published in Cell, is […]
- Madan Babu awarded the Protein Society’s 2014 Protein Science Young Investigator Award
Madan Babu, from the LMB’s Structural Studies Division, has been announced as the recipient of […]
- LMB raises over £1,700 for the Addenbrooke’s Dialysis Centre
Staff at the LMB have raised over £1,700 from their annual Charity fundraiser for the […]
- Anne Bertolotti awarded the 2014 Hooke Medal
Anne Bertolotti, from the LMB’s Neurobiology Division, has been announced as the British Society for […]
- LMB hosts Feldberg Prize Lecture by Nikolaus Pfanner
Professor Nikolaus Pfanner from the Institute for Biochemistry and Molecular Biology, University of Freiburg, Germany, […]
- Crenactin from Pyrobaculum calidifontis is closely related to actin in structure and forms steep helical filaments.
Izoré, T., Duman, R., Kureisaite-Ciziene, D., Löwe, J.
FEBS Lett. 588(5): 776-82. (3rd March 2014)
- The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons.
Iovino, M., et al.
Acta Neuropathol. 127(2): 283-95. (2nd March 2014)
- LEF1 and B9L Shield β-Catenin from Inactivation by Axin, Desensitizing Colorectal Cancer Cells to Tankyrase Inhibitors.
de la Roche, M., Ibrahim, AE., Mieszczanek, J., Bienz, M.
Cancer Res. 74(5): 1495-505. (1st March 2014)
- Dynamic Behavior of the Active and Inactive States of the Adenosine A2A Receptor.
Lee, S., Bhattacharya, S., Grisshammer, R., Tate, CG., Vaidehi, N.
J Phys Chem B [Epub ahead of print]. (28th February 2014)
- Anti-amyloid compounds inhibit alpha-synuclein aggregation induced by Protein Misfolding Cyclic Amplification (PMCA).
Herva, ME., Zibaee, S., Fraser, G., Barker, RA., Goedert, M., Spillantini, MG.
J. Biol. Chem. [Epub ahead of print]. (28th February 2014)
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