The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
Target of Rapamycin (TOR) is a protein kinase that is essential in maintaining cellular homeostasis. In mammalian cells the enzyme occurs as two large protein complexes and one of these, mTORC1, controls growth of cells by integrating signals from growth factors and the nutritional state of cells. Many tumours in humans are associated with inappropriate…
Most organisms, including humans and plants, have circadian rhythms that allow them to adjust their metabolism and behaviour to match the 24-hour cycle of day and night. Circadian rhythms are even observed at the level of individual cells, and are dependent upon a biological clock mechanism that is not fully understood. Work by John O’Neill’s…
- Ramanujan Hegde elected Fellow of the Royal Society
Manu Hegde, group leader in the LMB’s Cell Biology Division, has been elected as a […]
- Jason Chin elected Fellow of the UK Academy of Medical Sciences
Jason Chin, group leader in the LMB’s PNAC Division, has been elected into the Fellowship […]
- Nonparalytic botulinum molecules for the control of pain.
Mangione, AS., et al.
Pain 157(5): 1045-55. (30th April 2016)
- Structure and organization of heteromeric AMPA-type glutamate receptors.
Herguedas, B., García-Nafría, J., Cais, O., Fernández-Leiro, R., Krieger, J., Ho, H., Greger, IH.
Science 352(6285): aad3873. (29th April 2016)
- Consequences of point mutations in melanoma-associated antigen 4 (MAGE-A4) protein: Insights from structural and biophysical studies.
Hagiwara, Y., et al.
Sci Rep 6: 25182. (28th April 2016)
- Molecular mechanism of APC/C activation by mitotic phosphorylation.
Zhang, S., Chang, L., Alfieri, C., Zhang, Z., Yang, J., Maslen, S., Skehel, M., Barford, D.
Nature [Epub ahead of print]. (27th April 2016)
- Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.
Ziemba, BP., Burke, JE., Masson, G., Williams, RL., Falke, JJ.
Biophys. J. 110(8): 1811-25. (26th April 2016)
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