The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Eleven Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Previous work from KJ Patel’s group in the LMB’s PNAC Division revealed that aldehydes – such as acetaldehyde, a by-product of alcohol metabolism – can damage our DNA. Further research by the group showed that our cells are protected against these toxic…
The human genome encodes approximately 5000 membrane-embedded proteins that carry out many essential processes such as cell-to-cell communication, cell adhesion and intracellular trafficking. Almost all of these proteins are assembled at the endoplasmic reticulum (ER) by molecular machines that guide them into…
- Madan Babu and John Briggs honoured by the Blavatnik Awards
Two LMB group leaders, both from the Structural Studies Division, are honoured by the inaugural […]
- John Kendrew Lecture to be given by Xiaowei Zhuang
Xiaowei Zhuang will give the 2017 John Kendrew Lecture on Monday 15th January 2018 at […]
- Toward an orthogonal central dogma.
Liu, CC., Jewett, MC., Chin, JW., Voigt, CA.
Nat. Chem. Biol. 14(2): 103-106. (16th January 2018)
- Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas.
Kayikci, M., Venkatakrishnan, AJ., Scott-Brown, J., Ravarani, CNJ., Flock, T., Babu, MM.
Nat. Struct. Mol. Biol. [Epub ahead of print]. (15th January 2018)
- The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure.
Hill, CH., Cook, GM., Spratley, SJ., Fawke, S., Graham, SC., Deane, JE.
Nat Commun 9(1): 151. (11th January 2018)
- Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.
Garaycoechea, JI., et al.
Nature 553(7687): 171-177. (11th January 2018)
- Pharmacogenomics of GPCR Drug Targets.
Hauser, AS., Chavali, S., Masuho, I., Jahn, LJ., Martemyanov, KA., Gloriam, DE., Babu, MM.
Cell 172(1-2): 41-54.e19. (11th January 2018)
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