The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
In a long-standing collaborative effort, groups at MRC Harwell, the LMB, and the University of Oxford have discovered a new genetic mechanism in the circadian body clock that could have important implications for research in mental health and psychiatric disease. Biological clocks run in all our cells, controlling the timing of a number of crucial…
Early-onset Parkinson’s disease arises when the Parkin protein, an E3 ubiquitin ligase, cannot be activated and remains in a permanently ‘off’ state in neurons. Despite the importance of Parkin activation, until recently no-one has understood how the protein could be switched on. David Komander’s group, in the LMB’s Protein and Nucleic Acid Chemistry Division, has…
- Staff show their creative side at the LMB Art Exhibition
Nearly 30 LMB staff have shown off their creativity at the annual LMB Art Exhibition, […]
- Madan Babu Mohan awarded the Royal Society Francis Crick Medal and Lecture 2016
Madan Babu Mohan, group leader in the LMB’s Structural Studies Division, has been awarded the […]
- How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse.
Godfrey, C., et al.
Hum. Mol. Genet. 24(15): 4225-37. (1st August 2015)
- The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.
Parsons, MJ., et al.
Cell 162(3): 607-21. (30th July 2015)
- Safeguarding gene drive experiments in the laboratory.
Akbari, BO., et al.
Science [Epub ahead of print]. (30th July 2015)
- Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Zhang, R., Alushin, GM., Brown, A., Nogales, E.
Cell [Epub ahead of print]. (28th July 2015)
- Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Aibara, S., Valkov, E., Lamers, MH., Dimitrova, L., Hurt, E., Stewart, M.
Acta Crystallogr F Struct Biol Commun 71(Pt 7): 876-88. (27th July 2015)
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