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The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Ten Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
The DNA in cells is constantly damaged by both internal activities of the cell and by external factors such as ionising radiation. In order to function correctly, this damage must be repaired, or if it cannot be repaired, the cell must be…
G protein-coupled receptors (GPCRs) form the largest family of membrane-protein receptors and drug targets. With over 800 different family members in humans, GPCRs regulate diverse intracellular signalling cascades in different cell types, tissues and organ systems. Whilst GPCRs sense a plethora of…
- Anne Bertolotti elected Fellow of the UK Academy of Medical Sciences
Anne Bertolotti, group leader in the LMB’s Neurobiology Division, has been elected a Fellow of […]
- Three LMB scientists elected Fellows of the Royal Society
Andrew McKenzie, John Sutherland and Roger Williams, all Group Leaders in the LMB’s PNAC Division, […]
- Modulation of sensory information processing by a neuroglobin in Caenorhabditis elegans.
Oda, S., Toyoshima, Y., de Bono, M.
Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print]. (23rd May 2017)
- Matching phenotypes to whole genomes: Lessons learned from four iterations of the personal genome project community challenges.
Cai, B., et al.
Hum. Mutat. [Epub ahead of print]. (23rd May 2017)
- Structure of a pre-catalytic spliceosome.
Plaschka, C., Lin, PC., Nagai, K.
Nature [Epub ahead of print]. (22nd May 2017)
- Chemical structure-guided design of dynapyrazoles, potent cell-permeable dynein inhibitors with a unique mode of action.
Steinman, JB., et al.
Elife 6 [Epub ahead of print]. (19th May 2017)
- Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex.
Gordon, JMB., Aibara, S., Stewart, M.
Nucleic Acids Res. 45(9): 5577-5585. (19th May 2017)
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