The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
An unexpected finding from Julian Sale’s group in the LMB’s PNAC Division has revealed that a specialised histone protein called H3.3 is needed for packaging UV-damaged DNA during replication. Use of this histone may act as a flag to help the cell find and repair the damage once replication has been completed, potentially reducing the […]
Research from the LMB’s PNAC Division has revealed a new mechanism that cells use to fight infection. Jerry Tam and other members of Leo James’s group have discovered that the protein complement C3, which covalently labels viruses and bacteria in the bloodstream, activates a potent immune response upon cell invasion. Molecular biologists chemically modify proteins […]
- LMB finalist in BIFM Awards 2014
Representatives from the LMB attended a glittering ceremony, hosted by comic and actor Hugh Dennis, […]
- Science Image Award winners announced
The winners of an LMB competition designed to inspire young children about the microscopic world […]
- 2014 Francis Crick Lecture to be given by Stephen J. Elledge
Stephen J. Elledge, Gregor Mendel Professor of Genetics, Department of Genetics, Harvard Medical School will […]
- LMB wins Safe, Successful and Sustainable S-Lab Award 2014
The new LMB building has been announced as joint winner of the 2014 S-Lab award […]
- Signalosome assembly by domains undergoing dynamic head-to-tail polymerization.
Trends Biochem. Sci. 39(10): 487-495. (16th October 2014)
- Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger.
Miller, TC., Rutherford, TJ., Birchall, K., Chugh, J., Fiedler, M., Bienz, M.
ACS Chem. Biol. [Epub ahead of print]. (16th October 2014)
- CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing.
Chan, SL., Huppertz, I., Yao, C., Weng, L., Moresco, JJ., Yates, JR., Ule, J., Manley, JL., Shi, Y.
Genes Dev. [Epub ahead of print]. (9th October 2014)
- Why do brains need tau (MAPT) ?
FEBS J. [Epub ahead of print]. (7th October 2014)
- The structural basis for mTOR function.
Baretić, D., Williams, RL.
Semin. Cell Dev. Biol. [Epub ahead of print]. (5th October 2014)
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