The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Ten Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Mitochondria are organelles within eukaryotic cells that likely evolved from an ancient bacterium that was engulfed by a primordial eukaryote. Within mitochondria, mitochondrial ribosomes (mitoribosomes) synthesise a subset of essential proteins encoded by the mitochondrial genome. Although mitoribosomes share a common ancestor…
Every minute, cells make millions of new proteins which must be transported to the correct location, folded, modified and assembled with other proteins in order to function properly. Failure at any of these maturation steps can reduce protein function and lead to…
- 2017 Milstein Lecture to be given by Thomas Südhof
Professor Thomas Südhof will give the 2017 Milstein Lecture on Thursday 9th February 2017 at […]
- LMB welcomes new group leaders: John Briggs and Julian Gough
The LMB is delighted to announce the recent arrival of two new group leaders in […]
- Structure of a spliceosome remodelled for exon ligation.
Fica, SM., Oubridge, C., Galej, WP., Wilkinson, ME., Bai, XC., Newman, AJ., Nagai, K.
Nature 542(7641): 377-380. (16th February 2017)
- Second Generation Drosophila Chemical Tags: Sensitivity, Versatility and Speed.
Sutcliffe, B., Ng, J., Auer, TO., Pasche, M., Benton, R., Jefferis, GS., Cachero, S.
Genetics [Epub ahead of print]. (16th February 2017)
- A polycystin-type transient receptor potential (Trp) channel that is activated by ATP.
Traynor, D., Kay, RR.
Biol Open 6(2): 200-209. (15th February 2017)
- TORmented macrophages spontaneously form granulomas.
Pagán, AJ., Ramakrishnan, L.
Nat. Immunol. 18(3): 252-253. (15th February 2017)
- Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme.
Li, Y., Zhou, M., Hu, Q., Bai, XC., Huang, W., Scheres, SH., Shi, Y.
Proc. Natl. Acad. Sci. U.S.A. 114(7): 1542-1547. (14th February 2017)
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