The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
We, and all animals, sense things in our surroundings and react to them, but how a sensory input reaching the brain is transformed into behaviour is still unknown for all but the most simple reflexes. To better understand this, Greg Jefferis’ group in the LMB’s Neurobiology Division in collaboration with researchers at the Janelia Research Campus have performed the first deep and comprehensive functional analysis into the innate odour processing pathway of a behaviourally complex animal,
Our genetic code is translated from DNA into proteins through an intermediate molecule: messenger RNA (mRNA). One major way in which synthesis of proteins can be regulated is through turnover of mRNA; less protein is produced from a short-lived mRNA molecule.
- Michael Rossmann 1930 – 2019
Michael Rossmann, Hanley Distinguished Professor of Biological Sciences at Purdue University and former scientific staff […]
- Menna Clatworthy receives an EFIS-IL Lecture Award
Menna Clatworthy, a Group Leader in the University of Cambridge Molecular Immunity Unit based at […]
- LMB 365 project captures life and work at the LMB
- Innovative design key to world-renowned facility’s success – a profile of the design and architecture of the LMB
- Functional and anatomical specificity in a higher olfactory centre.
Frechter, S., et al.
Elife 8 [Epub ahead of print]. (21st May 2019)
- Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body.
Dolan, MJ., et al.
Elife 8. (21st May 2019)
- The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Tang, TTL., Stowell, JAW., Hill, CH., Passmore, LA.
Nat. Struct. Mol. Biol. [Epub ahead of print]. (20th May 2019)
- Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions.
Pirovano, L., et al.
Nat Commun 10(1): 2208. (17th May 2019)
- Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors.
Zavodszky, E., Hegde, RS.
Elife 8 [Epub ahead of print]. (16th May 2019)
- Cryo-EM structures of GPCRs coupled to G, G and G.
García-Nafría, J., Tate, CG.
Mol. Cell. Endocrinol. 488: 1-13. (15th May 2019)
- Total synthesis of Escherichia coli with a recoded genome.
Fredens, J., et al.
Nature [Epub ahead of print]. (15th May 2019)
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