The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
The atomic structure of the 170 kDa membrane protein gamma-secretase, a membrane protein complex that has an important role in Alzheimer’s disease, has been solved using single-particle cryo-electron microscopy (cryo-EM) by Sjors Scheres’ group in the LMB’s Structural Studies Division. This demonstrates for the first time that high-resolution reconstruction of such small molecules can be…
New research from the LMB’s Cell Biology and Structural Studies Divisions has answered a long-standing problem in molecular biology: how does the ribosome decode the signals to stop protein synthesis? In cells, all proteins are produced by ribosomes that ‘read’ messenger RNA (mRNA) one codon, or three nucleotides, at a time. Protein translation terminates when…
- LMB wins bronze in Summer Cycle Challenge
The LMB has yet again shown how committed its staff are to cycling by coming […]
- The work of Fred Sanger – an online exhibition
A new online exhibition, sponsored by the MRC, explores the work and legacy of double […]
- Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging.
Bharat, TA., Russo, CJ., Löwe, J., Passmore, LA., Scheres, SH.
Structure 23(9): 1743-1753. (1st September 2015)
- Cooperative Dynamics of Intact AMPA and NMDA Glutamate Receptors: Similarities and Subfamily-Specific Differences.
Dutta, A., Krieger, J., Lee, JY., Garcia-Nafria, J., Greger, IH., Bahar, I.
Structure 23(9): 1692-1704. (1st September 2015)
- RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma.
Uren, PJ., et al.
Mol. Cell. Biol. 35(17): 2965-78. (1st September 2015)
- BRCA1 is required for maintenance of phospho-Chk1 and G2/M arrest during DNA crosslink repair in DT40 cells.
Draga, M., et al.
Mol. Cell. Biol. [Epub ahead of print]. (31st August 2015)
- Inflammation-induced formation of fat-associated lymphoid clusters.
Bénézech, C., et al.
Nat. Immunol. 16(8): 819-28. (29th August 2015)
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