The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
The proteasome is a protein recycling complex that plays a critical role in the smooth running of our cells. It is present in all multicellular organisms and facilitates cell renewal and the controlled death of damaged cells. Paula da Fonseca, from the LMB’s Structural Studies Division, and Edward Morris, from the Institute of Cancer Research,…
Genes in eukaryotic organisms are frequently interrupted by non-coding segments called introns. Before the protein can be produced, the entire length of each gene including the introns, is transcribed to produce precursor messenger RNA (pre-mRNA). An immense and dynamic molecular machine known as the spliceosome then removes the introns and splices the coding segments together…
- LMB CamAWiSE annual ‘What next in your career’ event
The LMB and CambridgeAWiSE recently held their 9th annual ‘What next in your career’ event […]
- Megan Davies awarded MBE in Queen’s Birthday Honours
The LMB is delighted to congratulate Megan Davies on being awarded the MBE in the […]
- Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.
da Fonseca, PC., Morris, EP.
Nat Commun 6: 7573. (2nd July 2015)
- Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.
Bharat, TA., Murshudov, GN., Sachse, C., Löwe, J.
Nature 523(7558): 106-10. (2nd July 2015)
- Spatiotemporal control of a novel synaptic organizer molecule.
Howell, K., White, JG., Hobert, O.
Nature 523(7558): 83-7. (2nd July 2015)
- The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
Nguyen, TH., Galej, WP., Bai, XC., Savva, CG., Newman, AJ., Scheres, SH., Nagai, K.
Nature 523(7558): 47-52. (2nd July 2015)
- Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog.
Rogerson, DT., et al.
Nat. Chem. Biol. 11(7): 496-503. (1st July 2015)
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