About us

The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.

Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.

Insight on research

Dynactin complex structure revealed by electron cryo-microscopy


Dynactin is a protein complex that activates the dynein motor protein, enabling intracellular transport. It is extremely flexible and has proved very difficult to study by conventional crystallography methods. Now for the first time, research carried out by Andrew Carter and his group in the LMB’s Structural Studies Division, has revealed the structure of this…

Unfinished proteins: how to find a needle in the haystack


A research team from the LMB’s Cell Biology division, working with colleagues from the Structural Studies division, has revealed how cells are able to find and tag for degradation the partially synthesised proteins generated when ribosomes occasionally stall. Cells make more than a hundred thousand new proteins every minute. Once in a while, one of…

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