The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Ten Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
The Wnt signalling pathway is an ancient cell communication pathway that has important roles in development and cancer. Wnt signals elicit context-dependent transcriptional responses by stabilising a cytoplasmic effector called beta-catenin. This controls the embryonic development of tissues and organs in all…
DNA in the nucleus is arranged into nucleosomes to produce an 11nm fibre which then intricately folds into high order assemblies. This nuclear organisation – the 3D arrangement of the genome within the nucleus – is critically linked to nuclear processes. Previously…
- Max Perutz Lecture to be given by Caroline Dean
Caroline Dean will give the 2016 Max Perutz Lecture on Thursday 27th April 2017 at […]
- Christopher Russo awarded the Microscopy Society of America Burton Medal
Chris Russo, Independent Investigator Scientist in the LMB’s Structural Studies Division, has been awarded the […]
- A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization.
Xu, J., et al.
Nat Chem 9(4): 303-309. (21st April 2017)
- Structural biology: A receptor that might block itself.
Nature 544(7650): 307-308. (20th April 2017)
- Mini-G proteins: Novel tools for studying GPCRs in their active conformation.
Nehmé, R., et al.
PLoS ONE 12(4): e0175642. (20th April 2017)
- Activity-Based Probes for HECT E3 ubiquitin ligases.
Byrne, R., Mund, T., Licchesi, J.
Chembiochem [Epub ahead of print]. (20th April 2017)
- Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells.
Bruemmer, KJ., et al.
J. Am. Chem. Soc. 139(15): 5338-5350. (19th April 2017)
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