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The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Eleven Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Internal transport between different cellular compartments is a complicated process requiring formation of transport carriers, and sorting the right cargo into those carriers, for delivery to the correct part of the cell. Retromer is a protein complex that forms transport carriers departing…
Cells need to respond quickly when they encounter stress conditions in order to avoid consequences such as cell death. New research from Madan Babu’s group in the LMB’s Structural Studies Division has identified a mechanism by which cells can enhance the expression…
- Wanda Kukulski awarded the Royal Microscopical Society’s Alan Agar Medal
Wanda Kukulski, group leader in the LMB’s Cell Biology Division, has been awarded the Royal […]
- Fred Sanger at the LMB: From DNA sequencing to the advent of genomics
Celebrating the work of Fred Sanger on the centenary of his birth. One modest, reserved […]
- Fabrice Gorrec has been shortlisted for the Researcher of the Year category at the Cambridge Independent Science and Technology Awards 2018
- Nature reviews Venki Ramakrishnan’s new book
- Planar cell polarity: the prickle gene acts independently on both the Ds/Ft and the Stan/Fz systems.
Casal, J., Ibáñez-Jiménez, B., Lawrence, PA.
Development 145(18). (17th September 2018)
- The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex.
Sammak, S., Allen, MD., Hamdani, N., Bycroft, M., Zinzalla, G.
FEBS J. [Epub ahead of print]. (17th September 2018)
- Structure of the membrane-assembled retromer coat determined by cryo-electron tomography.
Kovtun, O., et al.
Nature [Epub ahead of print]. (17th September 2018)
- Anesthetic considerations for scoliosis surgery in a patient with recessive severe/lethal form of osteogenesis imperfecta.
Chin, JWE., Stuart, GM.
Paediatr Anaesth 28(9): 817-818. (16th September 2018)
- High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation.
Mattei, S., Tan, A., Glass, B., Müller, B., Kräusslich, HG., Briggs, JAG.
Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print]. (14th September 2018)
- TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination.
Bottermann, M., et al.
Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print]. (12th September 2018)
- Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB.
Kureisaite-Ciziene, D., et al.
MBio 9(5). (11th September 2018)
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