The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
Effective immunity to infections requires the development of a diverse repertoire of antibodies. Antibody diversity is created through a process known as somatic hypermutation, which is the programmed mutation of specific sequences of DNA in the antibody genes. The introduction of mutations results in the production of antibodies that recognise and bind to different antigens,…
Target of Rapamycin (TOR) is a protein kinase that is essential in maintaining cellular homeostasis. In mammalian cells the enzyme occurs as two large protein complexes and one of these, mTORC1, controls growth of cells by integrating signals from growth factors and the nutritional state of cells. Many tumours in humans are associated with inappropriate…
- Max Perutz Lecture to be given by Ron Vale
Ron Vale will give the delayed Max Perutz Lecture 2015 on Thursday 2nd June 2016 […]
- Richard Henderson wins Royal Society’s prestigious Copley Medal
Richard Henderson from the LMB’s Structural Studies Division has been awarded the Royal Society’s most […]
- Matrin3: connecting gene expression with the nuclear matrix.
Coelho, MB., Attig, J., Ule, J., Smith, CW.
Wiley Interdiscip Rev RNA 7(3): 303-15. (26th May 2016)
- Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.
Romanello, M., Schiavone, D., Frey, A., Sale, JE.
EMBO J. [Epub ahead of print]. (23rd May 2016)
- Shwachman-Bodian-Diamond syndrome (SBDS) protein deficiency impairs translation re-initiation from C/EBPα and C/EBPβ mRNAs.
In, K., Zaini, MA., Müller, C., Warren, AJ., von Lindern, M., Calkhoven, CF.
Nucleic Acids Res. 44(9): 4134-46. (19th May 2016)
- PACRG, a Protein Linked to Ciliary Motility, Mediates Cellular Signaling.
Loucks, CM., et al.
Mol. Biol. Cell [Epub ahead of print]. (18th May 2016)
- TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens.
Hiraishi, Y., et al.
Allergol Int [Epub ahead of print]. (18th May 2016)
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