The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Ten Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Dyneins are a family of motor proteins that move along microtubules to transport various important cargos, including proteins and RNAs, to different parts of the cell and are crucial to correct cell function. Gradually, the structure of various components of dynein have…
The DNA in cells is constantly damaged by both internal activities of the cell and by external factors such as ionising radiation. In order to function correctly, this damage must be repaired, or if it cannot be repaired, the cell must be…
- LMB welcomes over 2000 visitors to a fun-packed Open Day
On Saturday 17th June the LMB held a spectacular Open Day as part of the […]
- Sjors Scheres elected to EMBO membership
Sjors Scheres, a Group Leader in the LMB’s Structural Studies Division, has been elected as […]
- MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.
Li, X., et al.
Nat Commun 8: 15986. (28th June 2017)
- A Novel Tool to Measure Extracellular Glutamate in the Zebrafish Nervous System In Vivo.
MacDonald, RB., Kashikar, ND., Lagnado, L., Harris, WA.
Zebrafish 14(3): 284-286. (27th June 2017)
- Structural studies of viperin, an antiviral radical SAM enzyme.
Fenwick, MK., Li, Y., Cresswell, P., Modis, Y., Ealick, SE.
Proc. Natl. Acad. Sci. U.S.A. 114(26): 6806-6811. (27th June 2017)
- Reversible swelling of sbmv is associated with reversible disordering.
Li, J., Fricks, C., Caspar, DLD., Rayment, I.
J. Struct. Biol. [Epub ahead of print]. (21st June 2017)
- Friction Mediates Scission of Tubular Membranes Scaffolded by BAR Proteins.
Simunovic, M., et al.
Cell [Epub ahead of print]. (21st June 2017)
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