The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
Every year hundreds of millions of people worldwide are affected by Malaria and nearly half a million die from the disease. More than two thirds of those dying are children under five. The disease is caused by parasites passed to humans through the bites of infected mosquitoes, with Plasmodium falciparum being the parasite responsible for…
Cell-to-cell variability in gene expression level (noise) has emerged as one of the fundamental concepts in genetics. Non-genetic, cell-to-cell variation in the abundance of a gene product can generate a diversity of behaviour in genetically identical population of cells. This phenomenon is pervasive and prevalent in development (e.g. stem cells) and disease (e.g. cancer). Genome-scale…
- 2016 Francis Crick Lecture to be given by Adrian Bird
Adrian Bird will give the 2016 Francis Crick Lecture on Tuesday 16th February 2016 at […]
- LMB raises over £1300 for Cancer Research UK
The LMB’s annual charity Christmas raffle took place in December 2015. Staff at the LMB […]
- Structure- and function-based design of Plasmodium-selective proteasome inhibitors.
Li, H., et al.
Nature 530(7589): 233-6. (11th February 2016)
- Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.
Jarrett, R., et al.
Sci Transl Med 8(325): 325ra18. (10th February 2016)
- Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.
Zimmer, J., et al.
Mol. Cell 61(3): 449-60. (4th February 2016)
- Genetic code expansion in stable cell lines enables encoded chromatin modification.
Elsässer, SJ., Ernst, RJ., Walker, OS., Chin, JW.
Nat. Methods 13(2): 158-64. (4th February 2016)
- Co-expression of truncated and full-length tau induces severe neurotoxicity.
Ozcelik, S., et al.
Mol. Psychiatry [Epub ahead of print]. (2nd February 2016)
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