The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
In order to function properly, many of the cell’s proteins need to be segregated to membrane-bound organelles and assembled into multi-protein complexes. Newly made proteins that fail to be localised or assembled properly must be promptly recognised by the cell and destroyed. These pathways of protein quality control are important because the accumulation of aberrant…
Effective immunity to infections requires the development of a diverse repertoire of antibodies. Antibody diversity is created through a process known as somatic hypermutation, which is the programmed mutation of specific sequences of DNA in the antibody genes. The introduction of mutations results in the production of antibodies that recognise and bind to different antigens,…
- Max Perutz Lecture to be given by Ron Vale
Ron Vale will give the delayed Max Perutz Lecture 2015 on Thursday 2nd June 2016 […]
- Richard Henderson wins Royal Society’s prestigious Copley Medal
Richard Henderson from the LMB’s Structural Studies Division has been awarded the Royal Society’s most […]
- Clathrin modulates vesicle scission, but not invagination shape, in yeast endocytosis.
Kukulski, W., Picco, A., Specht, T., Briggs, JA., Kaksonen, M.
Elife 5 [Epub ahead of print]. (24th June 2016)
- Anatomical characterization of the cannabinoid cb1 receptor in cell type-specific mutant mouse rescue models.
Gutiérrez-Rodríguez, A., et al.
J. Comp. Neurol. [Epub ahead of print]. (23rd June 2016)
- Structural and calorimetric studies demonstrate that the Hepatocyte Nuclear Factor1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence.
Wiedmann, MM., Aibara, S., Spring, DR., Stewart, M., Brenton, JD.
J. Struct. Biol. [Epub ahead of print]. (21st June 2016)
- Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs.
Bauer, MR., et al.
ACS Chem. Biol. [Epub ahead of print]. (21st June 2016)
- Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.
Itakura, E., Zavodszky, E., Shao, S., Wohlever, ML., Keenan, RJ., Hegde, RS.
Mol. Cell [Epub ahead of print]. (21st June 2016)
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