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The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Ten Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Cell growth requires the synthesis of molecules, such as nucleotides to make DNA and amino acids to make proteins. One essential building block of these is the one carbon unit. This is produced by the one carbon (1C) cycle, which requires the…
Amino acids are the building blocks of proteins. Just twenty different amino acids are strung together in different orders – like beads – to build all the proteins in living organisms. When a single type of amino acid is found consecutively within…
- The UK’s dementia research landscape: LMB is a piece of the jigsaw
The UK’s dementia research landscape is an impressive and complex jigsaw – made up of […]
- Richard Henderson and Nigel Unwin awarded Gjønnes Medal in Electron Crystallography
The International Union of Crystallography (IUCr) Gjønnes Medal in Electron Crystallography has been awarded to […]
- Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.
Pirali, T., et al.
ChemMedChem 12(18): 1542-1554. (21st September 2017)
- Measuring the effects of particle orientation to improve the efficiency of electron cryomicroscopy.
Naydenova, K., Russo, CJ.
Nat Commun 8(1): 629. (20th September 2017)
- Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis.
Trabanelli, S., et al.
Nat Commun 8(1): 593. (19th September 2017)
- Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages.
Cambier, CJ., O'Leary, SM., O'Sullivan, MP., Keane, J., Ramakrishnan, L.
Immunity 47(3): 552-565.e4. (19th September 2017)
- Using the force to find the peptides you're looking for.
Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print]. (18th September 2017)
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