The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Ten Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
The spliceosome is a molecular machine, which together with RNA polymerases and ribosomes plays a critical role in basic gene expression. Research by Kiyoshi Nagai’s group in the LMB’s Structural Studies Division, has previously revealed the structure of the spliceosome in a…
Macropinocytosis, the cellular uptake of fluids from the environment, is employed by a variety of cells and requires the formation of a cup-shaped structure that protrudes from the cell’s surface and captures gulps of medium. Polymerisation of actin under the plasma membrane…
- Phoebe Dent completes her apprenticeship in the LMB’s HR team
Phoebe Dent joined the LMB at the age of 16 as an HR Assistant Apprentice […]
- Manu Hegde receives Feldberg Foundation Prize
Manu Hegde, Group Leader in the LMB’s Cell Biology Division, has been awarded the 2018 […]
- Mucosal Type 2 Innate Lymphoid Cells are a Key Component of the Allergic Response to Aeroallergen.
Dhariwal, J., et al.
Am. J. Respir. Crit. Care Med. [Epub ahead of print]. (13th January 2017)
- Structure of a spliceosome remodelled for exon ligation.
Fica, SM., Oubridge, C., Galej, WP., Wilkinson, ME., Bai, XC., Newman, AJ., Nagai, K.
Nature [Epub ahead of print]. (11th January 2017)
- Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging.
Soreq, L., et al.
Cell Rep 18(2): 557-570. (10th January 2017)
- Self-correcting mismatches during high-fidelity DNA replication.
Fernandez-Leiro, R., Conrad, J., Yang, JC., Freund, SM., Scheres, SH., Lamers, MH.
Nat. Struct. Mol. Biol. [Epub ahead of print]. (9th January 2017)
- Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.
Wiedmann, MM., et al.
Angew. Chem. Int. Ed. Engl. 56(2): 524-529. (9th January 2017)
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