The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
In their latest research on the DNA replication machinery from Mycobacterium tuberculosis, Ulla Lang in Meindert Lamers’ group in the LMB’s Structural Studies Division and collaborators at the Harvard School of Public Health in Boston, have revealed the existence of a novel exonuclease that proofreads new DNA as it is synthesised. This newly discovered proofreader…
The existence of an endogenous daily clock in humans is well known: it is what drives the 24-hour sleep/wake rhythm to match the daily cycle of night and day. That this biological circadian rhythm occurs in individual cells, and that they continue to ‘tick’ in a petri dish is now well-accepted scientifically, but the mechanism…
- LMB welcomes two new group leaders: Rebecca Taylor and Wanda Kukulski
The LMB is delighted to announce the recent arrival of two new group leaders: Rebecca […]
- Golden grids for electron microscopy licensed by Quantifoil
New specimen support grids for electron microscopy, made of pure gold and designed by Lori […]
- Hands-on activities by LMB scientists at the Cambridge Science Festival
The opening weekend of the 2015 Cambridge Science Festival was a huge success, with thousands […]
- 30 Bird and public works to be LMB Artists-in-Residence
The LMB has appointed 30 Bird and public works as LMB Artists-in-Residence starting in April […]
- Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne.
Machida, T., Lang, K., Xue, L., Chin, JW., Winssinger, N.
Bioconjug. Chem. [Epub ahead of print]. (24th April 2015)
- A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.
Cook, PC., et al.
Nat Commun 6: 6920. (24th April 2015)
- Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization.
Madrzak, J., Fiedler, M., Johnson, CM., Ewan, R., Knebel, A., Bienz, M., Chin, JW.
Nat Commun 6: 6718. (24th April 2015)
- The RNA-binding protein HuR is essential for the B cell antibody response.
Diaz-Muñoz, MD., et al.
Nat. Immunol. 16(4): 415-25. (23rd April 2015)
- DNA structure and function.
Travers, A., Muskhelishvili, G.
FEBS J. [Epub ahead of print]. (22nd April 2015)
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