About us

The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.

Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.

Insight on research

BOLT, a fast and selective way to regulate protein function in live cells

Chin_Figure-BOLT

Small molecules are often used to regulate the functions of proteins and provide many drugs and tools for understanding biological pathways. However, selectively controlling a specific target protein within living cells is a major challenge. Jason Chin’s group from the LMB’s PNAC Division have created a new technique called BOLT that can selectively regulate specific…

Freeze-thaw cycles turn life’s simple building blocks into functional macromolecules

Holliger_freeze_thaw_news

There is compelling evidence that in the distant past, our single-celled ancestors used RNA, a chemical cousin of DNA, for both genetic information storage and metabolism. This primordial “RNA world” would have needed an RNA enzyme able to replicate itself and other primordial “RNA genes”. However, it is not known how such a complex function…

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