About us

The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.

Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.

Insight on research

Unexpected role of Histone H3.3 in replication of damaged DNA


An unexpected finding from Julian Sale’s group in the LMB’s PNAC Division has revealed that a specialised histone protein called H3.3 is needed for packaging UV-damaged DNA during replication. Use of this histone may act as a flag to help the cell find and repair the damage once replication has been completed, potentially reducing the []

New mechanism of antiviral immunity discovered

Leo James - New Mechanism of Antiviral Immunity

Research from the LMB’s PNAC Division has revealed a new mechanism that cells use to fight infection. Jerry Tam and other members of Leo James’s group have discovered that the protein complement C3, which covalently labels viruses and bacteria in the bloodstream, activates a potent immune response upon cell invasion. Molecular biologists chemically modify proteins []

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