The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Ten Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
The Wnt signalling pathway is an ancient cell communication pathway that has important roles in development and cancer. Wnt signals elicit context-dependent transcriptional responses by stabilising a cytoplasmic effector called beta-catenin. This controls the embryonic development of tissues and organs in all…
DNA in the nucleus is arranged into nucleosomes to produce an 11nm fibre which then intricately folds into high order assemblies. This nuclear organisation – the 3D arrangement of the genome within the nucleus – is critically linked to nuclear processes. Previously…
- Hundreds of children and adults enjoy the LMB’s ‘See Your Cells’ activity at the Cambridge Science Festival
The first weekend of the 2017 Cambridge Science Festival saw over 3000 visitors attend the […]
- LMB PhD student takes her research to Parliament
Cara Ellison, a PhD student in Felix Randow’s group in the LMB’s PNAC Division, attended […]
- Using hiCLIP to identify RNA duplexes that interact with a specific RNA-binding protein.
Sugimoto, Y., Chakrabarti, AM., Luscombe, NM., Ule, J.
Nat Protoc 12(3): 611-637. (23rd March 2017)
- SnapShot: Subcellular mRNA Localization.
Mofatteh, M., Bullock, SL.
Cell 169(1): 178-178.e1. (23rd March 2017)
- Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
Brancaccio, M., Patton, AP., Chesham, JE., Maywood, ES., Hastings, MH.
Neuron 93(6): 1420-1435.e5. (22nd March 2017)
- Simultaneous quantification of protein order and disorder.
Sormanni, P., et al.
Nat. Chem. Biol. 13(4): 339-342. (22nd March 2017)
- A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS.
Bao, L., Al-Assar, O., Drynan, LF., Arends, MJ., Tyers, P., Barker, RA., Rabbitts, TH.
Sci Rep 7: 44899. (21st March 2017)
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