The LMB is responsible for many pioneering techniques, such as methods for determining the three-dimensional structures of proteins and other macromolecules, the sequencing of DNA and the development of monoclonal antibodies.
Our scientists tackle difficult, long-term research problems. At the same time they are encouraged to exploit their discoveries – through patents, licensing and business start-ups – helping to advance medical research and improve the UK’s economic competitiveness.
An unexpected finding from Julian Sale’s group in the LMB’s PNAC Division has revealed that a specialised histone protein called H3.3 is needed for packaging UV-damaged DNA during replication. Use of this histone may act as a flag to help the cell find and repair the damage once replication has been completed, potentially reducing the […]
Research from the LMB’s PNAC Division has revealed a new mechanism that cells use to fight infection. Jerry Tam and other members of Leo James’s group have discovered that the protein complement C3, which covalently labels viruses and bacteria in the bloodstream, activates a potent immune response upon cell invasion. Molecular biologists chemically modify proteins […]
- 2014 Francis Crick Lecture to be given by Stephen J. Elledge
Stephen J. Elledge, Gregor Mendel Professor of Genetics, Department of Genetics, Harvard Medical School will […]
- LMB wins Safe, Successful and Sustainable S-Lab Award 2014
The new LMB building has been announced as joint winner of the 2014 S-Lab award […]
- Melina Schuh and M. Madan Babu awarded Lister Research Prizes
The prestigious Lister Institute Research Prize is awarded annually to three or four young researchers […]
- Protein Synthesis Technology developed at the LMB licenced for use in drug discovery
A method for linking proteins together with specific chemical bonds, developed in the LMB’s PNAC […]
- Maternal Aldehyde Elimination during Pregnancy Preserves the Fetal Genome.
Oberbeck, N., Langevin, F., King, G., de Wind, N., Crossan, GP., Patel, KJ.
Mol. Cell 55(6): 807-17. (18th September 2014)
- Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
Blanco, S., et al.
EMBO J. 33(18): 2020-39. (17th September 2014)
- Clathrin-independent pathways do not contribute significantly to endocytic flux.
Bitsikas, V., Corrêa, IR., Nichols, BJ.
Elife 3 [Epub ahead of print]. (17th September 2014)
- Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells.
Bidgood, SR., Tam, JC., McEwan, WA., Mallery, DL., James, LC.
Proc. Natl. Acad. Sci. U.S.A. 111(37): 13463-8. (16th September 2014)
- Ultrafast tissue staining with chemical tags.
Kohl, J., et al.
Proc. Natl. Acad. Sci. U.S.A. 111(36): E3805-14. (9th September 2014)
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