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The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
The human genome encodes thousands of proteins that are embedded in the membranes of all cells. These membrane proteins have numerous functions ranging from ion transport, to cell communication, to sensing odours, and others. In order to carry out these functions, they…
A collaborative team from the LMB’s Cell Biology and Structural Studies Divisions has identified a cellular factor that detects ribosome collisions. The ribosome is the molecular machine responsible for reading the genetic code to produce proteins, a process known as translation. Such…
- LMB raises £344.35 at Macmillan Coffee Morning
For the fourth year in a row, the LMB’s HR team, supported by colleagues throughout […]
- An engaging month for LMB researchers
Over 30 LMB researchers have taken part in a range of activities as part of […]
- Decades of discovery set to revolutionise healthcare
- The Resolution Revolutionary – Richard Henderson
- Recruiting more proteins to the RNA world.
Scott, WG., Nagai, K.
Science 362(6415): 644-645. (9th November 2018)
- New tools for automated high-resolution cryo-EM structure determination in RELION-3.
Zivanov, J., Nakane, T., Forsberg, BO., Kimanius, D., Hagen, WJ., Lindahl, E., Scheres, SH.
Elife 7 [Epub ahead of print]. (9th November 2018)
- Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila.
Dolan, MJ., et al.
Neuron 100(3): 651-668.e8. (7th November 2018)
- Global and Multiplexed Dendritic Computations under In Vivo-like Conditions.
Ujfalussy, BB., Makara, JK., Lengyel, M., Branco, T.
Neuron 100(3): 579-592.e5. (7th November 2018)
- InterPro in 2019: improving coverage, classification and access to protein sequence annotations.
Mitchell, AL., et al.
Nucleic Acids Res. [Epub ahead of print]. (6th November 2018)
- pH-Driven RNA Strand Separation under Prebiotically Plausible Conditions.
Mariani, A., Bonfio, C., Johnson, CM., Sutherland, JD.
Biochemistry [Epub ahead of print]. (5th November 2018)
- Dynamic protein-RNA interactions in mediating splicing catalysis.
Chung, CS., Tseng, CK., Lai, YH., Wang, HF., Newman, AJ., Cheng, SC.
Nucleic Acids Res. [Epub ahead of print]. (5th November 2018)
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