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The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Ten Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
All the cells in our body contain thousands of proteins, molecular machines which carry out almost all biological processes that are essential for life. Many diseases, such as cancer and neurodegeneration, are caused when these protein machines go wrong. Thus it has…
The spliceosome is a molecular machine that plays an important role in gene expression. It cuts non-coding sequences (introns) out of messenger RNA (mRNA) precursors, and stitches together the useful coding sequences (exons). The spliceosome performs this in two steps. First, the…
- LMB cycles to first place in September Challenge
LMB cyclists have ridden to the top of the leader board in this year’s Cycle […]
- Macmillan coffee morning at LMB raises £375
The LMB’s HR team, supported by colleagues at the LMB, once again took part in […]
- Immature HIV-1 lattice assembly dynamics are regulated by scaffolding from nucleic acid and the plasma membrane.
Pak, AJ., et al.
Proc. Natl. Acad. Sci. U.S.A. 114(47): E10056-E10065. (21st November 2017)
- Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation.
Davey, GE., et al.
Nat Commun 8(1): 1575. (17th November 2017)
- Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Wilkinson, ME., Fica, SM., Galej, WP., Norman, CM., Newman, AJ., Nagai, K.
Science [Epub ahead of print]. (16th November 2017)
- Structure and assembly of the Ebola virus nucleocapsid.
Wan, W., Kolesnikova, L., Clarke, M., Koehler, A., Noda, T., Becker, S., Briggs, JAG.
Nature 551(7680): 394-397. (16th November 2017)
- Multiprotein complexes governing Wnt signal transduction.
Gammons, M., Bienz, M.
Curr. Opin. Cell Biol. 51: 42-49 [Epub ahead of print]. (15th November 2017)
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