The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Our daily cycle of sleep and wakefulness – our circadian rhythm – is controlled by a central master clock in our brains: the suprachiasmatic nucleus (SCN). Previously, Michael Hastings’ group in the LMB’s Neurobiology Division had demonstrated that astrocytes were not merely the supporting cells that they had been thought to be,
Practically all brain functions are controlled through a finely tuned balance of neuronal excitation and inhibition. The main inhibitory neurotransmitter in vertebrates is gamma-aminobutyric acid (GABA). GABA signals through two types of cell surface receptors: GABAA and GABAB,
- LMB launches 365 Image Diary
Throughout 2019 we will be posting an image a day on the LMB’s website and […]
- LMB raises over £1300 for Prostate Cancer UK
LMB staff have raised over £1300 for Prostate Cancer UK at the annual charity Christmas […]
- Multiple LMB scientists and alumni feature in a list of the top ten neuroscience breakthroughs of 2018
- Jan Löwe talks with the Cambridge Independent about his group’s research and development of the Cambridge Biomedical Campus
- CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.
Mohiuddin, M., Rahman, MM., Sale, JE., Pearson, CE.
Nucleic Acids Res. [Epub ahead of print]. (18th January 2019)
- The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.
Volkmar, N., et al.
J. Cell. Sci. 132(2). (16th January 2019)
- Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.
Huguenin-Dezot, N., et al.
Nature 565(7737): 112-117. (12th January 2019)
- Cell-autonomous clock of astrocytes drives circadian behavior in mammals.
Brancaccio, M., Edwards, MD., Patton, AP., Smyllie, NJ., Chesham, JE., Maywood, ES., Hastings, MH.
Science 363(6423): 187-192. (11th January 2019)
- Akt and SGK protein kinases are required for efficient feeding by macropinocytosis.
Williams, TD., Peak-Chew, SY., Paschke, P., Kay, RR.
J. Cell. Sci. [Epub ahead of print]. (7th January 2019)
- An Electric Take on Neural Fate and Cortical Development.
Dev. Cell 48(1): 1-2. (7th January 2019)
- Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS).
Queiroz, RML., et al.
Nat. Biotechnol. [Epub ahead of print]. (3rd January 2019)
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