The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Eleven Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
All the cells in our body contain thousands of proteins, molecular machines which carry out almost all biological processes that are essential for life. Many diseases, such as cancer and neurodegeneration, are caused when these protein machines go wrong. Thus it has…
The spliceosome is a molecular machine that plays an important role in gene expression. It cuts non-coding sequences (introns) out of messenger RNA (mRNA) precursors, and stitches together the useful coding sequences (exons). The spliceosome performs this in two steps. First, the…
- LMB bake sale raises funds for ACT Breast Cancer Appeal
A team of 14 LMB volunteers have raised over £350 for the Addenbrooke’s Charitable Trust […]
- New body clock display at the Science Museum
John O’Neill, group leader in the LMB’s Cell Biology Division, has helped develop a new […]
- Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing.
Williams, RL., Anandapadamanaban, M.
Biochemistry 56(49): 6411-6412. (12th December 2017)
- UV-light-driven prebiotic synthesis of iron-sulfur clusters.
Bonfio, C., et al.
Nat Chem 9(12): 1229-1234. (10th December 2017)
- Parkinson's disease - the story of an eponym.
Goedert, M., Compston, A.
Nat Rev Neurol [Epub ahead of print]. (8th December 2017)
- Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
Lehmann, LC., et al.
Mol. Cell 68(5): 847-859.e7. (7th December 2017)
- Structure of PINK1 in complex with its substrate ubiquitin.
Schubert, AF., et al.
Nature 552(7683): 51-56. (7th December 2017)
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