Applications for the 2026 LMB PhD places are now open. Deadline is 2 December 2025.
About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
Transplant of human chromosomes marks first step in genome synthesis project

Researchers in the LMB’s PNAC Division detail a new pipeline to implant human chromosomes into mouse cells and back again without genomic damage, marking an important step towards the overall goal of synthesising human genomes.
How is the integrated stress response terminated?

Anne Bertolotti’s group in the LMB’s Neurobiology Division has resolved a longstanding question about the termination of the ISR, a signalling pathway which is crucial for cellular homeostasis.
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Latest News
EMBO selects Ana Tufegdžić Vidaković to join Young Investigator ProgrammeAna Tufegdžić Vidaković, Group Leader in the LMB’s PNAC Division, joins the global community of early-career researchers, with training, mentorship and networking opportunities from EMBO. […]
Martin Kyte (1958 – 2025)The LMB is deeply saddened to share that Martin Kyte, Senior Design Engineer in the Electronics Workshop, died suddenly in early November 2025. […]
Latest Publications
- Adjusting PSC culture for neural organoid generation.
Sutcliffe, MA., Jensen, P., Tan, J., Morris, CAJ., Fazakerley, DJ., Larsen, MR., Lancaster, MA.
Stem Cell Reports : 102724 [Epub ahead of print]. (4th December 2025) - High-fidelity human chromosome transfer and elimination.
Petris, G., et al.
Science 390(6777): 1038-1043. (4th December 2025) - Author Correction: Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.
Sanchez-Garcia, MA., et al.
Nat Immunol [Epub ahead of print]. (1st December 2025) - The advent of confocal laser scanning microscopy in biological research.
Munro, S.
Nat Rev Mol Cell Biol 26(12): 906. (30th November 2025) - Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.
Sanchez-Garcia, MA., et al.
Nat Immunol 26(11): 1903-1915. (28th November 2025) - 'Mini analysis' misrepresents changes in synaptic properties due to incomplete event detection.
Greger, IH., Watson, JF.
J Physiol 603(22): 7189-7205. (27th November 2025) - The SMC Hinge is a Selective Gate for Obstacle Bypass.
Liu, HW., Roisné-Hamelin, F., Taschner, M., Collier, J., Srinivasan, M., Gruber, S.
Nat Commun 16(1): 10457. (25th November 2025)
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