The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
While infected with SARS-CoV-2, our immune systems generate antibodies against both Spike (S) and Nucleoprotein (N). However, standard tests only show neutralisation for S-antibodies. Leo James’ group has developed a new assay that measures anti-viral activity of N-antibodies.
Although the cytoskeleton is known to play an important role in determining cell, and therefore organ, shape, how components of the cytoskeleton are reorganised during tube formation is unclear. Katja Röper’s group has identified a mechanism behind this.
- The LMB welcomes Tanmay Bharat as a new Group Leader
Tanmay Bharat is returning to the LMB, this time as a Group Leader in the Structural Studies Division, where he will continue his research into cell surfaces of prokaryotes. […]
- LMB’s new exhibition room is officially open
The LMB’s new exhibition room is officially open and is showcasing our inaugural exhibition ‘Setting the stage: development of sample holders for electron cryomicroscopy’ […]
- Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice.
Salzer, R., et al.
FEBS Lett [Epub ahead of print]. (31st July 2021)
- A functional assay for serum detection of antibodies against SARS-CoV-2 nucleoprotein.
Albecka, A., et al.
EMBO J : e108588 [Epub ahead of print]. (29th July 2021)
- The long and winding road of development: a coordinated song of transcription factors.
Makhlouf, A., N Shahbazi, M.
Nat Methods [Epub ahead of print]. (26th July 2021)
- Automatic detection of synaptic partners in a whole-brain Drosophila electron microscopy data set.
Buhmann, J., et al.
Nat Methods 18(7): 771-774. (24th July 2021)
- Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3.
Carabias, A., et al.
Nat Commun 12(1): 4476. (22nd July 2021)
- Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Yu, J., et al.
Nature [Epub ahead of print]. (21st July 2021)
- Interstrand Aminoacyl Transfer in a tRNA Acceptor Stem-Overhang Mimic.
Wu, LF., Su, M., Liu, Z., Bjork, SJ., Sutherland, JD.
J Am Chem Soc [Epub ahead of print]. (20th July 2021)
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