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The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
New insights into the architecture of organelle contact sites, and the sites’ roles in cellular lipid fluxes
Correlative microscopy, in situ imaging of protein organisation and yeast genetics refine our understanding of ER-plasma membrane contact sites
Translating ribosomes display a beacon that is exploited for selective mRNA degradation
- LMB cyclists ride high in the saddle
Once again, LMB’s cycling staff took the top spot in Cambridgeshire, and placed second in […]
- Three LMB scientists selected as EMBO Young Investigators
The science behind membrane architecture, chromosome replication and cerebral organoids finds EMBO recognition Wanda Kukulski, Madeline […]
- Cambridge Independent features the future of LMB’s Nobel-winning technology
- Nature’s 150th anniversary issue celebrates Georges Köhler, Cesar Milstein and Greg Winter’s pioneering role in the rise of monoclonal antibodies
- Genome3D: integrating a collaborative data pipeline to expand the depth and breadth of consensus protein structure annotation.
Sillitoe, I., et al.
Nucleic Acids Res. [Epub ahead of print]. (16th November 2019)
- Current Developments in Coot for Macromolecular Model Building of Electron Cryo-microscopy and Crystallographic Data.
Casañal, A., Lohkamp, B., Emsley, P.
Protein Sci. [Epub ahead of print]. (15th November 2019)
- Molecular mechanism of azithromycin resistance among typhoidal Salmonella stains in Bangladesh identified through passive pediatric surveillance.
Hooda, Y., et al.
PLoS Negl Trop Dis 13(11): e0007868 [Epub ahead of print]. (15th November 2019)
- TTC5 mediates autoregulation of tubulin via mRNA degradation.
Lin, Z., Gasic, I., Chandrasekaran, V., Peters, N., Shao, S., Mitchison, TJ., Hegde, RS.
Science [Epub ahead of print]. (14th November 2019)
- Design and structural characterisation of olfactomedin-1 variants as tools for functional studies.
Pronker, MF., van den Hoek, H., Janssen, BJC.
BMC Mol Cell Biol 20(1): 50. (14th November 2019)
- The SCOP database in 2020: expanded classification of representative family and superfamily domains of known protein structures.
Andreeva, A., Kulesha, E., Gough, J., Murzin, AG.
Nucleic Acids Res. [Epub ahead of print]. (14th November 2019)
- A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila.
Sayin, S., et al.
Neuron 104(3): 544-558.e6. (6th November 2019)
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