The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repeated blows to the head, particularly in relation to contact sports, such as American football and boxing. Understanding of the disease is limited and there is no available treatment. Definitive diagnosis currently depends on examination of the brain after death.
Cerebral organoids, also sometimes called mini-brains or brain organoids, have become an important and useful tool in understanding human brain development and disease. They have the potential to model brain functions, such as information transfer between neurons, but restrictions in their growth have so far limited this.
- Benjamin Falcon receives the 2019 Alzheimer’s Research UK Rising Star Award
Benjamin Falcon, a postdoctoral researcher in Michel Goedert’s group in the LMB’s Neurobiology Division, has […]
- Lori Passmore: polyA tails and parenthood
On International Women’s Day, the LMB releases the first in a series of group leader […]
- Tau filaments from chronic traumatic encephalopathy have distinct structure
- ‘Mini-brains on the move’ that can contract muscle
- Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex.
Hill, CH., et al.
Mol. Cell 73(6): 1217-1231.e11. (21st March 2019)
- Casein Kinase 1 Underlies Temperature Compensation of Circadian Rhythms in Human Red Blood Cells.
Beale, AD., et al.
J. Biol. Rhythms : 748730419836370 [Epub ahead of print]. (21st March 2019)
- Pulmonary group 2 innate lymphoid cells: surprises and challenges.
Starkey, MR., McKenzie, AN., Belz, GT., Hansbro, PM.
Mucosal Immunol 12(2): 299-311. (21st March 2019)
- Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Falcon, B., et al.
Nature [Epub ahead of print]. (20th March 2019)
- Cytoskeletal Control of Antigen-Dependent T Cell Activation.
Colin-York, H., et al.
Cell Rep 26(12): 3369-3379.e5. (19th March 2019)
- Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex.
Shapson-Coe, A., Valeiras, B., Wall, C., Rada, C.
PLoS ONE 14(3): e0213553. (19th March 2019)
- Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord.
Macdonald, JA., Bronner, IF., Drynan, L., Fan, J., Curry, A., Fraser, G., Lavenir, I., Goedert, M.
Acta Neuropathol Commun 7(1): 44. (18th March 2019)
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