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About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Eleven Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
Instinctive and learned responses to smells are controlled by a single brain circuit in flies
As well as having instinctive responses to their environment, nearly all animals can learn to associate particular sights, smells, or sounds with rewards or negative consequences. It had been thought that two separate brain centres control these two different types of responses;…
The structure of retromer: a molecular machine packing cargo at the cell’s logistics hub
Internal transport between different cellular compartments is a complicated process requiring formation of transport carriers, and sorting the right cargo into those carriers, for delivery to the correct part of the cell. Retromer is a protein complex that forms transport carriers departing…
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Latest News
Children enjoy an afternoon of discussing science books and hands-on experiments with LMB postdocsA group of 17 children joined postdocs from the LMB and the Department of Biochemistry […]
Wanda Kukulski awarded the Royal Microscopical Society’s Alan Agar MedalWanda Kukulski, group leader in the LMB’s Cell Biology Division, has been awarded the Royal […]
Latest Publications
- A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation.
Baumdick, M., Gelléri, M., Uttamapinant, C., Beránek, V., Chin, JW., Bastiaens, PIH.
Nat Commun 9(1): 3847. (21st September 2018) - Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion.
Smith, KA., Löser, S., Varyani, F., Harcus, Y., McSorley, HJ., McKenzie, AN., Maizels, RM.
Elife 7 [Epub ahead of print]. (21st September 2018) - Genetically Encoded Protein Phosphorylation in Mammalian Cells.
Beránek, V., Reinkemeier, CD., Zhang, MS., Liang, AD., Kym, G., Chin, JW.
Cell Chem Biol 25(9): 1067-1074.e5. (20th September 2018) - Human Diseases from Gain-of-Function Mutations in Disordered Protein Regions.
Li, XH., Babu, MM.
Cell 175(1): 40-42. (20th September 2018) - An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans.
Chew, YL., et al.
Neuron 99(6): 1233-1246.e6. (19th September 2018) - Planar cell polarity: the prickle gene acts independently on both the Ds/Ft and the Stan/Fz systems.
Casal, J., Ibáñez-Jiménez, B., Lawrence, PA.
Development 145(18). (17th September 2018) - Structure of the membrane-assembled retromer coat determined by cryo-electron tomography.
Kovtun, O., et al.
Nature [Epub ahead of print]. (17th September 2018)
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