The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Tail of SARS-CoV-2 Spike protein is optimised to reach the cell surface causing infection to spread to neighbouring cells
Sean Munro’s group, in collaboration with Leo James’ group, have determined how the tail of the Spike protein of SARS-CoV-2 allows the virus to travel beyond the Golgi in order to reach the cell surface and direct fusion to neighbouring cells to form syncytia.
Single-cell RNA sequencing analysis of over 30,000 suprachiasmatic nucleus cells by Michael Hastings’ group in the LMB’s Neurobiology Division has identified specific cell populations and highlighted the role of Prokineticinsignalling network to the body’s circadian rhythm.
- Madeline Lancaster appointed as 2021 Vallee Scholar
Madeline Lancaster has been newly appointed a Vallee Scholar to recognise her ground-breaking in vitro studies into human brain development using brain organoids […]
- The LMB welcomes new Group Leader Matteo Allegretti
Matteo Allegretti will join the LMB’s Structural Studies Division as a new Group Leader, where he will investigate the macromolecular basis of nucleus remodelling. […]
- New structural insights into the multi-functional influenza A matrix protein 1.
Peukes, J., Xiong, X., Briggs, JAG.
FEBS Lett [Epub ahead of print]. (21st September 2021)
- Dissemination of Mycobacterium abscessus via global transmission networks.
Ruis, C., et al.
Nat Microbiol [Epub ahead of print]. (20th September 2021)
- Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen.
Crowther, JM., et al.
Biochem J 478(17): 3319-3330. (17th September 2021)
- SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation.
Bidault, G., et al.
Nat Metab [Epub ahead of print]. (16th September 2021)
- Current approaches to fate mapping and lineage tracing using image data.
Wolf, S., Wan, Y., McDole, K.
Development 148(18). (15th September 2021)
- Prebiotic Photochemical Coproduction of Purine Ribo- and Deoxyribonucleosides.
Xu, J., Green, NJ., Russell, DA., Liu, Z., Sutherland, JD.
J Am Chem Soc 143(36): 14482-14486. (15th September 2021)
- Author Correction: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.
Burrows, N., et al.
Nat Immunol [Epub ahead of print]. (14th September 2021)
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