In line with government instructions, the LMB buildings are closed since midnight, 24 March as part of our efforts to suppress the spread of COVID-19. Only essential staff and those that contribute to the fight against COVID-19 are allowed access. The buildings will remain closed for three weeks in the first instance, after which the situation will be reviewed.
All other staff are working from home and all internal and external meetings are being held via video or teleconferencing. Please use email as the preferred means of contacting members of LMB.
About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
How alcohol-derived DNA damage is fixed
Alcohol consumption can indirectly cause damage to our DNA and elevate cancer risk. KJ Patel’s group in the LMB’s PNAC Division has identified a novel repair mechanism for DNA damage created by by-products of alcohol metabolism.
How is the Fanconi Anaemia pathway activated to remove DNA lesions?
New study, led by Pablo Alcón and Shabih Shakeel in Lori Passmore’s group, in collaboration with KJ Patel in the PNAC Division, uncovers a unique molecular “clamp and pin” mechanism that activates the D2l complex, which then recruits enzymes that cut out damaged DNA
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Latest News
LMB joins the fight against COVID-19From researching the science behind the virus to providing equipment to hospitals, from volunteering as experienced scientists or for the NHS, LMB staff and students are fighting the COVID-19 pandemic. […]
Daffodils announce LMB staff’s fundraising for Marie CurieLed by Freda Chapman at the LMB, our staff raised £695 for Marie Curie, a registered charitable organisation, which provides care and support to people with terminal illnesses and their families. […]
Latest Publications
- Impact of GPCR Structures on Drug Discovery.
Congreve, M., de Graaf, C., Swain, NA., Tate, CG.
Cell 181(1): 81-91. (2nd April 2020) - Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms.
Salmon, RM., et al.
Nat Commun 11(1): 1621. (1st April 2020) - Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering.
Aalbers, FS., et al.
Elife 9 [Epub ahead of print]. (31st March 2020) - Multimodal Stimulation in a Microfluidic Device Facilitates Studies of Interneurons in Sensory Integration in C. elegans.
Cho, Y., Lee, SA., Chew, YL., Broderick, K., Schafer, WR., Lu, H.
Small 16(10): e1905852. (31st March 2020) - Author Correction: CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
Ross, NT., et al.
Nat. Chem. Biol. 16(4): 479. (31st March 2020) - OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer.
Damgaard, RB., Jolin, HE., Allison, MED., Davies, SE., Titheradge, HL., McKenzie, ANJ., Komander, D.
Cell Death Differ. [Epub ahead of print]. (30th March 2020) - Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study.
Tan, L., Wang, Q., Zhang, D., Ding, J., Huang, Q., Tang, YQ., Wang, Q., Miao, H.
Signal Transduct Target Ther 5: 33. (27th March 2020)
See more Publications