The LMB is delighted to announce that Greg Winter has been awarded a share of the 2018 Nobel Prize in Chemistry, for his work on the phage display of peptides and antibodies. More…
We are now accepting applications for our PhD programme. Apply Now!
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
A collaborative team from the LMB’s Cell Biology and Structural Studies Divisions has identified a cellular factor that detects ribosome collisions. The ribosome is the molecular machine responsible for reading the genetic code to produce proteins, a process known as translation. Such…
As well as having instinctive responses to their environment, nearly all animals can learn to associate particular sights, smells, or sounds with rewards or negative consequences. It had been thought that two separate brain centres control these two different types of responses;…
- An engaging month for LMB researchers
Over 30 LMB researchers have taken part in a range of activities as part of […]
- LMB student and postdoc prizes awarded to exceptional scientists
At the end of a highly stimulating LMB Lab Symposium, Jan Löwe, LMB Director and […]
- New Sosei Heptares R&D facility officially opens at Granta Park
- Venki Ramakrishnan talks about the impact of Greg Winter’s Nobel Prize-winning research on BBC World Service
- Cells respond to deletion of CAV1 by increasing synthesis of extracellular matrix.
Mendoza-Topaz, C., Nelson, G., Howard, G., Hafner, S., Rademacher, P., Frick, M., Nichols, BJ.
PLoS ONE 13(10): e0205306. (22nd October 2018)
- Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant.
Gahlon, HL., Walker, AR., Cisneros, GA., Lamers, MH., Rueda, DS.
Phys Chem Chem Phys [Epub ahead of print]. (22nd October 2018)
- Integration of Parallel Opposing Memories Underlies Memory Extinction.
Felsenberg, J., et al.
Cell 175(3): 709-722.e15. (18th October 2018)
- Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment.
Gait, MJ., Arzumanov, AA., McClorey, G., Godfrey, C., Betts, C., Hammond, S., Wood, MJA.
Nucleic Acid Ther [Epub ahead of print]. (16th October 2018)
- Mutations in the MAB_2299c TetR regulator confer cross-resistance to clofazimine and bedaquiline in Mycobacterium abscessus.
Richard, M., et al.
Antimicrob. Agents Chemother. [Epub ahead of print]. (15th October 2018)
- Joint X-ray/NMR structure refinement of multidomain/multisubunit systems.
Carlon, A., Ravera, E., Parigi, G., Murshudov, GN., Luchinat, C.
J. Biomol. NMR [Epub ahead of print]. (11th October 2018)
- Publisher Correction: Guided self-organization and cortical plate formation in human brain organoids.
Lancaster, MA., et al.
Nat. Biotechnol. 36(10): 1016. (11th October 2018)
See more Publications