The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Eleven Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Cytoplasmic dynein-1, a protein that transports cargos along microtubule tracks throughout the cell, binds to dynactin and cargo adaptor proteins to carry its cargos over long distances. Various cargos use different adaptors to recruit dynein for transport. Until now, it has not…
Previous work from KJ Patel’s group in the LMB’s PNAC Division revealed that aldehydes – such as acetaldehyde, a by-product of alcohol metabolism – can damage our DNA. Further research by the group showed that our cells are protected against these toxic…
- John Sulston (1942 – 2018)
John Sulston, Nobel Laureate and pioneering scientist on the techniques for mapping of genomes, died […]
- Michel Goedert is awarded The Brain Prize 2018
Michel Goedert from the LMB’s Neurobiology Division has been awarded the 2018 Brain Prize. Michel […]
- Differential roles for cryptochromes in the mammalian retinal clock.
Wong, JCY., et al.
FASEB J. : fj201701165RR [Epub ahead of print]. (21st March 2018)
- Repellent and Attractant Guidance Cues Initiate Cell Migration by Distinct Rear-Driven and Front-Driven Cytoskeletal Mechanisms.
Cramer, LP., Kay, RR., Zatulovskiy, E.
Curr. Biol. 28(6): 995-1004.e3. (19th March 2018)
- Prion-like protein aggregates exploit the RHO GTPase to cofilin-1 signaling pathway to enter cells.
Zhong, Z., Grasso, L., Sibilla, C., Stevens, TJ., Barry, N., Bertolotti, A.
EMBO J. 37(6). (15th March 2018)
- Creating a systematic database of secretory pathway proteins uncovers new cargo for COPI.
Weill, U., et al.
Traffic [Epub ahead of print]. (12th March 2018)
- Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells.
Wan, Q., Okashah, N., Inoue, A., Nehmé, R., Carpenter, B., Tate, CG., Lambert, NA.
J. Biol. Chem. [Epub ahead of print]. (9th March 2018)
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