• Photo of the new LMB building opened in 2012

LMB COVID response
 

You can now apply to the LMB International PhD Programme for October 2022 start.

About Us

The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.

Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.

The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.

The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.

Insight on Research

How cellular clocks within heart cells coordinate daily cardiac rhythms

Graphic showing raised beat rate during physical activity during the day, and lower beat rate during rest in the night. Heart clocks regulate the daily variation in heart rate – Each heart cell has a clock that regulates the frequency of firing rate between day and night. This helps the heart to beat faster during the day and to sustain daily activities.

Alessandra Stangherlin (O’Neill group) found a cellular mechanism that facilitates daily changes in heart rate. ~24h rhythms in Na/K/Cl levels osmotically compensate for daily changes in macromolecular crowding to modulate cardiac electrical activity, in vitro and in vivo.

Classification of human tauopathies based on tau filament folds

Chart showing the new hierarchical method to characterise tauopathies on the basis of their filament folds

Tau structures from range of neurological diseases revealed through cryo-EM analysis suggests a new way to characterise tauopathies on the basis of filament folds.

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