Kiyoshi Nagai (1949 – 2019)
It is with great sadness that the LMB has to report the death of Kiyoshi Nagai. Kiyoshi had just reached the pinnacle of his scientific career, unravelling the reaction cycle of the complex spliceosome. More…
We are accepting applications for PhD Studentships starting in 2020. Apply Now!
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Demonstration of a new direction in electron cryo-microscopy at the LMB promises a new era in resolving biological structures Is it possible to improve imaging of purified biological specimens in electron cryo-microscopy (cryo-EM) while also reducing its cost? The latest proof-of-principle paper from Chris Russo’s group says yes,
Structures of active Rag dimers bound to mTORC1 provide greater understanding of control of cell growth and identify potential targets for development of new cancer drugs Control of cell division is crucially important, as unregulated cell division is a hallmark of cancer.
- Mariann Bienz: Fascinating flies – Drosophila and the molecular biology of development and disease
The third in our series of Group Leader profiles written by science writer and LMB […]
- LMB raises £1,108 for cancer support and a children’s ambulance
For the fifth year in a row, LMB staff showed up on both sides of […]
- Greg Winter and the promise of antibody-based therapies
- Madeline Lancaster explains brain organoids to The Times
- Selection of 2'-Deoxy-2'-Fluoroarabino Nucleic Acid (FANA) Aptamers That Bind HIV-1 Integrase with Picomolar Affinity.
Rose, KM., Alves Ferreira-Bravo, I., Li, M., Craigie, R., Ditzler, MA., Holliger, P., DeStefano, JJ.
ACS Chem. Biol. 14(10): 2166-2175. (18th October 2019)
- Rare missense variants in the human cytosolic antibody receptor preserve antiviral function.
Zeng, J., Slodkowicz, G., James, LC.
Elife 8. (15th October 2019)
- Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome.
Renko, M., Fiedler, M., Rutherford, TJ., Schaefer, JV., Plückthun, A., Bienz, M.
Proc. Natl. Acad. Sci. U.S.A. 116(42): 20977-20983. (15th October 2019)
- Direct interplay between stereochemistry and conformational preferences in aminoacylated oligoribonucleotides.
Polyansky, AA., Kreuter, M., Sutherland, JD., Zagrovic, B.
Nucleic Acids Res. [Epub ahead of print]. (15th October 2019)
- Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Anandapadamanaban, M., et al.
Science 366(6462): 203-210. (11th October 2019)
- Convolutional neural network model to predict causal risk factors that share complex regulatory features.
Lee, T., Sung, MK., Lee, S., Yang, W., Oh, J., Kim, JY., Hwang, S., Ban, HJ., Choi, JK.
Nucleic Acids Res. [Epub ahead of print]. (10th October 2019)
- Architecture of the mycobacterial type VII secretion system.
Famelis, N., et al.
Nature [Epub ahead of print]. (9th October 2019)
See more Publications