• Photo of the new LMB building opened in 2012

About Us

The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.

Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.

The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.

The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.

Insight on Research

DNA replication initiation shapes the evolution and expression of the human genome

The study shows a signature associated with DNA breaks (blue area in the graph) is focussed on the centre of DNA replication origins. A signature associated with error prone DNA synthesis (red area in the graph) is found either side of the origins.

One of the universal events in the lifecycle of every cell is the initiation of genome duplication. Julian Sale’s group in the LMB’s PNAC Division have used high-resolution maps of human replication origins to demonstrate the mutagenic properties of DNA replication origins.

Refactoring the genetic code to create organisms protected by a genetic firewall

Refactoring the genetic code to create organisms protected by a genetic firewall.

Jason Chin’s group refactor the genetic code to create genetically isolated organisms which cannot exchange genetic information with naturally-occurring organisms in the environment.

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Latest News

  • Group leaders, Kelly Nguyen and Ben Ryskeldi-Falcon, are elected to join the EMBO Young Investigator Programme (YIP).EMBO announces 2023 elections for Young Investigator Programme

    Kelly Nguyen and Benjamin Ryskeldi-Falcon have been elected into the EMBO Young Investigator Programme for a four-year tenure starting January 2023. During this time EMBO will provide financial and practical support as well as networking opportunities for the Young Investigators and their lab members. […]

  • Tanmay BharatTanmay Bharat wins the 2023 Microbiology Society Fleming Prize

    Tanmay Bharat is awarded the 2023 Microbiology Society Fleming Prize. His research uses electron tomography to study prokaryotic cell surfaces, playing important roles in prokaryotic physiology, as well in human bacterial infections. […]

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Latest Publications

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