• Photo of the new LMB building opened in 2012

About Us

The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.

Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.

The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.

The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.

Insight on Research

Identification of pathway that enables resistance to tuberculosis

Mycobacteria rapidly kill infected mTOR-deficient macrophages during the early stages of granuloma formation, leading to premature granuloma necrosis, which releases mycobacteria into the growth-promoting extracellular space.

Lalita Ramakrishnan’s group, LMB Cell Biology Division and University of Cambridge Molecular Immunity Unit, has determined that increased metabolism, prompted through mTOR kinase, is a crucial resistance factor against macrophage necrosis during TB infection.

Identical structures of α-synuclein filaments from Parkinson’s disease and dementia with Lewy bodies

The groups of Michel Goedert and Sjors Scheres, from the LMB’s Neurobiology and Structural Studies Divisions, have used cryo-EM to identify identical structures of α-synuclein filaments from Parkinson’s disease and dementia with Lewy bodies.

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Latest News

  • John Jarvis (1942 – 2022)

    John Jarvis, a former research assistant, who spent nearly 40 years at the LMB working alongside César Milstein, died on Thursday 1st September 2022, aged 80 […]

  • Holger KramerHolger Kramer (1979 – 2022)

    Holger Kramer, Head of the LMB’s Mass Spectrometry facility, and a highly interactive, inquisitive and engaged scientist, died on Tuesday 23rd August 2022, aged 43. […]

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Latest Publications

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