The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
New insights into the architecture of organelle contact sites, and the sites’ roles in cellular lipid fluxes
By combining fluorescence microscopy and electron tomography, Wanda Kukulski’s lab in Cell Biology Division has visualised protein structures that bridge contact sites between the endoplasmic reticulum and plasma membrane in yeast, in their native environment i.e. within the cell.
Cells tightly control the levels of ‘housekeeping’ proteins to maintain smooth operation of basic life processes. The most common way cells accomplish this task is feedback control of transcription to turn on or turn off genes in response to perceived need of their protein products.
- The LMB welcomes Marta Zlatic as a new Group Leader
The LMB is delighted to announce the appointment of Marta Zlatic as a Group Leader […]
- The LMB welcomes Albert Cardona as a new Group Leader
The LMB is delighted to announce the appointment of Albert Cardona as a Group Leader […]
- Cambridge Independent features the future of LMB’s Nobel-winning technology
- Nature’s 150th anniversary issue celebrates Georges Köhler, Cesar Milstein and Greg Winter’s pioneering role in the rise of monoclonal antibodies
- Mechanistic insights into mRNA 3'-end processing.
Kumar, A., Clerici, M., Muckenfuss, LM., Passmore, LA., Jinek, M.
Curr. Opin. Struct. Biol. 59: 143-150. (6th December 2019)
- Structure of the Fanconi anaemia monoubiquitin ligase complex.
Shakeel, S., et al.
Nature 575(7781): 234-237. (30th November 2019)
- ChemBioChem@20-Some Reflections.
Fersht, AR., Gölitz, P., Lehn, JM.
Chembiochem [Epub ahead of print]. (26th November 2019)
- Brain Organoids: Human Neurodevelopment in a Dish.
Benito-Kwiecinski, S., Lancaster, MA.
Cold Spring Harb Perspect Biol [Epub ahead of print]. (25th November 2019)
- Mechanism of ribosome stalling during translation of a poly(A) tail.
Chandrasekaran, V., et al.
Nat. Struct. Mol. Biol. [Epub ahead of print]. (25th November 2019)
- Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.
Holzer, S., et al.
Nucleic Acids Res. [Epub ahead of print]. (22nd November 2019)
- The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.
Harding, HP., Ordonez, A., Allen, F., Parts, L., Inglis, AJ., Williams, RL., Ron, D.
Elife 8 [Epub ahead of print]. (21st November 2019)
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