• Photo of the new LMB building opened in 2012

About Us

The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.

Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.

The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.

The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.

Insight on Research

Functional human replisome reconstituted for the first time

Replisome performing DNA replication

A new study from Joe Yeeles’ group, in the LMB’s PNAC Division, demonstrates the first reconstitution of a functional human replisome that performs fast and efficient DNA replication.

Proteins required for processing the end of mRNAs identified

CryoEM structure of the polymerase module of CPF in complex with RNA, the PSR of Mpe1 and the yPIM of Cft2. The structure shows how Mpe1 (orange) directly contacts RNA (gray), and Cft2 (light blue) binds to the polymerase module of the yeast cleavage and polyadenylation factor (CPF).

Lori Passmore’s group in the LMB’s Structural Studies Division has shown that Mpe1 in yeast and RBBP6 in humans are critical for activating CPF and CPSF respectively, protein complexes vital to cleavage process of mRNA.

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Latest Publications


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