Kiyoshi Nagai (1949 – 2019)

It is with great sadness that the LMB has to report the death of Kiyoshi Nagai. Kiyoshi had just reached the pinnacle of his scientific career, unravelling the reaction cycle of the complex spliceosome. More

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About Us

The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.

Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.

The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.

The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.

Insight on Research

Fast, simple, accessible and affordable: The future of cryo-EM

A 3D reconstruction of hepatitis B virus capsid at 100 keV

Demonstration of a new direction in electron cryo-microscopy at the LMB promises a new era in resolving biological structures Is it possible to improve imaging of purified biological specimens in electron cryo-microscopy (cryo-EM) while also reducing its cost? The latest proof-of-principle paper from Chris Russo’s group says yes,

Structural insights into control of cell growth by nutrient availability

mTORC1 recruited to a lysosome by Rag GTPases in order to be activated by RHEB

Structures of active Rag dimers bound to mTORC1 provide greater understanding of control of cell growth and identify potential targets for development of new cancer drugs Control of cell division is crucially important, as unregulated cell division is a hallmark of cancer.

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Latest Publications

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