In line with government instructions, the LMB buildings are closed since midnight, 24 March as part of our efforts to suppress the spread of COVID-19. Only essential staff and those that contribute to the fight against COVID-19 are allowed access. The buildings will remain closed for three weeks in the first instance, after which the situation will be reviewed.
All other staff are working from home and all internal and external meetings are being held via video or teleconferencing. Please use email as the preferred means of contacting members of LMB.
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Alcohol consumption can indirectly cause damage to our DNA and elevate cancer risk. KJ Patel’s group in the LMB’s PNAC Division has identified a novel repair mechanism for DNA damage created by by-products of alcohol metabolism.
New study, led by Pablo Alcón and Shabih Shakeel in Lori Passmore’s group, in collaboration with KJ Patel in the PNAC Division, uncovers a unique molecular “clamp and pin” mechanism that activates the D2l complex, which then recruits enzymes that cut out damaged DNA
- Daffodils announce LMB staff’s fundraising for Marie Curie
Led by Freda Chapman at the LMB, our staff raised £695 for Marie Curie, a registered charitable organisation, which provides care and support to people with terminal illnesses and their families. […]
- Paul Dear (1962 – 2020)
Paul Dear, former Group Leader in the LMB’s PNAC Division, died on Wednesday 11th March 2020. Paul was most interested in developing new methods and technologies to improve research and information gathering, particularly in genomics. […]
- α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species.
Morgan, SA., et al.
J. Biol. Chem. [Epub ahead of print]. (24th March 2020)
- Distinct effects on mRNA export factor GANP underlie neurological disease phenotypes and alter gene expression depending on intron content.
Woldegebriel, R., et al.
Hum. Mol. Genet. [Epub ahead of print]. (23rd March 2020)
- Recurrent architecture for adaptive regulation of learning in the insect brain.
Eschbach, C., et al.
Nat. Neurosci. [Epub ahead of print]. (23rd March 2020)
- Structural basis of G-quadruplex DNA recognition by the yeast telomeric protein Rap1.
Traczyk, A., Liew, CW., Gill, DJ., Rhodes, D.
Nucleic Acids Res. [Epub ahead of print]. (18th March 2020)
- Potential benefit of manipulating protein quality control systems in neurodegenerative diseases.
Luh, LM., Bertolotti, A.
Curr. Opin. Neurobiol. 61: 125-132 [Epub ahead of print]. (18th March 2020)
- Facile generation of giant unilamellar vesicles using polyacrylamide gels.
Parigoris, E., et al.
Sci Rep 10(1): 4824. (16th March 2020)
- Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila.
Hervas, R., Rau, MJ., Park, Y., Zhang, W., Murzin, AG., Fitzpatrick, JAJ., Scheres, SHW., Si, K.
Science 367(6483): 1230-1234. (13th March 2020)
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