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About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
How the brain orchestrates head movement
While reaching for our morning cup of coffee, we experience the movement of our arm as continuous and smooth. It is natural then to think that the representation of these movements in our brain would also be continuous and smooth. Studying how such target-oriented movements are controlled,
New cell death pathway in tuberculosis indicates potential use of commonly used drugs
Macrophages are a critical part of our immune system. They patrol our tissues, and when they encounter debris or invaders such as bacteria and parasites, they engulf the particles and destroy them. But if, in the course of tuberculosis, these infected macrophages die through a process called necrosis,
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Latest News
The LMB welcomes Jing Ren as a new Group LeaderThe LMB is delighted to announce the appointment of Jing Ren as a Group Leader […]
Future scientists and science leaders visit the LMBThe LMB recently hosted visits from two diverse groups of students; one that was attending […]
Latest Publications
- Regulation of the endosomal SNX27-retromer by OTULIN.
Stangl, A., et al.
Nat Commun 10(1): 4320. (20th September 2019) - Structures of Respiratory Supercomplex I+III Reveal Functional and Conformational Crosstalk.
Letts, JA., Fiedorczuk, K., Degliesposti, G., Skehel, M., Sazanov, LA.
Mol. Cell 75(6): 1131-1146.e6. (19th September 2019) - An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.
Perera, LA., Rato, C., Yan, Y., Neidhardt, L., McLaughlin, SH., Read, RJ., Preissler, S., Ron, D.
EMBO J. : e102177 [Epub ahead of print]. (18th September 2019) - Harnessing Evolution to Make Medicines (Nobel Lecture).
Winter, G.
Angew. Chem. Int. Ed. Engl. [Epub ahead of print]. (17th September 2019) - Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice.
Lavenir, I., Passarella, D., Masuda-Suzukake, M., Curry, A., Holton, JL., Ghetti, B., Goedert, M.
Acta Neuropathol Commun 7(1): 148. (16th September 2019) - In vivo DNA assembly using common laboratory bacteria: a re-emerging tool to simplify molecular cloning.
Watson, JF., García-Nafría, J.
J. Biol. Chem. [Epub ahead of print]. (14th September 2019) - Activity-Dependent Regulation of the Proapoptotic BH3-Only Gene egl-1 in a Living Neuron Pair in Caenorhabditis elegans.
Cohn, J., Dwivedi, V., Valperga, G., Zarate, N., de Bono, M., Horvitz, HR., Pierce, JT.
G3 (Bethesda) [Epub ahead of print]. (13th September 2019)
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