The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Alessandra Stangherlin (O’Neill group) found a cellular mechanism that facilitates daily changes in heart rate. ~24h rhythms in Na/K/Cl levels osmotically compensate for daily changes in macromolecular crowding to modulate cardiac electrical activity, in vitro and in vivo.
Tau structures from range of neurological diseases revealed through cryo-EM analysis suggests a new way to characterise tauopathies on the basis of filament folds.
- Students and postdocs’ exemplary research recognised by 2021 Perutz and Brenner Prizes
LMB PhD students and postdocs are awarded for breakthroughs in human brain development, DNA replication, yeast GPCRs, dynein motor delivery and ubiquitylation of LPS. […]
- Michel Goedert awarded the 2021 Hartwig Piepenbrock-DZNE Prize
Michel Goedert has been awarded the 2021 Hartwig Piepenbrock-DZNE prize for his work on the molecular mechanisms of neurodegenerative diseases, including Alzheimer’s and Parkinson’s. […]
- Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity.
Wilcox, AG., et al.
iScience 24(10): 103142. (22nd October 2021)
- Dissemination of Mycobacterium abscessus via global transmission networks.
Ruis, C., et al.
Nat Microbiol 6(10): 1279-1288. (20th October 2021)
- Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.
Morris, EL., Patton, AP., Chesham, JE., Crisp, A., Adamson, A., Hastings, MH.
EMBO J 40(20): e108614. (18th October 2021)
- Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.
Stangherlin, A., et al.
Nat Commun 12(1): 6035. (15th October 2021)
- Oncogenic instructs morphological transformation of human epithelia via differential tissue mechanics.
Nyga, A., et al.
Sci Adv 7(42): eabg6467. (15th October 2021)
- Correction to: Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study.
López-Méndez, B., et al.
Eur Biophys J [Epub ahead of print]. (15th October 2021)
- Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase.
Faheem, M., et al.
Biochem J 478(19): 3655-3670. (15th October 2021)
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