Applications for the LMB PhD programme are now open. Deadline 3rd December 2024.
About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
Unprecedented heteromeric amyloid structure in neurodegenerative disease
Surprising advance to our understanding of neurodegenerative diseases, as Diana Arseni and Benjamin Ryskeldi-Falcon in the LMB’s Neurobiology Division find that frontotemporal lobar degeneration Type C filaments include both annexin A11 and TDP-43 in a unique heteromeric structure.
How cells enter the germline at the right time and place during embryonic development
Marta Shahbazi’s group in the LMB’s Cell Biology Division has determined that contact with extracellular matrix proteins prevents embryonic cells from becoming germ cells.
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Latest News
- Diana Arseni appointed Group Leader in the LMB’s Neurobiology Division
Diana Arseni’s research group in the LMB’s Neurobiology Division will study mechanisms of brain health, ageing and disease focusing on the lysosomal protein TMEM106B. […]
- Poppy Marriott appointed Scientific Services and Sustainability Manager
The LMB is thrilled to announce that Poppy Marriott was recently appointed as the new Scientific Services and Sustainability Manager. […]
Latest Publications
- A Fragment-Based Competitive F LB-NMR Platform For Hotspot-Directed Ligand Profiling.
McCarthy, WJ., et al.
Angew Chem Int Ed Engl 63(37): e202406846. (9th September 2024) - Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication.
Pauciullo, S., et al.
Cell Mol Life Sci 81(1): 386. (7th September 2024) - Integrin signaling in pluripotent cells acts as a gatekeeper of mouse germline entry.
Makhlouf, A., Wang, A., Sato, N., Rosa, VS., Shahbazi, MN.
Sci Adv 10(36): eadk2252. (6th September 2024) - Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors.
Clark, PA., et al.
Nat Commun 15(1): 7809. (6th September 2024) - Engineering Pyrrolysine Systems for Genetic Code Expansion and Reprogramming.
Dunkelmann, DL., Chin, JW.
Chem Rev [Epub ahead of print]. (5th September 2024) - Behavioral plasticity.
Zhang, Y., Iino, Y., Schafer, WR.
Genetics 228(1). (4th September 2024) - Using Organoids to Model Sex Differences in the Human Brain.
Pavlinek, A., et al.
Biol Psychiatry Glob Open Sci 4(5): 100343. (4th September 2024)
See more Publications