The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Using synthetic biological techniques, Michael Hastings’ group have collaborated with Jason Chin to gain novel insights into the molecular and cellular processes which govern the suprachiasmatic nucleus, and identified a key regulatory role of cryptochrome clock proteins.
Atomic structures of Aβ42 filaments from the brains of individuals with Alzheimer’s disease and other neurodegenerative conditions
Collaboration between Sjors Scheres’ (Structural Studies), Benjamin Ryskeldi-Falcon’s and Michel Goedert’s (both Neurobiology) groups have used cryo-EM to reveal structures of Aβ42 filaments, the key factor behind the pathogenesis of Alzheimer’s disease.
- Madeline Lancaster recognised in the 2022 Blavatnik Awards
Madeline Lancaster is honoured as Laureate for Life Sciences in the 2022 Blavatnik Award for Young Scientists in the UK for her research of human brain development using organoids. […]
- LMB raises over £1500 for Addenbrooke’s Charitable Trust
- Integrated wafer-scale manufacturing of electron cryomicroscopy specimen supports.
Naydenova, K., Russo, CJ.
Ultramicroscopy 232: 113396. (19th January 2022)
- Androgens increase excitatory neurogenic potential in human brain organoids.
Kelava, I., Chiaradia, I., Pellegrini, L., Kalinka, AT., Lancaster, MA.
Nature [Epub ahead of print]. (19th January 2022)
- Development of Inhibitors of SAICAR Synthetase (PurC) from Using a Fragment-Based Approach.
Charoensutthivarakul, S., et al.
ACS Infect Dis [Epub ahead of print]. (17th January 2022)
- The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly.
Tischer, T., Yang, J., Barford, D.
J Cell Sci 135(2). (15th January 2022)
- Structure and function of a family of tick-derived complement inhibitors targeting properdin.
Braunger, K., Ahn, J., Jore, MM., Johnson, S., Tang, TTL., Pedersen, DV., Andersen, GR., Lea, SM.
Nat Commun 13(1): 317. (14th January 2022)
- Cryo-EM structures of amyloid-β 42 filaments from human brains.
Yang, Y., et al.
Science 375(6577): 167-172. (14th January 2022)
- Compressed sensing for electron cryotomography and high-resolution subtomogram averaging of biological specimens.
Böhning, J., Bharat, TAM., Collins, SM.
Structure [Epub ahead of print]. (11th January 2022)
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