• Photo of the new LMB building opened in 2012

About Us

The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.

Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.

The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.

The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.

Insight on Research

Pathway behind pathogenic mechanism of tuberculosis identified

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New research from Lalita Ramakrishnan’s group, LMB Cell Biology Division and University of Cambridge Molecular Immunity Unit, has revealed the reverse electron transport pathway behind mitochondrial reactive oxygen species overproduction, contributing to tuberculosis pathogenesis.

Clinical study reveals striking daily temperature variation in the human brain that predicts survival after brain injury

Temperature scale on the left hand side, using a colour scale that is mirrored in the brain on the right hand side which illustrates the varying temperatures across brain regions

A clinical study, led by Nina Rzechorzek in John O'Neill's group at the LMB, showed that healthy human brain temperature varies far more than previously assumed—by age, sex, brain region, and time of day. This has major implications for patients, suggesting that daily rhythmic brain temperature variation is critical to brain function.

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