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About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
A genome-wide resource for dissecting transport within cells
Chun Hao Wong and Simon Bullock, from the LMB’s Cell Biology Division, together with Douglas Ross-Thriepland and colleagues at AstraZeneca, have systematically disrupted every gene in cultured human cells to reveal a large number of new factors required for organisation of cells by the microtubule motor dynein.
New insights into genetic mechanisms involved in kidney development
John-Poul Ng-Blichfeldt and Katja Röper, in the LMB’s Cell Biology Division, have collaborated with Julie Williams from AstraZeneca, to use renal organoids to investigate the human mesenchymal-to-epithelial transition, crucial to the morphogenesis of kidneys.
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Latest News
- Marta Shahbazi wins Suffrage Science award
Marta Shahbazi, Group Leader in the LMB’s Cell Biology Division, has been announced as one of the 2024 recipients in the Life Sciences category. […]
- Sofia Lövestam wins Weintraub Graduate Student Award
Sofia Lövestam has been recognised for her Ph.D. research in the LMB’s Structural Studies and Neurobiology Divisions investigating in vitro amyloid assemblies to study neurodegenerative diseases. […]
Latest Publications
- Molecular mechanisms of the RNA polymerases in plant RNA-directed DNA methylation.
Xie, G., Du, X., Hu, H., Du, J.
Trends Biochem Sci 49(3): 247-256. (9th March 2024) - The molecular basis of translation initiation and its regulation in eukaryotes.
Brito Querido, J., Díaz-López, I., Ramakrishnan, V.
Nat Rev Mol Cell Biol 25(3): 168-186. (5th March 2024) - Accurate magnification determination for cryoEM using gold.
Dickerson, JL., Leahy, E., Peet, MJ., Naydenova, K., Russo, CJ.
Ultramicroscopy 256: 113883. (15th February 2024) - A Dose-Finding Study to Guide Use of Verapamil as an Adjunctive Therapy in Tuberculosis.
Padmapriyadarsini, C., et al.
Clin Pharmacol Ther 115(2): 324-332. (11th February 2024) - From connectome to effectome: learning the causal interaction map of the fly brain.
Pospisil, DA., et al.
bioRxiv [Epub ahead of print]. (9th February 2024) - Community recommendations on cryoEM data archiving and validation: Outcomes of a wwPDB/EMDB workshop on cryoEM data management, deposition and validation.
Kleywegt, GJ., et al.
ArXiv [Epub ahead of print]. (2nd February 2024) - Tracking early mammalian organogenesis - prediction and validation of differentiation trajectories at whole organism scale.
Imaz-Rosshandler, I., et al.
Development 151(3). (1st February 2024)
See more Publications