The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
One of the universal events in the lifecycle of every cell is the initiation of genome duplication. Julian Sale’s group in the LMB’s PNAC Division have used high-resolution maps of human replication origins to demonstrate the mutagenic properties of DNA replication origins.
Jason Chin’s group refactor the genetic code to create genetically isolated organisms which cannot exchange genetic information with naturally-occurring organisms in the environment.
- EMBO announces 2023 elections for Young Investigator Programme
Kelly Nguyen and Benjamin Ryskeldi-Falcon have been elected into the EMBO Young Investigator Programme for a four-year tenure starting January 2023. During this time EMBO will provide financial and practical support as well as networking opportunities for the Young Investigators and their lab members. […]
- Tanmay Bharat wins the 2023 Microbiology Society Fleming Prize
Tanmay Bharat is awarded the 2023 Microbiology Society Fleming Prize. His research uses electron tomography to study prokaryotic cell surfaces, playing important roles in prokaryotic physiology, as well in human bacterial infections. […]
- Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane.
Lisica, A., et al.
Proc Natl Acad Sci U S A 119(49): e2201600119. (6th December 2022)
- Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum.
Rodriguez-Rodriguez, N., et al.
Proc Natl Acad Sci U S A 119(49): e2203454119. (6th December 2022)
- A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0.
Zivanov, J., et al.
Elife 11 [Epub ahead of print]. (5th December 2022)
- Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity.
Sandhu, M., et al.
Nat Commun 13(1): 7428. (2nd December 2022)
- Variability in X-ray induced effects in [Rh(COD)Cl] with changing experimental parameters.
Fernando, NK., et al.
Phys Chem Chem Phys 24(46): 28444-28456. (30th November 2022)
- Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states.
Hardege, I., Morud, J., Yu, J., Wilson, TS., Schroeder, FC., Schafer, WR.
Proc Natl Acad Sci U S A 119(48): e2201783119. (29th November 2022)
- Author Correction: Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility.
Futamata, H., et al.
Nat Commun 13(1): 7337. (28th November 2022)
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