About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
Germ cells need DNA crosslink repair to develop normally
Germ cells face a significant threat to their genetic integrity during embryonic development. Ross Hill and Gerry Crossan, of the Crossan Group in the LMB’s PNAC Division, have recently found that these cells need a specific form of DNA repair, known as crosslink repair,
Activation of lysosomes allows worms to live longer and may protect against neurodegenerative diseases
Ageing is a growing problem for society, particularly because of the associated increased risk of developing disease. Understanding how we might be able to live healthier for longer is a key goal of medical research. The nematode worm C. elegans is a commonly used model for studying the changes that take place as animals age.
Quick Links
Latest News
Future scientists and science leaders visit the LMBThe LMB recently hosted visits from two diverse groups of students; one that was attending […]
The LMB welcomes Benjamin Falcon as a new Group LeaderThe LMB is delighted to announce the appointment of Benjamin Falcon as a Group Leader […]
Latest Publications
- Direct quantification of the translocation activities of Saccharomyces cerevisiae Pif1 helicase.
Lu, C., Le, S., Chen, J., Byrd, AK., Rhodes, D., Raney, KD., Yan, J.
Nucleic Acids Res. 47(14): 7494-7501. (22nd August 2019) - Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Wrobel, AG., et al.
Dev. Cell 50(4): 494-508.e11. (19th August 2019) - Author Correction: The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Tang, TTL., Stowell, JAW., Hill, CH., Passmore, LA.
Nat. Struct. Mol. Biol. [Epub ahead of print]. (16th August 2019) - Author Correction: Exploring the Sequence-based Prediction of Folding Initiation Sites in Proteins.
Raimondi, D., Orlando, G., Pancsa, R., Khan, T., Vranken, WF.
Sci Rep 9(1): 12140. (15th August 2019) - Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid.
James, LC., Böcking, T.
Cell Host Microbe 26(2): 151-153. (14th August 2019) - Fluorescence-Based Detection of Membrane Fusion State on a Cryo-EM Grid using Correlated Cryo-Fluorescence and Cryo-Electron Microscopy.
Metskas, LA., Briggs, JAG.
Microsc. Microanal. 25(4): 942-949. (14th August 2019) - Insights into ubiquitin chain architecture using Ub-clipping.
Swatek, KN., et al.
Nature [Epub ahead of print]. (14th August 2019)
See more Publications