The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
DNA damage caused by formaldehyde is repaired involving CSA and CSB genes. KJ Patel’s lab have shown how, when this pathway is mutated such as in people with Cockayne syndrome, the appetite suppression hormone GDF15 is released leading to severe weight loss.
Early transcriptional patterning of a forming tissue is essential to morphogenesis of a tubular organ
Time-lapse quantitative study of developing salivary glands in Drosophila embryos, conducted by Katja Röper’s group, reveals the key control factors behind cells’ behavioural transitions that are essential for correct organ formation.
- César Milstein Lecture to be given by Hans Clevers
Hans Clevers from the Hubrecht Institute will deliver the 2021 César Milstein Lecture on how organoids can be used to model human diseases. […]
- Francis Crick Lecture to be given by Michel C. Nussenzweig
Michel C Nussenzweig from Rockefeller University will deliver the 2021 Francis Crick Lecture on human immune responses to SARS-CoV-2 infection or vaccination […]
- Substrate recognition determinants of human eIF2α phosphatases.
Hodgson, G., Andreeva, A., Bertolotti, A.
Open Biol 11(12): 210205. (1st December 2021)
- Cryo-EM structures of τ filaments from human brain.
Essays Biochem [Epub ahead of print]. (30th November 2021)
- CRYPTOCHROMES promote daily protein homeostasis.
Wong, DCS., et al.
EMBO J : e2021108883 [Epub ahead of print]. (29th November 2021)
- Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.
Macdonald, JA., et al.
Acta Neuropathol Commun 9(1): 189. (24th November 2021)
- Publisher Correction: Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.
Stangherlin, A., et al.
Nat Commun 12(1): 6988. (24th November 2021)
- Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.
Mulderrig, L., et al.
Nature [Epub ahead of print]. (24th November 2021)
- Epigenetics and tissue immunity-Translating environmental cues into functional adaptations.
Tuong, ZK., Stewart, BJ., Guo, SA., Clatworthy, MR.
Immunol Rev [Epub ahead of print]. (24th November 2021)
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