John-Poul Ng-Blichfeldt and Katja Röper, in the LMB’s Cell Biology Division, have collaborated with Julie Williams from AstraZeneca, to use renal organoids to investigate the human mesenchymal-to-epithelial transition, crucial to the morphogenesis of kidneys.
Anne Bertolotti’s group in the LMB Neurobiology Division have revealed the substrate recruitment mechanism of major phosphatase non-catalytic subunit, PPP1R15B, by using full-length eIF2 and a combination of approaches.
Time-resolved study of in vitro assembly of truncated tau by the groups of Sjors Scheres and Michel Goedert, from the LMB’s Structural Studies and Neurobiology Divisions, identifies formation of many different disease-specific intermediate amyloid filaments.
Structure of the outer kinetochore bound to microtubules, determined by David Barford’s group in the Structural Studies Division, reveals how phosphorylation regulates mitotic spindle chromosome attachment errors to ensure DNA is equally segregated into two daughter cells.
The discovery of TAF15 amyloid filaments in patients with frontotemporal lobar degeneration by the group of Benjamin Ryskeldi-Falcon in the LMB’s Neurobiology Division establishes this protein as a diagnostic and therapeutic target for this neurodegenerative disorder.
A collaborative team lead by Chris Russo’s group in the LMB’s Structural Studies Division has developed a new electron cryo-microscope, capable of solving atomic structures at a fraction of the energy and cost of existing models.