![Image of a human lung showing the immune response to allergen, highlighting that αvβ3 integrin mediates the formation of TH2 cell clusters, which promotes inflammatory cytokine expression and allergic responses.](https://www2.mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/Integrin-mediated-TH2-clusters-150x150.jpg)
Researchers in Andrew McKenzie’s group, in the LMB’s PNAC Division, have used high-throughput CRISPR screening to identify a role for alpha V beta 3 integrin in IL-13 production which contributes to unwanted inflammation during an asthma or allergic immune response.