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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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New machinery for membrane protein insertion

Squalene synthase, a membrane protein, becomes mislocalised when EMC does not function.

The human genome encodes approximately 5000 membrane-embedded proteins that carry out many essential processes such as cell-to-cell communication, cell adhesion and intracellular trafficking. Almost all of these proteins are assembled at the endoplasmic reticulum (ER) by molecular machines that guide them into the membrane. Because these thousands of membrane proteins are highly diverse in size, shape and charge, different machines are needed for different types of membrane proteins.

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Published on 15th December, 2017

Trim-Away: powerful new tool for studying protein function

All the cells in our body contain thousands of proteins, molecular machines which carry out almost all biological processes that are essential for life. Many diseases, such as cancer and neurodegeneration, are caused when these protein machines go wrong. Thus it has been a long-term goal in science to characterise the functions of proteins within our cells.

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Published on 17th November, 2017

Spliceosome catalysis: the completed puzzle

RNA at the core of the spliceosome.

The spliceosome is a molecular machine that plays an important role in gene expression. It cuts non-coding sequences (introns) out of messenger RNA (mRNA) precursors, and stitches together the useful coding sequences (exons). The spliceosome performs this in two steps. First, the start of an intron is recognised, cut, and joined to a specific point in the middle of that intron, forming a lasso-like looped structure.

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Published on 17th November, 2017

Human wound healing is affected by the body clock

Internal body clocks, which time the length of a day in almost all organisms, control many aspects of human physiology and activity, from when we go to bed to when we perform best mentally and physically. Most importantly, these biological circadian clocks are in every single individual cell of our bodies, not just in the brain.

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Published on 9th November, 2017

New insights into ubiquitin phosphorylation and the development of early-onset Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative condition caused by the loss of dopaminergic neurons in the midbrain, which manifests clinically in the form of characteristic motor defects. Most PD cases are sporadic and found in people above the age of 60. However, roughly 10% of PD cases are autosomal recessive juvenile forms (AR-JP), causing early-onset PD.  It is known that mutations in PARK genes are responsible for this, but often a molecular explanation is lacking.

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Published on 31st October, 2017

The missing link between golgins and endosomal vesicles discovered

A model for the role of TBC1D23 as a link between the trans-Golgi network golgins and FAM21A of the WASH complex on endosome-derived vesicles.

Inside our cells there are many distinct membrane compartments – organelles – which carry out the different tasks that allow the cell to function. Each organelle is like a factory that requires a constant supply of raw materials to stay active. Small transport vesicles deliver this cargo of particular proteins and lipids to each organelle.

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Published on 30th October, 2017
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