Electron Cryo-microscopy

LMB scientists have been and continue to be at the forefront of the field of electron cryo-microscopy, developing a technique which allows biological molecules to be visualised at the atomic level. In 2017 the LMB’s Richard Henderson won the Nobel Prize for Chemistry, along with Jacques Dubochet and Joachim Frank, for ‘developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution’. Find out more about their Nobel Prize.

Electron Cryo-microscopy Film

Electron Cryo-microscopy in Research

Read about cutting edge research from the LMB that has used electron cryo-microscopy.

Uncovering the structure of the serotonin receptor

G protein-coupled receptor

Controlling actin polymerisation in clathrin mediated endocytosis

Clathrin mediated endocytosis

How the poly(A) tail is added to the end of mRNAs

polymerase module structure

First atomic structures of Tau filaments from Alzheimer’s disease brain

Tau filament structures

First 3D structure of the complete human dynein

Process of dynein’s activation