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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

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HIV-1 needs the cell metabolite IP6 to build its capsid and infect cells

The HIV-1 immature lattice enriches IP6 into virions to catalyse mature capsid assembly.

In an international collaboration led by Leo James’ group, researchers have discovered that HIV-1 builds its capsid using a metabolite called IP6 that it captures from cells with a net-like protein lattice. Disabling this capture mechanism prevents capsid construction and renders HIV-1 non-infectious.

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Published on 9th January, 2023

Integrin-mediated T helper 2 cell clustering revealed as key step and potential therapeutic target in allergic immune response

Image of a human lung showing the immune response to allergen, highlighting that αvβ3 integrin mediates the formation of TH2 cell clusters, which promotes inflammatory cytokine expression and allergic responses.

Researchers in Andrew McKenzie’s group, in the LMB’s PNAC Division, have used high-throughput CRISPR screening to identify a role for alpha V beta 3 integrin in IL-13 production which contributes to unwanted inflammation during an asthma or allergic immune response.

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Published on 22nd December, 2022

DNA replication initiation shapes the evolution and expression of the human genome

The study shows a signature associated with DNA breaks (blue area in the graph) is focussed on the centre of DNA replication origins. A signature associated with error prone DNA synthesis (red area in the graph) is found either side of the origins.

One of the universal events in the lifecycle of every cell is the initiation of genome duplication. Julian Sale’s group in the LMB’s PNAC Division have used high-resolution maps of human replication origins to demonstrate the mutagenic properties of DNA replication origins.

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Published on 10th November, 2022

Refactoring the genetic code to create organisms protected by a genetic firewall

Refactoring the genetic code to create organisms protected by a genetic firewall.

Jason Chin’s group refactor the genetic code to create genetically isolated organisms which cannot exchange genetic information with naturally-occurring organisms in the environment.

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Published on 24th October, 2022

Pathway for making multipass membrane proteins elucidated

Structural model for the multipass translocon bound to a translating ribosome at the endoplasmic reticulum membrane, where membrane proteins are made.

New research by the Hegde group and collaborators has used a combination of biochemical and structural approaches to reveal the key factors and steps cells use to embed multipass proteins, such as GPCRs and transporters, into the membrane.

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Published on 19th October, 2022

Engineered polymerase enzyme presents new opportunity for quick and efficient modified nucleic acid synthesis

Larger and larger modifications to the canonical nucleic acid structure

Modified polymerase enzyme produces xeno-nucleic acids efficiently and accurately, opening up possibilities in academic science, pharmaceuticals and biotechnology.

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Published on 13th October, 2022
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