![Cryo-EM structure of TAF15 and brain.](https://www2.mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/Ryskeldi-Falcon_Nature_TAF15_MRC_LMB_Image-brain_sq-150x150.png)
The discovery of TAF15 amyloid filaments in patients with frontotemporal lobar degeneration by the group of Benjamin Ryskeldi-Falcon in the LMB’s Neurobiology Division establishes this protein as a diagnostic and therapeutic target for this neurodegenerative disorder.