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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

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Asgard archaea proteins reveal evolutionary secrets of membrane remodelling

Evolution, structure and membrane remodelling function of the ESCRT-III superfamily in eukaryotes and their closest relatives Asgard archaea. The two subfamilies, B-type and A-type, have distinct structural properties to perform sequential steps of the membrane remodelling pathway.

Studying Asgard archaea, Buzz Baum’s group in the LMB’s Cell Biology Division and Aurelien Roux’s group at the University of Geneva, provide insights into the earliest origins of ESCRT-III and reveal how its proteins work together to remodel membranes.

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Published on 11th February, 2025

Newly identified quality control mechanism of RNA Polymerase II transcription

Ana Tufegdžić Vidaković’s group, in the LMB’s PNAC Division, have worked with Scott Berry’s group, at the University of New South Wales, to identify the mechanism cells use to regulate gene expression via control of quality and quantity of Pol II molecules.

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Published on 11th December, 2024

Discovery of a factor that accelerates protein deliveries to the endoplasmic reticulum

Huping Wang and Manu Hegde, in the LMB’s Cell Biology Division, have found a factor that helps nascent secretory and membrane proteins quickly access the protein translocation machinery when they arrive at the endoplasmic reticulum.

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Published on 29th November, 2024

Cryo-ET reveals new molecular insights into tau pathology in Alzheimer’s disease

Benjamin Ryskeldi-Falcon’s group in the LMB’s Neurobiology Division have used cryo-ET to discover that tau filaments are tethered to the membranes of extracellular vesicles in Alzheimer’s disease. These findings introduce membrane tethering of amyloid filaments as a potential target to interfere with their accumulation in disease.

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Published on 26th November, 2024

Why do infectious and autoimmune diseases result in joint pain or inflammation?

Tetsuo Hasegawa and Menna Clatworthy, in the University of Cambridge’s Molecular Immunity Unit house at the LMB, studied a synovial knee joint, finding porous capillaries which allow access by circulating immune stimuli, which is in turn policed by a blood-joint barrier of macrophages and nociceptor neurons.

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Published on 25th November, 2024

Whole brain connectome of fruit fly is most complex brain ever mapped

The complete connectome of an adult Drosophila fly - 3D rendering of all ~140k neurons in the fruit fly brain

An international collaboration, including Greg Jefferis’ group in the LMB’s Neurobiology Division, have published the connectome of the Drosophila fly – the most complex brain to be mapped in its entirety, including 140,000 neurons and over 15 million connections.

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Published on 2nd October, 2024
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