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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

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Directional loading mechanism is used by SMC complex to capture and ingest DNA

Led by postdoc Frank Bürmann, Jan Löwe’s group in the LMB’s Structural Studies Division, and Mark Dillingham’s group at the University of Bristol, have identified the mechanism the bacterial SMC complex MukBEF uses to entrap DNA ahead of loop extrusion, and found how this pathway can be inhibited by a bacteriophage protein.

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Published on 31st March, 2025

Writing the LINE-1s: How does LINE-1 remodel human DNA to insert its sequence throughout the genome?

A drawing of two figures standing behind a DNA double helix. The figure in the rear is reading a scroll titled ‘LINE-1’, whilst the figure in the foreground is pulling apart the DNA double helix to glue in a new, red strand labelled ‘LINE-1’. The foreground figure has ‘ORF2p’ written across the chest and a bottle of paste at its feet.

Spearheaded by postdoc George Ghanim, Kelly Nguyen’s group in the LMB’s Structural Studies Division have investigated the molecular mechanisms which allow LINE-1 to propagate throughout the genome via retrotransposition during target-primed reverse transcription.

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Published on 7th March, 2025

Asgard archaea proteins reveal evolutionary secrets of membrane remodelling

Evolution, structure and membrane remodelling function of the ESCRT-III superfamily in eukaryotes and their closest relatives Asgard archaea. The two subfamilies, B-type and A-type, have distinct structural properties to perform sequential steps of the membrane remodelling pathway.

Studying Asgard archaea, Buzz Baum’s group in the LMB’s Cell Biology Division and Aurelien Roux’s group at the University of Geneva, provide insights into the earliest origins of ESCRT-III and reveal how its proteins work together to remodel membranes.

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Published on 11th February, 2025

Newly identified quality control mechanism of RNA Polymerase II transcription

Ana Tufegdžić Vidaković’s group, in the LMB’s PNAC Division, have worked with Scott Berry’s group, at the University of New South Wales, to identify the mechanism cells use to regulate gene expression via control of quality and quantity of Pol II molecules.

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Published on 11th December, 2024

Discovery of a factor that accelerates protein deliveries to the endoplasmic reticulum

Huping Wang and Manu Hegde, in the LMB’s Cell Biology Division, have found a factor that helps nascent secretory and membrane proteins quickly access the protein translocation machinery when they arrive at the endoplasmic reticulum.

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Published on 29th November, 2024

Cryo-ET reveals new molecular insights into tau pathology in Alzheimer’s disease

Benjamin Ryskeldi-Falcon’s group in the LMB’s Neurobiology Division have used cryo-ET to discover that tau filaments are tethered to the membranes of extracellular vesicles in Alzheimer’s disease. These findings introduce membrane tethering of amyloid filaments as a potential target to interfere with their accumulation in disease.

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Published on 26th November, 2024
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