Our publications

    2021

  • Y. Shi, A.G. Murzin, B. Falcon, A. Epstein, J. Machin, P. Tempest, K.L. Newell, R. Vidal, H.J. Garringer, N. Sahara, M. Higuchi, B. Ghetti, M.-K. Jang, S.H.W. Scheres & M. Goedert (2021) "Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607"
    Acta Neuropathologica 141, 697-708
  • S. Lovestam, M. Schweighauser, T. Matsubara, S. Murayama, T. Tomita, T. Ando, K. Hasegawa, M. Yoshida, A. Tarutani, M. Hasegawa, M. Goedert & S.H.W. Scheres (2021) "Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy"
    FEBS OpenBIO 11, 999-1013, bioRxiv 2020.11.27.401364
  • J. Zivanov, T. Nakane & S.H.W. Scheres (2020) "Optical aberrations and Ewald sphere curvature"
    e-book chapter, in press; PDF download
  • T. Nakane & S.H.W. Scheres (2021) "Multi-body refinement of cryo-EM images in RELION"
    Book chapter in Tamir Gonen and Brent L. Nannenga (eds.), CryoEM: Methods and Protocols,
    Methods in Molecular Biology, 2215, 145-160; PDF download
  • D. Kimanius, G. Zickert, T. Nakane, J. Adler, S. Lunz, C.-B. Schonlieb, O. Oktem & S.H.W. Scheres (2021) "Exploiting prior knowledge about biological macromolecules in cryo-EM structure determination"
    IUCrJ 8, 60-75, bioRxiv 2020.03.25.007914
  • M. Goedert, M.G. Spillantini, B. Falcon, W. Zhang, M. Hasegawa, S.H.W. Scheres & B. Ghetti (2021) "Tau protein and frontotemporal dementias. In: 'Frontotemporal dementias - Emerging milestones in the 21st century'"
    Adv. Exp. Med. Biol., 1281
  • 2020

  • M. Kube, F. Kohler, E. Feigl, B. Nagel-Yuksel, E.M. Willner, J.J. Funke, T. Gerling, P. Stommer, M.N. Honemann, T.G. Martin, S.H.W. Scheres & Hendrik Dietz (2020) "Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution"
    Nat. Commun. 11, 6229
  • Z. Ke, J. Oton, K. Qu, M. Cortese, V. Zila, L. McKeane, T. Nakane, J. Zivanov, C.J. Neufeldt, B. Cerikan, J.M. Lu, J. Peukes, X. Xiong, H.G. Krausslich, S.H.W. Scheres, R. Bartenschlager & J.A.G. Briggs (2020) "Structures and distributions of SARS-CoV-2 spike proteins on intact virions"
    Nature, 588, 498-502, bioRxiv 2020.06.27.174979
  • X. Xiong, K. Qu, K.A. Ciazynska, M. Hosmillo, A.P. Carter, S. Ebrahimi, Z. Ke, S.H.W. Scheres, L. Bergamaschi, G.L. Grice, Y. Zhang; CITIID-NIHR COVID-19 BioResource Collaboration, J.A. Nathan, S. Baker, L.C. James, H.E. Baxendale, I. Goodfellow, R. Doffinger & J.A.G. Briggs (2020) "A thermostable, closed SARS-CoV-2 spike protein trimer"
    Nat. Struct. Mol. Biol., 27, 934-941, bioRxiv 2020.06.15.152835
  • T. Nakane, A. Kotecha, A. Sente, G. McMullan, S. Masiulis, P.M.G.E. Brown, I.T. Grigoras, L. Malinauskaite, T. Malinauskas, J. Miehling, T. Uchanski, L. Yu, D. Karia, E.V. Pechnikova, E. de Jong, J. Keizer, M. Bischoff, J. McCormack, P. Tiemeijer, S.W. Hardwick, D.Y. Chirgadze, G. Murshudov, A.R Aricescu & S.H.W. Scheres (2020) "Single-particle cryo-EM at atomic resolution"
    Nature, 587, 152-156, bioRxiv 2020.05.22.110189
  • S.H.W. Scheres, W. Zhang, B. Falcon & M. Goedert (2020) "Cryo-EM structures of tau filaments"
    Curr. Opin. Struct. Biol., 64, 17-25
  • R. Hervas, M.J. Rau, Y. Park, W. Zhang, A.G. Murzin, J.A.J. Fitzpatrick, S.H.W. Scheres & K. Si (2020) "Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila"
    Science 367, 1230-1234
  • M. Schweighauser, Y. Shi, A. Tarutani, F. Kametani, A.G. Murzin, B. Ghetti, T. Matsubara, T. Tomita, T. Ando, K. Hasegawa, S. Murayama, M. Yoshida, M. Hasegawa, S.H.W. Scheres & M. Goedert (2020) "Structures of alpha-synuclein filaments from multiple system atrophy"
    Nature 585, 464-469, bioRxiv 2020.02.05.935619
  • W. Zhang, A. Tarutani, K.L. Newell, A.G. Murzin, T. Matsubara, B. Falcon, R. Vidal, H.J. Garringer, Y. Shi, T. Ikeuchi, S. Murayama, B. Ghetti, M. Hasegawa, M. Goedert & S.H.W. Scheres (2020) "Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathy"
    Nature 580, 283-287, bioRxiv 811703
  • J. Zivanov, T. Nakane & S.H.W. Scheres (2020) "Estimation of high-order aberrations and anisotropic magnification from cryo-EM datasets in RELION-3.1"
    IUCrJ 7, 253-267, bioRxiv 798066
  • S.H.W. Scheres (2020) "Amyloid structure determination in RELION-3.1"
    Acta Cryst. D76, 94-101, bioRxiv 823310
  • 2019

  • S. Shakeel, E. Rajendra, P. Alcon, D. Chorev, F. O'Reilly, G. Deglieposti, S. Maslen, C.J. Russo, S. He, C.H. Hill, M. Skehel, S.H.W. Scheres, J. Rappsilber, C.V. Robinson, & L.A. Passmore (2019) "Structure of the Fanconi anaemia monoubiquitin ligase complex"
    Nature 575, 234-237
  • S.E. Lacey, S. He, S.H.W. Scheres & A.P. Carter (2019) "Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule"
    eLife 8:e47145
  • B. Falcon, J. Zivanov, W. Zhang, A.G. Murzin, H.J. Garringer, R. Vidal, R.A. Crowther, K.L. Newell, B. Ghetti, M. Goedert & S.H.W. Scheres (2019) "Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules"
    Nature 568, 420-423
  • W. Zhang, B. Falcon, A.G. Murzin, J. Fan, R.A. Crowther, M. Goedert & S.H.W. Scheres (2019) "Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's disease"
    eLife 8:e43584, bioRxiv 468892
  • 2018

  • J. Zivanov, T. Nakane, B. Forsberg, D. Kimanius, W.J.H. Hagen, E. Lindahl & S.H.W. Scheres (2018) "RELION-3: new tools for automated high-resolution cryo-EM structure determination"
    eLife 7:e42166, bioRxiv 421123
  • B. Falcon, W. Zhang, M. Schweighauser, A.G. Murzin, R. Vidal, H.J. Garringer, B. Ghetti, S.H.W. Scheres & M. Goedert (2018) "Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold"
    Acta Neuropathologica 136:699-708, bioRxiv 411215
  • J. Zivanov, T. Nakane & S.H.W. Scheres (2018) "A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis"
    IUCr J. 6:5-17, bioRxiv 384537
  • M. Goedert, B. Falcon, W. Zhang, B. Ghetti & S.H.W. Scheres (2018) "Distinct conformers of assembled tau in Alzheimer's and Pick's diseases"
    Cold Spring Harb. Symp. Quant. Biol.83:163-171
  • B. Falcon, W. Zhang, A.G. Murzin, G. Murshudov, H.J. Garringer, R. Vidal, R.A. Crowther, B. Ghetti, S.H.W. Scheres & M. Goedert (2018) "Structures of filaments from Pick's disease reveal a novel tau protein fold"
    Nature 561, 127-140, bioRxiv 302216
  • T. Nakane, D. Kimanius, E. Lindahl & S.H.W. Scheres (2018) "Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION"
    eLife 7:e36861, bioRxiv 286856
  • O. Salih, S. He, S. Planamente, L. Stach, J.T. MacDonald, E. Manoli, S.H.W. Scheres, A. Filloux & P.S. Freemont (2018)
    "Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa"
    Structure 26:329-336
  • 2017

  • C. Gati, A. Stetsenko, D.J. Slotboom, S.H.W. Scheres & A. Guskov (2017) "The structural basis of proton driven zinc transport by ZntB"
    Nat. Commun. 8:1313
  • F.J.D. Alvarez, S. He, J.R. Perilla, S. Jang, K. Schulten, A.N. Engelman, S.H.W. Scheres & P. Zhang (2017) "CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction"
    Science Adv. 3:e1701264
  • S.H.W. Scheres & K. Nagai (2017) "CryoEM structures of spliceosomal complexes reveal the molecular mechanism of pre-mRNA splicing"
    Curr. Opin. Struc. Biol. 46, 130-139
  • A.W.P. Fitzpatrick, B. Falcon, S. He, A.G. Murzin, G. Murshudov, H.J. Garringer, R.A. Crowther, B. Ghetti, M. Goedert & S.H.W. Scheres (2017) "Cryo-EM structures of tau filaments from Alzheimer's disease"
    Nature 547, 185-190
  • A.W.P. Fitzpatrick, S. Llabres, A. Neuberger, J.N. Blaza, X.-C. Bai, U. Okada, S. Murakami, H.W. van Veen, U. Zachariae, S.H.W. Scheres, B.F. Luisi & D. Du (2017) "Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump"
    Nat. Microbiol. 2:17070
  • W. Wong, X.-C. Bai, B.E. Sleebs, T. Triglia, A. Brown, J.K. Thompson, K.E. Jackson, E. Hanssen, D.S. Marapana, I.S. Fernandez, S.A. Ralph, A.F. Cowman, S.H. W. Scheres & J. Baum (2017) "Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis"
    Nat. Microbiol. 2:17031
  • A. Boland, T.G. Martin, Z. Zhang, J. Yang, L. Chang, S.H. W. Scheres & D. Barford (2017) "Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution"
    Nat. Struct. Mol. Biol. 24, 414-418
  • S. He & S.H.W. Scheres (2017) "Helical reconstruction in RELION"
    J. Struct. Biol. 198, 163-176, bioRxiv 095034
  • Y. Li, M. Zhou, Q Hu, X.-C. Bai, W. Huang, S.H.W. Scheres & Y. Shi (2017) "Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme"
    Proc. Natl. Acad. Sci. U S A 114(7), 1542-1547
  • R. Fernandez-Leiro, J. Conrad, J.-C. Yang, S.M.V. Freund, S.H.W. Scheres & M.H. Lamers (2017) "Self-correcting mismatches during high-fidelity DNA replication"
    Nat. Struct. Mol. Biol. 24, 140-143
  • R. Fernandez-Leiro & S.H.W. Scheres (2017) "A pipeline approach to single-particle processing in RELION"
    Acta Cryst. D73, 496-502, bioRxiv 095034
  • 2016

  • D. Kimanius, B.O. Forsberg, S.H.W. Scheres & E. Lindahl (2016) "Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2"
    eLife 5:e18722, bioRxiv 059717
  • T.G. Martin, T.A. Bharat, A.C. Joerger, X.-C. Bai, F. Praetorius, A.R. Fersht, H. Dietz & S.H.W. Scheres (2016) "Design of a molecular support for cryo-EM structure determination"
    Proc. Natl. Acad. Sci. U S A 113(47), E7456-E7463
  • J. Lowe, S. He, S.H.W. Scheres & C.G. Savva (2016) "X-ray and cryo-EM structures of monomeric and filamentous actin-like protein MamK reveal changes associated with polymerization"
    Proc. Natl. Acad. Sci. U S A 113(47), 13396-13401
  • T.A. Bharat & S.H.W. Scheres (2016) "Resolving macromolecular structures from electron cryo-tomography data using subtomogram averaging in RELION."
    Nat. Protoc. 11, 2054-65, bioRxiv 030544
  • R. Fernandez-Leiro & S.H.W. Scheres (2016) "Unravelling biological macromolecules with cryo-electron microscopy"
    Nature 537, 339-346.
  • S.H.W. Scheres (2016) "Processing of Structurally Heterogeneous Cryo-EM Data in RELION"
    Meth. Enzym. 579, 125-157
  • T.H. Nguyen, W.P. Galej, X.-C. Bai, C. Oubridge, A.J. Newman, S.H.W. Scheres & K. Nagai (2016) "Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 A resolution"
    Nature 530, 298-302.
  • 2015

  • X.-C. Bai, E. Rajendra, G. Yang, Y. Shi & S.H.W. Scheres (2015)
    "Sampling the conformational space of the catalytic subunit of human gamma-secretase"
    eLife 3:e11182, bioRxiv 025890
  • R. Fernandez-Leiro, J. Conrad, S.H.W. Scheres & M.H. Lamers (2015) "cryo-EM structures of the E. coli replicative DNA polymerase reveal dynamic interactions with clamp, exonuclease and tau"
    eLife 4:e11134.
  • M. Zhou, Y. Li, Q. Hu, X.-C. Bai, W. Huang, C. Yan, S.H.W. Scheres & Y Shi (2015) "Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1"
    Genes Dev. 29, 2349-61.
  • X.-C. Bai, C. Yan, G. Yang, P. Lu, D. Ma, L. Sun, R. Zhou, S.H.W. Scheres & Y Shi (2015) "An atomic structure of human gamma-secretase"
    Nature 525, 212-217.
  • T.A. Bharat, C.J. Russo, J. Loewe, L.A. Passmore & S.H.W. Scheres (2015) "Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging."
    Structure 23, 1743-1753
  • T.H. Nguyen, W.P. Galey, X.-C. Bai, C.G. Savva, A.J. Newman, S.H.W. Scheres & K. Nagai (2015) "The architecture of the spliceosomal U4/U6.U5 tri-snRNP"
    Nature 253, 47-52.
  • E. Nogales & S.H.W. Scheres (2015) "Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity"
    Mol. Cell 58, 677-689.
  • Y. Pang, X.-C. Bai, C. Yan, Q. Hao, Z. Chen, J.-W. Wang, S.H.W. Scheres & Y Shi (2015) "Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila"
    Genes Dev. 29, 277-287.
  • A. Amunts, A. Brown, J. Toots, S.H.W. Scheres & V. Ramakrishnan (2015) "The structure of the human mitochondrial ribosome"
    Science 348, 95-98.
  • S.H.W. Scheres (2015) "Semi-automated selection of cryo-EM particles in RELION-1.3"
    J. Struc. Biol. 189, 114-122.
  • Z. Yan, X.-C. Bai, C. Yan, J. Wu, Z. Li, T. Xie, W. Peng, C. Yin, X. Li, S.H.W. Scheres, Y. Shi & N. Yan (2015)
    "Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution"
    Nature 517, 50-55.
  • X.-C. Bai, G. McMullan & S.H.W. Scheres (2015) "How cryo-EM is revolutionizing structural biology"
    Trends in Biochemical Sciences 40, 49-57.
  • C. Wood, T. Burnley, A. Patwardhan, S.H.W. Scheres, M. Topf, A. Roseman & M. Winn (2015) "Collaborative computational project for electron cryo-microscopy"
    Acta Cryst. D 71, 123-126.
  • 2014

  • A. Brown, A. Amunts, X.-C. Bai, Y. Sugimoto, P.C. Edwards, G. Murshudov, S.H.W. Scheres & V. Ramakrishnan (2014) "Structure of the large ribosomal subunit from human mitochondria"
    Science 346, 718-722.
  • S.H.W. Scheres (2014) "Beam-induced motion correction for sub-megadalton cryo-EM particles"
    eLife 3:e03665. Comments on this paper: eLife insight.
  • P. Lu, X.-C. Bai, D. Ma, T. Xie, C. Yan, L. Sun, G. Yang, Y. Zhao, R. Zhou, S.H.W. Scheres & Y. Shi (2014) "Three-dimensional structure of human gamma-secretase"
    Nature 512, 166-170. Comments on this paper: Preview in Cell , Faculty of 1000.
  • R.M. Voorhees, I.S. Fernandez, S.H.W. Scheres & R.S. Hegde (2014) "Structure of the mammalian ribosome-Sec61 complex to 3.4 Angstrom resolution"
    Cell 157, 1632-1643. Comments on this paper: Faculty of 1000.
  • W. Wong, X.-C. Bai, A. Brown, I.S. Fernandez, E. Hanssen, M. Condron, Y. Hong Tan, J. Baum & S.H.W. Scheres (2014) "Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine"
    eLife 3:e03080.
  • I.S. Fernandez, X.-C. Bai, G. Murshudov, S.H.W. Scheres & V. Ramakrishnan (2014) "Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome"
    Cell 157, 823-831.
  • A. Amunts, A. Brown, X.-C. Bai, J.L. Llacer, T. Hussain, P. Emsley, F. Long, G. Murshudov, S.H.W. Scheres & V. Ramakrishnan (2014) "Structure of the Yeast Mitochondrial Large Ribosomal Subunit"
    Science 343, 1485-1489. Comments on this paper: Science perspective, Faculty of 1000.
  • 2013

  • I.S. Fernandez, X.-C. Bai, T. Hussain, A.C. Kelley, J.R. Lorsch, V. Ramakrishnan & S.H.W. Scheres (2013) "Molecular architecture of a eukaryotic translational initiation complex"
    Science 342, 6160.
  • S.P. Muench, S.H.W. Scheres, M. Huss, C. Phillips, O. Vitavska, H. Wieczorek, J. Trinick & M.A. Harrison (2013) "Subunit Positioning and Stator Filament Stiffness in Regulation and Power Transmission in the V1 Motor of the Manduca sexta V-ATPase"
    J. Mol. Biol. 426, 286-300.
  • S. Chen, G. McMullan, A.R. Faruqi, G.N. Murshudov, J.M. Short, S.H.W. Scheres & R. Henderson (2013) "High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy"
    Ultramicroscopy 135, 24-35. Comments on this paper: Faculty of 1000.
  • A. Sauerwald, S. Sandin, G. Cristofari, S.H.W. Scheres, J. Lingner & D. Rhodes (2013) "Structure of active dimeric human telomerase"
    Nat. Struct. Mol. Biol. 20, 454-460. Comments on this paper: Faculty of 1000.
  • X.-C. Bai, I.S. Fernandez, G. McMullan & S.H.W. Scheres (2013) "Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles"
    eLife 2:e00461. Comments on this paper: eLife Insight, Nature Methods News & Views, Faculty of 1000.
  • 2012

  • A. Patwardhan, J.M. Carazo, B. Carragher, R. Henderson, J.B. Heymann, E. Hill, G.J. Jensen, I. Lagerstedt, C.L. Lawson, S.J. Ludtke, D. Mastronarde, W.J. Moore, A. Roseman, P. Rosenthal, C.O.S. Sorzano, E. Sanz-Garcia, S.H.W. Scheres, S. Subramaniam, J. Westbrook, M. Winn, J.R. Swedlow & G.J. Kleywegt (2012) "Data management challenges in three-dimensional EM"
    Nat. Struct. Mol. Biol. 19, 1203-1207.
  • X.-C. Bai, T.G. Martin, S.H.W. Scheres & H. Dietz (2012) "Cryo-EM structure of a 3D DNA-origami object"
    Proc. Natl. Acad. Sci. U S A 109, 20012-20017. Comments on this paper: Faculty of 1000.
  • S.H.W. Scheres (2012) "RELION: Implementation of a Bayesian approach to cryo-EM structure determination"
    J. Struc. Biol. 180, 519-530.
  • S.H.W. Scheres & S. Chen (2012) "Prevention of overfitting in cryo-EM structure determination"
    Nat. Methods 9, 853-854.
  • S.H.W. Scheres (2012) "A Bayesian view on cryo-EM structure determination"
    J. Mol. Biol. 415, 406-418.
  • 2010

  • S.H.W. Scheres (2010) "Visualizing molecular machines in action: single-particle analysis with structural variability"
    Advances in Protein Chemistry and Structural Biology 81, 89-119
  • S.H.W. Scheres (2010) "Classification of structural heterogeneity by maximum-likelihood methods"
    Meth. Enzym. 482, 295-320.
  • F.J. Sigworth, P. Doerschuk, J.M. Carazo & S.H.W. Scheres (2010) "An introduction to maximum-likelihood methods in cryo-EM"
    Meth. Enzym. 482, 263-294.
  • pre-LMB

  • R. Melero, S. Rajagopalan, M. Lazaro, A.C. Joerger, T. Brandt, D.B. Veprintsev, G. Lasso, D. Gil, S.H.W. Scheres, J.M. Carazo, A.R. Fersht & M. Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA"
    Proc. Natl. Acad. Sci. U S A 108, 557-562
  • M. Stolken, F. Beck, T. Haller, R. Hegerl, I. Gutsche, J.M. Carazo, W. Baumeister, S.H.W. Scheres & S. Nickell (2011) "Maximum Likelihood based Classification of Electron Tomographic Data"
    J. Struc. Biol. 173, 77-85.
  • J.O. Ortiz, F. Brandt, V.R.F. Matias, L. Sennels, J. Rappsilber, S.H.W. Scheres, M. Eibauer, F.U. Hartl & W. Baumeister (2010) "Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ"
    J. Cell. Biol. 190, 613-621. Comments on this paper: Faculty of 1000
  • I. Cuesta, R. Nunez-Ramirez, S.H.W. Scheres, D. Gai, X. Chen, E. Fanning. & J.M. Carazo (2010) "Conformational rearrangements of SV40 large-T antigen during early replication events"
    J. Mol. Biol. 397, 1276-1286
  • K. Cheng, N. Ivanova, S.H.W. Scheres, M.Y. Pavlov, J.M. Carazo, H. Hebert, M. Ehrenberg & Martin Lindahl (2010) "tmRNA-SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes"
    J. Struc. Biol. 169, 342-348
  • S.H.W. Scheres, R.M. Melero, M. Valle & J.M. Carazo (2009) "Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization"
    Structure 17, 1563-1572
  • M.A. Recuero-Checa, A.S. Dore, E. Arias-Palomo, A. Rivera-Calzada, S.H.W. Scheres, J.D. Maman, L.H. Pearl & O. Llorca (2009) "Electron Microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex"
    DNA Repair 8, 1380-1389
  • A.J. Perez-Berna, R. Marabini, S.H.W. Scheres, R. Menendez-Conejero, I.P. Dmitriev, D.T. Curiel, W.F. Mangel, S.J. Flint & C. San Martin (2009) "Structure and uncoating of immature adenovirus"
    J. Mol. Biol. 292, 547-557
  • S. Nickell, F. Beck, S.H.W. Scheres, A. Korinek, F. Foerster, K. Lasker, O. Mihalache, N. Sun, I. Nagy, A. Sali, J.M. Plitzko, J.M. Carazo, M. Mann & W. Baumeister (2009) "New insights into the molecular architecture of the 26S proteasome"
    Proc. Natl. Acad. Sci. U S A 106, 11943-11947
  • S.H.W. Scheres, & J.M. Carazo (2009) "Introducing robustness to maximum likelihood refinement of electron microscopy data"
    Acta Cryst. D65, 672-678
  • S.H.W. Scheres, M. Valle, P. Grob, E. Nogales & J.M. Carazo (2009) "Maximum likelihood refinement of electron microscopy data with normalization errors"
    J. Struc. Biol. 166, 234-240
  • P. Julian, A.L. Konevega, S.H.W. Scheres, M. Lazaro, D. Gil, W. Wintermeyer, M.V. Rodnina & M. Valle (2008) "Structure of Ratcheted Ribosomes with tRNAs in Hybrid States"
    Proc. Natl. Acad. Sci. U S A 105, 16924-16927
  • J. Cuellar, J. Martin-Benito, S.H.W. Scheres, R. Sousa, F. Moro, E. Lopez-Viñas, P. Gomez-Puertas, A. Muga, J.L. Carrascosa & J.M. Valpuesta (2008) "The structure of a CCT:Hsc70NBD complex suggests a mechanism for Hsp70 delivery of substrates to the chaperonin"
    Nat. Struct. Mol. Biol. 15, 858-864. Comments on this paper: Faculty of 1000
  • S.H.W. Scheres, G.T. Herman & J.M. Carazo (2008) PDF
    "Exploring the conformational flexibility of macromolecular machines"
    Mathematical Methods in Biomedical Imaging and Intensity-Modulated Radiation Therapy (IMRT)
    Y. Censor, M. Jiang and A.K. Louis (Editors), Edizioni della Normale, Pisa, Italy, 349-365
  • S.H.W. Scheres, R. Nuñez-Ramirez, C.O.S. Sorzano, J.M. Carazo & R. Marabini (2008) "Image processing for electron microscopy single-particle analysis using Xmipp"
    Nat. Protoc. 3, 977-990
  • S.H.W. Scheres, R. Nuñez-Ramirez, Y. Gomez-Llorente, C. San Martin, P.P.B. Eggermont & J.M. Carazo (2007) "Modelling experimental image formation for likelihood-based classification of electron microscopy data"
    Structure 15, 1167-1177
  • X. Agirrezabala, J.A. Velazquez-Muriel, P. Gomez-Puertas, S.H.W. Scheres, J.M. Carazo & J.L. Carrascosa (2007) "Quasi-atomic model of bacteriophage T7 procapsid shell: insights into the structure and evolution of a basic fold"
    Structure 15, 461-472
  • S.H.W. Scheres, H. Gao, M. Valle, G.T. Herman, P.P.B. Eggermont, J. Frank & J.M. Carazo (2007) "Disentangling Conformational States of Macromolecules in 3D-EM through Likelihood Optimization"
    Nat. Methods 4, 27-29. Comments on this paper: News & Views Nature Methods, Faculty of 1000
  • C.O.S. Sorzano, R. Marabini, A. Pascual-Montano, S.H.W. Scheres & J.M. Carazo (2006) "Optimization problems in electron microscopy of single particles"
    Annals of Operations Research 148(1), 133-165
  • S.H.W. Scheres, M. Valle & J.M. Carazo (2005) "Fast maximum-likelihood refinement of electron microscopy images"
    Bioinformatics 21 (Suppl. 2), ii243-ii244
  • S.H.W. Scheres, A.J. Merino, C.O.S. Sorzano & J.M. Carazo (2005) "Grid Computing in 3D-EM Image Processing Using Xmipp"
    18th IEEE Symposium on Computer-Based Medical Systems pp. 561-563
  • S.H.W. Scheres, R. Marabini, S. Lanzavecchia, F. Cantele, T. Rutten, S.D. Fuller, J.M. Carazo, R.M. Burnett & C. San Martin (2005) "Classification of single projection reconstructions for cryo-electron microscopy data of icosahedral viruses"
    J. Struc. Biol. 151(1), 79-91
  • S.H.W. Scheres, M. Valle, R. Nuñez, R. Marabini, C.O.S. Sorzano, G.T. Herman & J.M. Carazo (2005) "Maximum-likelihood multi-reference refinement for electron microscopy images"
    J. Mol. Biol. 348(1), 139-149
  • J. Velázquez-Muriel, C.O.S. Sorzano, S.H.W. Scheres & J.M. Carazo (2005) "SPI-EM: Towards a tool for predicting CATH superfamilies in 3D-EM maps"
    J. Mol. Biol. 345(4), 759-771
  • S.H.W. Scheres< & P. Gros (2004) "The potentials of conditional optimization in phasing and model building of protein-structures"
    Acta Cryst. D60, 2202-2209
  • C.O.S. Sorzano, R. Marabini, J. Velázquez-Muriel, J.R. Bilbao-Castro, S.H.W. Scheres, J.M. Carazo & A. Pascual-Montano (2004) "XMIPP: a new generation of an open-source image processing package for Electron Microscopy"
    J. Struc. Biol. 148(2), 194-204
  • S.H.W. Scheres & P. Gros (2003) "Development of a force field for conditional optimization of protein structures"
    Acta Cryst. D59, 483-446
  • S.H.W. Scheres & P. Gros (2001) "Conditional optimization: a new formalism for protein structure refinement"
    Acta Cryst. D57, 1820-1828
  • R.B.G. Ravelli, M.L. Raves, S.H.W. Scheres, A. Schouten & J. Kroon (1999) "Ab initio structure determination of low-molecular-weight compounds using Laue synchrotron radiation Laue diffraction"
    J. Synchrotron Rad.
    6, 19-28