Publications

Carrara, M., Sigurdardottir, A., & Bertolotti, A. (2017).
Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors.
Nat Struct Mol Biol, 24(9), 708–716. https://doi.org/10.1038/nsmb.3443

Adrien Rousseau, Anne Bertolotti, (2016).
An evolutionarily conserved pathway controls proteasome homeostasis.
Nature doi: 10.1038/nature18943. [Epub ahead of print]

Paper in Nature and pdf
Nature News & Views

Indrajit Das, Agnieszka Krzyzosiak, Kim Schneider, Lawrence Wrabetz, Maurizio D’Antonio, Nicholas Barry, Anna Sigurdardottir, Anne Bertolotti, (2015).
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
Science 348 no. 6231 pp. 239-242.

Ariane Hanssum, Zhen Zhong, Adrien Rousseau, Agnieszka Krzyzosiak, Anna Sigurdardottir, Anne Bertolotti. (2014).
An Inducible Chaperone Adapts Proteasome Assembly to Stress.
Mol. Cell. 55, 566–577.

Suraweera, A., Munch, C., Hanssum, A., and Bertolotti, A. (2012).
Failure of amino acid homeostasis causes cell death following proteasome inhibition.
Mol. Cell. 48, 242–253.

Editor’s Choice. Science. (2012). 337. 1584.
In Brief. Nat. Rev. Mo.l Cell. Biol. (2012). 13. 685
Research Highlights. Nat. Chem. Biol. (2012). 8. 873.
recommended by Faculty of 1000.

Moreno, J.A., Radford, H., Peretti, D., Steinert, J.R., Verity, N., Martin, M.G., Halliday, M., Morgan, J., Dinsdale, D., Ortori, C.A., Barrett D. A., Tsaytler P., Bertolotti A., Willis A.E., M. Bushell, and G R Mallucci (2012).
Sustained translational repression by eIF2alpha-P mediates prion neurodegeneration.
Nature. 485, 507–511.

Tsaytler, P., Harding, H. P., Ron, D., and Bertolotti. (2011).
A. Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis.
Science 332, 91-94.

Comment in Science. 2011 Apr 1;332(6025):44-5.
recommended by Faculty of 1000.
Editor’s Choice. (2011). Sci. STKE. 4 (167). ec98

Munch, C., O'Brien, J., and Bertolotti, A. (2011).
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells.
Proc Natl Acad Sci U S A 108, 3548-3553.

Munch, C., and Bertolotti, A. (2010).
Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants.
J Mol Biol 399, 512-525.

Rousseau, E, Kojima, R, Hoffner, G, Djian, P and Bertolotti, A. (2009)
Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones.
JBC. 284 (3): p1917-29

Dehay, B., Weber, C., Trottier, Y., and Bertolotti, A. (2007).
Mapping of the epitope of monoclonal antibody 2B4 to the proline-rich region of human Huntingtin, a region critical for aggregation and toxicity.
Biotechnol J. 2(5): 559-64

Dehay, B and Bertolotti, A. (2006)
Critical Role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast.
JBC. 2006. 281, 35608-35615.

Rousseau, E., Dehay, B., Ben-Haïem, L., Trottier, Y., Morange, M. and Bertolotti, A. (2004)
Targeting expression of expanded polyglutamine proteins to the endoplasmic reticulum or mitochondria prevents their aggregation.
PNAS. 2004. 101(26): 9648-53.

Research Highlights, Assisted aggregation, Nat Struct Mol Biol. 2004 Aug;11(8):696

Marcu, M.G., Doyle, M., Bertolotti, A., Ron, D. Hendershot, L., Neckers, L. et al. (2002)
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
Mol Cell Biol, 2002. 22(24): p. 8506-13.

Bertolotti, A., and Ron, D. (2001)
Alterations in an IRE1-RNA complex in the mammalian unfolded protein response.
J Cell Sci. 2001. 114:3207-3212

Bertolotti A, Wang XZ, Novoa I, Jungreis R, Schlessinger K, Cho J. H, West A.B and Ron D. (2001)
Increased sensitivity to dextran sodium sulfate colitis in IRE1b deficient mice.
J. Clin. Invest. 2001 March 107:585-593

Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. (2000)
Perk is essential for translational regulation and cell survival during the unfolded protein response.
Mol Cell 2000 May;5(5):897-904

Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. (2000)
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response.
Nature Cell Biol 2000 Jun;2(6):326-32

Editors' choice, Science, 2000 May 26 ; 288 (5470) :1302.

Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. (2000)
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
Science 2000 Jan 28;287(5453):664-6

Bertolotti A, Bell B, Tora L. (1999)
The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties.
Oncogene 1999 Dec 23;18(56):8000-10

Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L. (1997)
EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes.
Mol Cell Biol 1998 Mar;18(3):1489-97

Bertolotti A, Lutz Y, Heard DJ, Chambon P, Tora L. (1996)
hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.
EMBO J 1996 Sep 16;15(18):5022-31

Review articles

Tsaytler, P., and Bertolotti, A. (2013).
Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention.
FEBS J. 280 (2). 766-770.

Münch, C., and Bertolotti, A. (2012).
Propagation of the prion phenomenon: beyond the seeding principle.
J. Mol. Biol. 421, 491–498.

Münch, C., and Bertolotti, A. (2011).
Self-propagation and transmission of misfolded mutant SOD1: Prion or prion-like phenomenon?
Cell Cycle 10, 1711.

Bertolotti, A. (2008).
Protein misfolding in neurodegenerative diseases.
Dementia Forum 5, 17–20.

Bertolotti A. (2011).
Glucose levels are partly regulated through the alteration of protein synthesis induction.
Med. Sci. 10 :1086-1087

Harding, H.P., Novoa, I., Bertolotti, A., Zeng, H., Zhang, Y., Urano, F., Jousse, C., and Ron, D. (2001).
Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.
Cold Spring Harb. Symp. Quant. Biol. 66, 499–508.

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