Welcome to the Scheres lab

We are intrigued by how molecular machines perform their complicated tasks in the living cell. Just like machines invented by humans, molecular machines use movements of separate parts in their functioning. For example, we find it amazing that rotations of protein molecules (ATP synthase) are used in the nano-scale equivalent of water mills to provide enegy for the cell. We are also fascinated how, in disease, proteins may unfold to adopt filamentous structures called amyloids. For example, amyloid formation of amyloid-beta and tau are the hallmark of Alzheimer's disease.

We are interested in methods that allow visualising these macromolecules in their multitude of natural states, as well as their amyloid forms. One line of work focusses on developing powerful computer algorithms to determine atomic structures of biological macromolecules from electron cryo-microscopy (cryo-EM) images. In a second line of work, we use our own methods to determine the structures of amyloids that are extracted from the brains of individuals with neurodegenerative diseases, like Alzheimer's and Pick's disease.

Please browse through these pages to learn more about our research, and how it contributes to a better understanding of the functioning of molecular machines.

Contact

scheres@mrc-lmb.cam.ac.uk

Sjors Scheres
MRC Laboratory of Molecular Biology
Room 2N006
Francis Crick Avenue
Cambridge Biomedical Campus
CB2 0QH, Cambridge
United Kingdom
tel: +44 (0)1223 267061