Andriko von Kügelgen

I studied biochemistry in Tübingen after which I moved to the University of Oxford where I joined Tanmay Bharat’s lab for my PhD. During my PhD studies I investigated archaeal and bacterial cell surface proteins using cryo electron tomography and subtomogram averaging.

I am interested in studying the interactions of archaea and bacteria in complex microbial communities within biofilms.

Publications

von Kügelgen, A., Tang, H., Hardy, G.G., Kureisaite-Ciziene, D., Brun, Y.V., Stansfeld, P.J., Robinson, C.V., and Bharat, T.A.M., “In Situ Structure of an Intact Lipopolysaccharide-Bound Bacterial Surface Layer”. Cell, (2020). 180(2): p. 348-358 e15.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978808/

von Kügelgen, A., Alva, V., and Bharat, T.A.M., “Complete atomic structure of a native archaeal cell surface”. Cell Reports, (2021). 37(8): p. 110052.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640222/

Herdman, M.*, von Kügelgen, A.*, Kureisaite-Ciziene, D., Duman, R., El Omari, K., Garman, E.F., Kjaer, A., Kolokouris, D., Lowe, J., Wagner, A., Stansfeld, P.J., and Bharat, T.A.M., “High-resolution mapping of metal ions reveals principles of surface layer assembly in Caulobacter crescentus cells”. Structure, (2022). 30(2): p. 215-228 e5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828063/

von Kügelgen, A., van Dorst, S., Alva, V., and Bharat, T.A.M., “A multidomain connector links the outer membrane and cell wall in phylogenetically deep-branching bacteria”. PNAS, (2022). 119(33): p. e2203156119.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388160/

von Kügelgen, A., van Dorst, S., Yamashita, K., Sexton, D.L., Tocheva, E.I., Murshudov, G., Alva, V., and Bharat, T.A.M., “Interdigitated immunoglobulin arrays form the hyperstable surface layer of the extremophilic bacterium Deinococcus radiodurans”. PNAS, (2023). 120(16): p. e2215808120.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120038/