Publications

Notes: * co-first authors; # co-corresponding authors

2024

• Lewis, A.J.O., Zhong, F., Keenan, R.J., Hegde, R.S. (2024) Structural analysis of the dynamic ribosome-translocon complex. eLife, 13:RP95814.
• Hegde, R.S. and Keenan, R.J. (2024) A unifying model for membrane protein biogenesis. Nat. Struct. Mol. Biol., 31:1009-1017.
• Hegde, R.S. (2024) Getting membrane proteins into shape. Mol. Cell, 84:1821-1823.
• Hegde, R.S. (2024) How to enjoy and thrive in graduate school. Trends Cell Biol., 34:349-351.
• Hegde, R.S. (2024) Things you should learn in graduate school. Trends Cell Biol., 34:269-271.
• Wu, H., Smalinskaite, L., Hegde, R.S. (2024) EMC rectifies the topology of multipass membrane proteins. Nat. Struct. Mol. Biol., 31:32-41.

2023

• Höpfler, M. and Hegde, R.S. (2023) Control of mRNA fate by its encoded nascent polypeptide. Mol. Cell, 83:2840-2855.
• Yagita, Y., Zavodszky, E., Peak-Chew, S.Y., and Hegde, R.S. (2023) Mechanism of orphan subunit recognition during assembly quality control. Cell, 186:3443-3459.
• Höpfler, M., Absmeier, E., Peak-Chew, S.Y., Vartholomaiou, E., Passmore, L.A., Gasic, I., Hegde, R.S. (2023) Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation. Mol. Cell, 83:2290-2302.
• Lemus, L., Hegde, R.S., Goder, V. (2023) New frontiers in quality control: the case of GPI-anchored proteins. Nat. Rev. Mol. Cell Biol., doi: 10.1038/s41580-023-00616-9.
• Wu, H. and Hegde, R.S. (2023) Mechanism of signal-anchor triage during early steps of membrane protein insertion. Mol. Cell, 83:961-973.
• Smalinskaitė, L. and Hegde, R.S. (2023) The biogenesis of multipass membrane proteins. Cold Spring Harb. Perspect Biol., 15: a041251.

2022

• ^*Smalinskaitė, L., ^*Kim, M.K., Lewis, A.J.O., Keenan, R.J., and Hegde, R.S. (2022) Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611:161-166.
• ^*Sundaram, A., ^*Yamsek, M., ^*Zhong, F., Hooda, Y., Hegde, R.S., Keenan, R.J. (2022) Substrate-driven assembly of a translocon for multipass protein biosynthesis. Nature, 611:167-172.
• Hegde, R.S. (2022) The function, structure, and origins of the ER membrane protein complex. Annu. Rev. Biochem., 91:651-678.
• Neal, S., Ohtake, F., Cuervo, A.M., Hegde R.S., Jakob, U., Lazarou, M., Gilbert, W.V., Chen, Z.J., Tooze, S.A., Haber, J.E., Walters, K.J., and Hartl, F.U. (2022) Quality Control: Maintaining molecular order and preventing cellular chaos. Mol. Cell, 82:1390-1397.
• ^*Jomaa, A., ^*Gamerdinger, M., ^*Hsieh, H.H., Wallisch, A., Chandrasekaran, V., Ulusoy, Z., Scaiola, A., Hegde, R.S., Shan, S.O., Ban, N., and Deuerling, E. (2022) Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science, 375:839-844.
• Hegde, R.S. and Keenan, R.J. (2022) The mechanisms of integral membrane protein biogenesis. Nat. Rev. Mol. Cell Biol., 23:107-124.

2021

• Lewis, A.J.O. and Hegde, R.S. (2021) A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC. BMC Biol., 19:266
• Zavodszky, E., Peak-Chew, S.-Y., Juszkiewicz, S., Narvaez, A.J. and Hegde, R.S. (2021) Identification of a quality-control factor that monitors failures during proteasome assembly. Science, 373, 998-1004.
• Wan, L., Juszkiewicz, S., Blears, D., Bajpe, P.K., Han, Z., Faull, P., Mitter, R., Stewart, A., Snijders, A.P., Hegde, R.S., and Svejstrup, J.Q. (2021) Translation stress and collided ribosomes are co-activators of cGAS. Mol. Cell, 81, 2808-2822.

2020

• Chitwood, P. and Hegde, R.S. (2020) An intramembrane chaperone complex facilitates membrane protein biogenesis. Nature, 584, 630-634.
• Juszkiewicz, S., Slodkowicz, G., Lin, Z., Freire-Pritchett, P., Peak-Chew, S.Y., and Hegde, R.S. (2020) Ribosome collisions trigger cis-acting feedback inhibition of translation initiation. eLife, doi: 10.7554/eLife.60038.
• Juszkiewicz, S., Speldewinde, S.H., Wan, L., Svejstrup, J.Q., and Hegde, R.S. (2020) The ASC-1 complex disassembles collided ribosomes. Mol. Cell, doi: 10.1016/j.molcel.2020.06.006.
• *O’Donnell, J.P., *Phillips, B.P., *Yagita, Y., Juszkiewicz, S., Wagner, A., Malinverni, D., Keenan, R.J., Miller, E.A., and Hegde, R.S. (2020) The architecture of EMC reveals a path for membrane protein insertion. eLife, doi: 10.7554/eLife.57887.

2019

• *Chandrasekaran, V., *Juszkiewicz, S., Choi, J., Puglisi, J.D., Brown, A., Shao, S., Ramakrishnan, V., and Hegde, R.S. (2019) Mechanism of ribosome stalling during translation of a poly(A) tail. Nat. Struct. Mol. Biol., doi: 10.1038/s41594-019-0331-x.
• Lin, Z., Gasic, I., Chandrasekaran, V., Peters, N., Shao, S., Mitchison, T.J., and Hegde, R.S. (2019) TTC5 mediates autoregulation of tubulin via mRNA degradation. Science, doi: 10.1126/science.aaz4352.
• Verhagen, J.M.A. et al. (2019) Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy. Circ. Genome Precision Med., 12:397-406.
• Zavodszky, E. and Hegde, R.S. (2019) Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors. eLife, 8:e46740.
• Hegde, R.S. and Zavodszky, E. (2019) Recognition and Degradation of Mislocalized Proteins in Health and Disease.. Cold Spring Harb Perspect Biol. doi: 10.1101/cshperspect.a033902
• Chitwood, P.J. and Hegde, R.S. (2019) The Role of EMC during Membrane Protein Biogenesis.. Trends Cell Biol. doi:10.1016/j.tcb.2019.01.007
• Inglis, A.J., Masson, G.R., Shao, S., Perisic, O., McLaughlin, S.H., Hegde, R.S., and Williams, R.L. (2019) Activation of GCN2 by the ribosomal P-stalk.. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1813352116
• Volkmar, N., Thezenas, M.-L., Louie, S.M., Juszkiewicz, S., Nomura, D.K., Hegde, R.S., Kessler, B.M., and Christianson, J.C. (2019) The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. J. Cell Sci. doi:10.1242/jcs.223453

2018

• Chitwood, P.J., Juszkiewicz, S., Guna, A., Shao, S., and Hegde, R.S. (2018) EMC is required to initiate accurate membrane protein topogenesis. Cell 175:1507-1519.
• *Juszkiewicz, S., *#Chandrasekaran, V., Lin, Z., Kraaz, S., Ramakrishnan, V., and Hegde, R.S. (2018) ZNF598 is a quality control sensor of ribosome collisions. Mol. Cell 72:469-481
• Juszkiewicz, S. and Hegde, R.S. (2018) Quality control of orphaned proteins. Mol. Cell 71:443-457.
• Guna, A. and Hegde, R.S. (2018) Transmembrane domain recognition during membrane protein biogenesis and quality control. Current Biology 28:R498-R511.
• Guna, A., Volkmar, N., Christianson, J.C. and Hegde, R.S. (2018) The ER membrane protein complex is a transmembrane domain insertase. Science 359:470-473.

2017

• Anghel, S.A., McGilvray, P.T., Hegde, R.S. and Keenan, R.J. (2017) Identification of Oxa1 homologs operating in the eukaryotic endoplasmic reticulum. Cell Reports 21:3708-3716.
• Yanagitani, K., Juszkiewicz, S., and Hegde, R.S. (2017) UBE2O is a quality control factor for orphans of multi-protein complexes. Science 357: 472-475.
• Shao, S., Rodrigo-Brenni, M.C., Kivlen, M.H., and Hegde, R.S. (2017) Mechanistic basis for a molecular triage reaction. Science, 355(6322):298-302.
• Chen, C., Itakura, E., Nelson, G.M., Sheng, M., Laurent, P., Hegde, R.S., and de Bono, M. (2017) IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature, doi:10.1038/nature20818.
• Juszkiewicz, S. and Hegde, R.S. (2017) Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. Mol. Cell, doi:10.1016/j.molcel.2016.11.039.

2016

• Shao, S., Murray, J., Brown, A., Taunton, J., ^#Ramakrishnan, V., and ^#Hegde, R.S. (2016) Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell, 167(5):1229-1240.
• Itakura, E., Zavodszky, E., Shao, S., Wohlever, M.L., Keenan, R.J., and Hegde, R.S. (2016) Ubiquilins chaperone and triage mitochondrial membrane proteins for degradation. Mol. Cell, 63(1):21-33.
• Brandman, O. and Hegde, R.S. (2016) Ribosome-associated protein quality control. Nat Struct Mol Biol, 23(1):7-15.
• Voorhees, R.M. and Hegde, R.S. (2016) Structure of the Sec61 channel opened by a signal sequence. Science, 351(6268):88-91.
• Shao, S. and Hegde, R. S. (2016) Target Selection during Protein Quality Control. Trends Biochem, 41(2):124-37.

2015

• Brown, A., ^*Shao, S., Murray, J., ^#Hegde, R. S., and ^#Ramakrishnan, V. (2015) Structural basis for stop codon recognition in eukaryotes. Nature, 524:493-6.
• Voorhees, R.M., and Hegde, R.S. (2015) Structures of the scanning and engaged states of the mammalian SRP-ribosome complex. Elife, 4:e07975.
• von der Malsburg, K., Shao, S., and Hegde, R.S. (2015) The Ribosome Quality Control Pathway can Access Nascent Polypeptides Stalled at the Sec61 Translocon. Mol Biol Cell, 26:2168-80.
• Mateja, A. Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., ^#Hegde, R.S., and ^#Keenan, R.J. (2015) Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science, 347:1152-5.
• Shao, S., Brown, A., Santhanam, B., and Hegde, R.S. (2015) Structure and assembly pathway of the ribosome quality control complex. Mol. Cell, 57:433-44.

2014

• Shao, S. and Hegde, R.S. (2014) Local synthesis and disposal. Science, 346:701-2.
• Shao, S. and Hegde, R.S. (2014) Reconstitution of a Minimal Ribosome-Associated Ubiquitination Pathway with Purified Factors. Mol. Cell, 55:880-90.
• Satpute-Krishnan, P., Ajinkya, M., Bhat, S., Itakura, E., ^#Hegde R.S., and ^#Lippincott-Schwartz, J. (2014) ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway. Cell, 158:522-533
• ^*#Voorhees, R.M., ^*Fernandez, I.S., Scheres, S.H.W., and ^#Hegde, R.S. (2014) Structure of the mammalian-Sec61 complex to 3.4  resolution. Cell, 157:1632-43.
• Hegde, R.S. (2014) Msp1: patrolling mitochondria for lost proteins. EMBO J, 33:1509-10.
• Rodrigo-Brenni, M.C., Gutierrez, E., and Hegde, R.S. (2014) Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. Mol. Cell, 55:227-237.
• Chen, C., Itakura, E., Weber, K.P., Hegde, R.S., and de Bono, M. (2014) An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism. PLoS Genetics, 10(3):e1004082.
• ^*MacKinnon, A.L., ^*Paavilainen, V.O., Sharma, A., Hegde, R.S., and Taunton, J. (2014) An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate. eLife, 3:e01483.

2013

• Zhang, Z.R., Bonifacino, J.S., and Hegde, R.S. (2013) Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER. Cell, 154, 609-22.
• ^*Shao, S., ^*von der Malsburg, K., and Hegde, R.S. (2013) Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation. Mol. Cell 50:637-48.

2012

• Rodrigo-Brenni, M.C. and Hegde, R.S. (2012) Design principles of protein biosynthesis-coupled quality control. Dev. Cell, 23:896-907.
• Basseville, A., Tamaki, A., Ierano, C., Trostel, S., Ward, Y., Robey, R.W., Hegde, R.S., and Bates, S.E. (2012) Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter. Cancer Res. 72:3642-51.

2011

• Shao, S. and Hegde, R.S. (2011) A calmodulin-dependent translocation pathway for small secretory proteins. Cell 147:1576-88.
• Hegde, R.S. and Keenan, R.J. (2011) Tail-anchored membrane protein insertion into the endoplasmic reticulum. Nat. Rev. Mol. Cell Biol. 12:787-98.
• Maifeld, S.V., MacKinnon, A.L., Garrison, J.L., Sharma, A., Hegde, R.S., Kunkel, E.J., and Taunton, J. (2011) Secretory protein profiling reveals TNF_ inactivation by selective and promiscuous Sec61 modulators. Chem. Biol., 18:1082-8.
• Shao, S. and Hegde, R.S. (2011) Membrane protein insertion at the endoplasmic reticulum. Ann. Rev. Cell Dev. Biol., 27:25-56.
• ^*Mariappan, M., ^*Mateja, A., Dobosz, M., Bove, E., ^#Hegde, R.S., and ^#Keenan, R.J. (2011) The mechanism of membrane-associated steps in tail-anchored protein insertion. Nature 477:61-6.
• Hessa, T., Sharma, A., Mariappan, M., Eshleman, H.D., Gutierrez, E., and Hegde, R.S. (2011) Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature, 475:394-7.
• Wang, Q., Liu, Y., Soetandyo, N., Baek, K., Hegde, R.S., and Ye, Y. (2011) A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasomal degradation. Mol. Cell 42:758-70.
• Shao, S. and Hegde, R.S. (2011) A flip turn for membrane protein insertion. Cell, 146:13-15.
• Sherrill, J., Mariappan, M., Dominik, P., Hegde, R.S., and Keenan, R.J. (2011) A conserved archaeal pathway for tail-anchored membrane protein insertion. Traffic, doi: 10.1111/j.1600-0854.2011.01229.x.
• Chakrabarti, O., Rane, N.S., and Hegde, R.S. (2011) Cytosolic aggregates perturb the degradation of non-translocated secretory and membrane proteins. Mol. Biol. Cell, 22:1625-37.
• Morimoto, R.I., Driessen, A.J., Hegde, R.S., and Langer, T. (2011) The life of proteins: the good, the mostly good and the ugly. Nat. Struct. Mol. Biol. 18:1-4.

2010

• Emerman, A.E., Zhang, Z.R., Chakrabarti, O., and Hegde, R.S. (2010) Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo. Mol. Biol. Cell 21:4325-37.
• Mariappan, M., Li, X., Sharma, A., Mateja, A., Keenan, R.J., and Hegde, R.S. (2010) A ribosome-associating factor chaperones tail-anchored membrane proteins. Nature, 466:1120-4.
• Hegde, R.S. and Ploegh, H.L. (2010) Quality and Quantity Control at the Endoplasmic Reticulum. Curr. Opin. Cell Biol. 10.1016/j.ceb.2010.05.005.
• Rutkowski, D.T. and Hegde, R.S. (2010) Regulation of basal cellular physiology by the homeostatic unfolded protein response. J. Cell Biol. 189:783-94.
• Rane, N.S., Chakrabarti, O., Feigenbaum, L., and Hegde, R.S. (2010) Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein. J. Cell Biol. 188:515-26.
• Sharma, A.S., Mariappan, M., Appathurai, S., and Hegde, R.S. (2010) In vitro dissection of protein translocation into the mammalian endoplasmic reticulum. Methods Mol. Biol. 619:339-63.

2009

• Mateja, A., Szlachcic, A., Downing, M.E., Dobosz, M., Mariappan, M., Hegde, R.S., and Keenan, R.J. (2009) The structural basis of tail-anchored membrane protein recognition by Get3. Nature, 461:361-6.
• Ashok, A. and Hegde, R.S. (2009) Selective Processing and Metabolism of Disease-Causing Mutant Prion Proteins. PLoS Pathogens, 5:e1000479.
• Chakrabarti, O. and Hegde, R.S. (2009) Functional depletion of Mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. Cell, 137:1136-1147.
• Chakrabarti, O., Ashok, A., and Hegde, R.S. (2009) Prion protein biosynthesis and its emerging role in neurodegeneration. Trends Biochem. Sci., 34:287-95.
• Hegde, R.S. (2009) Protein maturation and processing at the endoplasmic reticulum. In: The Liver: Biology and Pathobiology. 5^th Edition. Edited by I. A. Arias et al., Wiley-Blackwell.
• Polgar, O., Ediriwickrema, L.S., Robey, R.W., Sharma, A., Hegde, R.S., Li, Y., Xia, D., Ward, Y., Dean, M., Ozvegy-Laczka, C., Sarkadi, B., and Bates, S.E. (2009) Arginine 383 is a crucial residue in ABCG2 biogenesis. Biochim. Biophy. Acta, 1788(7):1434-43.
• Kang, S.W. and Hegde, R.S. (2008) Lighting up the stressed ER. Cell, 135(5):787-9.

2008

• Rane, N.S., Kang, S.W., Chakrabarti, O., Feigenbaum, L., and Hegde, R.S. (2008) Chronic prion protein degradation via pre-emptive quality control causes neurodegeneration. Dev. Cell, 15:359-370.
• Hegde, R.S. and Kang, S.W. (2008) The concept of translocational regulation. J. Cell Biol. 182:225-232.
• Menetret, J.F., Hegde, R.S., Aguiar, M., Gygi, S.P., Park, E., Rapoport, T.A., and Akey, C.W. (2008) Single copies of Sec61 and TRAP associate with a non-translating mammalian ribosome. Structure, 16:1126-1137.
• Ashok, A. and Hegde, R.S. (2008) Retrotranslocation of prion proteins from the ER by inhibition of GPI signal sequence transamidation. Mol. Biol. Cell. 19:3463-3476.
• Ashok, A. and Hegde, R.S. (2008) Cytotoxicity of aberrant proteins. In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd: DOI: 10.1002/9780470015902.a0020887.

2007

• MacKinnon, A.L., Garrison, J.L., Hegde, R.S., and Taunton J. (2007) Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J. Am. Chem. Soc. 129:14560-1.
• ^*Rutkowski, D.T., ^*Kang, S.W., Goodman, A.G., Garrison, J.L., Taunton, J., Katze, M.G., Kaufman, R.J., and Hegde, R.S. (2007) The Role of p58IPK in Protecting the Stressed Endoplasmic Reticulum. Mol. Biol. Cell, 18:3681-91.
• Ong, H. L., Liu, X., Tsaneva-Atanasova, K., Singh, B. B., Bandyopadhyay, B. C., Swaim, W. D., Russell, J. T., Hegde, R. S., Sherman, A., and Ambudkar, I. S. (2007) Relocalization of STIM1 for activation of store-operated Ca2+ entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca2+ store. J. Biol. Chem., 282:12176-85.
• Stefanovic, S. and Hegde, R. S. (2007) Identification of a targeting factor for post-translational membrane protein insertion into the ER. Cell, 128:1147-1159.
• Alken, M. and Hegde, R. S. (2007) The translocation apparatus of the endoplasmic reticulum. In: Molecular machines involved in protein transport across cellular membranes, ed. R. Dalbey, C. Koehler, and F. Tamanoi. Academic press/Elsevier.
• Ong, H. L., Liu, X., Sharma, A., Hegde, R. S., and Ambudkar, I. (2007) Intracellular Ca2+ release via the ER translocon activates store-operated calcium entry. Pflugers Arch. 453:797-808.

2006

• ^*Kang, S. W., ^*Rane, N. S., Kim, S. J., Garrison, J. L., Taunton, J., and Hegde, R. S. (2006) Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell, 127:999-1013.
• Bernstein, H. D. and Hegde, R. S. (2006) The surprising complexity of signal sequences. Trends Biochem. Sci. 31:563-71.
• Ashok, A. and Hegde, R. S. (2006) Prions and retroviruses: an endosomal rendezvous? EMBO Rep. 7:685-687.
• Snapp, E. L. and Hegde, R. S. (2006) Rational design and evaluation of FRET experiments to measure protein proximities in cells. In Curr. Prot. in Cell Biol., ed. J. S. Bonifacino et al., Chapter 17:Unit 17.9, Wiley.
• Snapp, E. L., Sharma, A., Lippincott-Schwartz, J., and Hegde, R. S. (2006) Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells. Proc. Natl. Acad. Sci., 103(17):6536-6541.
• Chakrabarti, O. and Hegde, R. S. (2006) Trafficking of the cellular Prion protein and its role in neurodegeneration. In: Protein trafficking in the neuron, ed. A. Bean, Elsevier, 413-436.

2005

• ^*Shaffer, K. L., ^*Sharma, A., Snapp, E. L., and Hegde, R. S. (2005) Regulation of protein compartmentalization expands the diversity of protein function. Dev. Cell, 9:545-554.
• Brambillasca, S., Yabal, M., Soffientini, P., Stefanovic, S., Makarow, M., ^#Hegde, R. S., and ^#Borgese, N. (2005) Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition. EMBO J., 24:2533-2542.
• Garrison, J. L., Kunkel, E. J., ^#Hegde, R. S., and ^#Taunton, J. (2005) A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature, 436:285-289.
• ^*Menetret, J. F., ^*Hegde, R. S., Heinrich, S. U., Chandramouli, P., Ludtke, S. J., Rapoport, T. A., and Akey, C. W. (2005) Architecture of the ribosome-channel complex derived from native membranes. J. Mol. Biol., 348:445-457.
• Hegde, R. S. (2005) Protein translocation across the endoplasmic reticulum. In: Protein movement across membranes, pp. 1-18. ed. J. Eichler, Landes Bioscience, Georgetown, TX.
• Levine, C. G., Mitra, D., Sharma, A., Smith, C. L., and Hegde, R. S. (2005) The efficiency of protein compartmentalization into the secretory pathway. Mol. Biol. Cell, 16:279-291.
• Hegde, R. S. and Rane, N. S. (2005) The molecular basis of prion protein-mediated neuronal damage. In: Neurodegeneration and Prion Disease, pp. 407-450, ed. D. R. Brown, Springer, NY, NY.

2004

• Rane, N., Yonkovich, J., and Hegde, R. S. (2004) Protection from cytosolic prion protein toxicity by modulation of protein translocation. EMBO J., 23:4550-4559.
• ^*Karsten, V., ^*Hegde, R. S., Sinai, A. P., Yang, M., and Joiner, K. (2004) Transmembrane domain modulates sorting of membrane proteins in toxoplasma gondii. J. Biol. Chem. 279:26052-26057.
• Snapp, E. L., Reinhart, G. A., Bogert, B. A., Lippincott-Schwartz, J., and Hegde, R. S. (2004) The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells. J. Cell Biol. 164:997-1007.
• Tremblay P., Ball, H. L., Kaneko, K., Groth, D., Hegde, R. S., Cohen, F. E., DeArmond, S. J., Prusiner, S. B., and Safar, J. G. (2004) Mutant PrPSc conformers induced by a synthetic peptide and various prion strains. J. Virol., 78:2088-2099.

2003

• Snapp, E. L., Hegde, R. S., Francolini, M., Lombardo, F., Colombo, S., Pedrazzini, E., Borgese, N., and Lippincott-Schwartz, J. (2003) Formation of stacked ER cisternae by low affinity protein interactions. J. Cell Biol.,163:257-69.
• Hegde, R. S. and Rane, N. S. (2003) Prion protein trafficking and the development of neurodegeneration. Trends Neurol. Sci. 26:337-339.
• Fons, R. D., Bogert, B. A., and Hegde, R. S. (2003) Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane. J. Cell Biol. 160:529-539.

2002

• Hegde, R. S. (2002) Targeting and beyond: new roles for old signal sequences. Mol. Cell, 10:697-698.
• Kim, S. J. and Hegde, R. S. (2002) Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel. Mol. Biol. Cell, 13:3775-3786.
• Lingappa, V. R., Rutkowski, D. T., Hegde, R. S., and Andersen, O. S. (2002) Conformational control through translocational regulation: a new view of secretory and membrane protein folding. Bioessays, 24:741-748.
• Kim, S. J., Mitra, D., Salerno, J. S., and Hegde, R. S. (2002) Signal sequences control gating of the protein translocation channel in a substrate-specific manner. Dev. Cell,2:207-217.

2001

• Lingappa, V. R. and Hegde, R. S. (2001) Prion Protein Biogenesis: Implications for Neurodegeneration. In ‘Research and Perspectives in Alzheimer’s Diseases’. Beyreuther/Christen/Masters (Eds.) copyright Springer-Verlag Berlin Heidelberg.
• Kim, S. J., Rahbar, R., and Hegde, R. S. (2001) Combinatorial control of prion protein biogenesis by the signal sequence and transmembrane domain. J. Biol. Chem. 276:26132-26140 .
• Rutkowski, D. T., Lingappa, V. R. and Hegde, R. S. (2001) Substrate-specific regulation of the ribosome-translocon junction by N-terminal signal sequences. Proc. Natl. Acad. Sci. 98:7823-7828.

1990 to 2000 [publications as a student]

• Wilhelm, J. E., Vale, R. D., and Hegde, R. S. (2000) Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes. Proc. Natl. Acad. Sci., 97:13132-13137.
• Hegde, R. S., Tremblay, P., Groth, D., DeArmond, S. J., Prusiner, S. B. and Lingappa, V.R. (1999) Transmissible and genetic prion diseases share a common pathway of neurodegeneration. Nature, 402:822-826.
• Hegde, R. S. and Lingappa, V. R. (1999) Regulation of protein biogenesis at the endoplasmic reticulum membrane. Trends Cell Biol., 9:132-137.
• Hegde, R. S., Voigt, S., and Lingappa, V. R. (1998) Regulation of protein topology by trans-acting factors at the endoplasmic reticulum. Mol. Cell, 2:85-91.
• Hegde, R. S., Voigt, S., Rapoport, T. A., and Lingappa, V. R. (1998) TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum. Cell, 92:621-631.
• Hegde, R. S., Mastrianni, J. A., Scott, M. R., DeFea, K. A., Tremblay, P., Torchia, M., DeArmond, S. J., Prusiner, S. B., and Lingappa, V. R. (1998) A transmembrane form of the prion protein in neurodegenerative disease. Science, 279:827-834.
• Rusinol, A. E., Hegde, R. S., Chuck, S. L., Lingappa, V. R., and Vance, J. E. (1998) Translocational pausing of apolipoprotein can be regulated by membrane lipid composition. J. Lipid. Res., 39:1287-1294.
• Hegde, R. S. and Lingappa, V. R. (1997) Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum. Cell, 91: 575-582.
• Lingappa, J. R., Hill, R. L., Wong, M. L. and Hegde, R. S. (1997) A multi-step, ATP-dependent pathway for assembly of human Immunodeficiency (HIV) capsids in a cell-free system. J. Cell Biol., 136:567-581.
• Lingappa, V. R. and Hegde, R. (1997) Translocational pausing and the regulation of membrane protein biogenesis. in Membrane Proteins: structure, function and expression control. Edited by Naotaka Hamasaki and Katsuyoshi Mihara. Kyushu University Press (Japan), S. Karger AG (Switzerland).
• Kivlen, M. H., Dorsey, C. A., Lingappa, V. R. and Hegde, R. S. (1997) Asymmetric distribution of pause transfer sequences in apolipoprotein B-100. J. Lipid Res., 38: 1149-1162.
• Hegde, R. S. and Lingappa, V. R. (1996) Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol. Cell, 85:217-228.
• Hegde, R. S., Zuo, J., Voellmy, R. and Welch, W. J. (1995) Short circuiting stress protein expression via a tyrosine kinase inhibitor, Herbimycin A. J. Cellular Physiology, 165:186-200.
• Hegde, R. S. and Palfrey, H. C. (1991) Ionic effects on bumetanide binding to the activated Na/K/2Cl Cotransporter: Selectivity and Kinetic properties of ion binding sites. J. Membrane Biology, 126:27-37.
• Pewitt, E. B., Hegde, R. S., Haas, M., and Palfrey, H. C. (1990) The Regulation of Na/K/2Cl cotransport and bumetanide binding by protein phosphorylation and dephosphorylation. J. Biol. Chem., 265:20747-20756.
• Pewitt, E. B., Hegde, R. S., and Palfrey, H. C. (1990) 3H Bumetanide binding to avian erythrocyte membranes. J. Biol. Chem., 265:14364-14370.