Molecular basis for membrane remodelling and organization

Molecular basis for membrane remodelling and organization



Day 1 (Saturday for arrival)

17:00 – 17:30 Registration and cocktails
18:00 – 19:30 Dinner
19:45 – 20:00 Welcome
20:00 – 21:00 The EMBO Lecture (Plenary) James E Rothman (Fergus F. Wallace Professor of Biomedical Sciences Professor and Chair of Cell Biology, Professor of Chemistry, Executive Director of Center for High Throughput Cell, Yale University)
Title: Mechanism of membrane fusion


Topics and speakers for Days 2-5

The session times have yet to be assigned and so the list order given below will change. We expect that all participants will stay for the full length of the conference and either give a presentation (we have left lots of slots in the programme below to be filled from submitted abstracts) or at least a poster. We would like to engender as much exchange as possible between participants

Membrane curvature in vesicle fusion: How do two flat membranes fuse:

Speaker to be announced
Membrane fusion pore dynamics and SNARE protein zippering (François Darchen, Institut de Biologie Physico-Chimique, Université Paris)
Speaker selected from abstracts-
Speaker selected from abstracts-

Membrane curvature in endocytosis and vesicle budding I:

Vesicle formation in nerve terminals (Pietro De Camilli, HHMI, Yale University, USA)
The BAR domain proteins involved in caveola morphogenesis (Shiro Suetsugu University of Tokyo, Japan)
Speaker selected from abstracts- (Other endocytic mechanisms)
Speaker selected from abstracts-

Membrane curvature in endocytosis and vesicle budding II:

Mechanisms of membrane invagination and scission in clathrin-independent endocytosis (Ludger Johannes, Curie Institute, Paris)
COP coated vesicle budding and membrane deformation (Bruno Goud: Curie, France)
Speaker selected from abstracts-
Speaker selected from abstracts-

Actin and MEMBRANE DYNAMICS/endocytosis:

Actin dynamics and endocytosis in yeast
Assessing the molecular dynamics of clathrin-mediated endocytosis using quantitative live-cell imaging (David Perrais, Bordeaux University, France)
Assembly of Formin actin nucleation factors at the plasma membrane (Matthias Geyer, Dortmund, Germany)
Speaker selected from abstracts-

Shaping organelles and organisms:

Sensing membrane curvature (Bruno Antonny, CNRS Valbonne, France)
How the ER Gets Into Shape (Tom A. Rapoport, Harvard, Boston, USA)
Curvature and bacterial shape-
Speaker selected from abstracts-

Molecular modules that influence membrane curvature I (BAR domains, amphipathic helices etc):

I-BARs, actin and inverse membrane curvature (Pekka Lappalainen, University of Helsinki, Finland)
ESCRTs, BAR proteins and membrane curvature (Winfried Weissenhorn, Grenoble, France)
Speaker selected from abstracts-
Speaker selected from abstracts-

Molecular modules that influence membrane curvature II (dynamin):

Mammalian dynamin function (Joshua Zimmerberg, NIH Bethesda, USA)
Dynamin structure and function
Speaker selected from abstracts-
Speaker selected from abstracts-

Molecular modules that influence membrane curvature III (actin):

Signalling, actin and membrane dynamics (Pontus Aspenström, Karolinska Institute, Stockholm, Sweden)
Coupled dynamics of actin filaments and membranes in motile processes: a reconstitution approach (Marie-France Carlier Gif-sur-Yvette, Paris)
Speaker selected from abstracts-

Virus budding and fusion:

Enlarging the repertoire of class II viral membrane fusion proteins (Felix Rey, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France)
Speaker selected from abstracts-
Fusion in development and in viral entry (Leonid Chernomordik (NICHD, NIH, Bethesda, USA)
Speaker selected from abstracts-

Membrane dynamics and disease:

Hearing, Otoferlins and membrane fusion (Christine Petit, Institut Pasteur, Paris)
Salmonella infection, SifA and endosome tubulation (Stephane Meresse, Marseille, France)
Speaker selected from abstracts-
Speaker selected from abstracts-

Biophysics of curvature:

Molecular mechanisms of membrane curvature induction (Misha M Kozlov, Tel Aviv University, Israel)
Studying membrane curvature in cell trafficking with membrane nanotubes (Patricia Bassereau, Institute Curie, Paris)
Speaker selected from abstracts-

Methods applied to membrane curvature, insertion and diffusion:

Fluorescent methods for membrane curvature sensing (Dimitrios Stamou, University of Copenhagen, Denmark)
Biophysical methods for analysing protein-membrane interactions (Ralf Langan, Zilkha Neurogenetic Institute, Los Angeles, USA)
Force generation and Cell shape changes during tissue morphogenesis (Pierre-Francois Lenne Marseille, France)

Excursion or free time likely to be Monday afternoon
Banquet will be on the evening of day 4 (Tuesday)
Poster Sessions will be divided in two, being held in the evenings
Conference will finish with lunch on Thursday
Bus to Morlaix train station (25km away) / Brest airport (60km away)