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Nerve tracts within a brain organoid

Cerebral organoid at the air-liquid interface with long-range axon bundles color-coded by their directionality.

Research in the Lancaster lab is aimed at the study of human brain development. We do this by making use of an in vitro model system called cerebral organoids. These 3D self-organising neural tissues develop from human pluripotent stem cells and model many key aspects of early human brain development. Furthermore, they can accurately model a variety of neurodevelopmental disorders such as microcephaly. The goal of our research is to understand the mechanisms underlying human brain expansion. We are interested in this from an evolutionary perspective, but also in an effort to shed light on pathogenesis of neurodevelopmental disorders that affect brain size determination.

Brain organoid google group

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What are mini brains? - Madeline Lancaster
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Growing mini brains to discover what makes us human | Madeline Lancaster | TEDxCERN
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Human Brain Organoids Symposium - Madeline Lancaster
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Lancaster Lab News

New study on human brain evolution published in Cell

Lancaster Lab in the news

Scientists discover why the human brain is so big

The scientist who grows tiny brains in her laboratory

A mini revolution in brain science

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About us

We are a team of developmental neurobiologists, using a variety of interdisciplinary tools including stem cells, bioengineering, genetics, transcriptomics, bioinformatics, and gene editing (CRISPR/Cas9). Our mission is to develop and utilise novel technologies to study brain development and evolution in a dish.
Banner: artistic rendition of an organoid by Beata Edyta Mierzwa : BeataScienceArt.com

Contact Us

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom

Phone: +44 (0) 1223 267000

Website: http://www2.mrc-lmb.cam.ac.uk

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