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The human U1 snRNP recognises the 5' splice site. Solved by X-ray crystallography. PDB 3CW1, 4PJO, 4PKD — U1 snRNP

Two alternative splicing factors — A complex

The largest pre-assembled component of the spliceosome. Our first cryoEM structure. PDB 5GAN — Yeast U5.U4/U6 tri-snRNP

Originally visualised by the Luhrmann/Stark groups at 7 angstrom resolution, we recently obtained a structure of the human tri-snRNP at 2.9 angstrom resolution, our highest resolution cryo-EM structure. PDB ID 6QW6 — Human U5.U4/U6 tri-snRNP

The human pre-B complex, stalled prior to 5' splice site transfer. PDB ID 6QX9 — Human pre-B complex

Pre-catalytic spliceosome — B complex

The spliceosome captured immediately after branching. Solved by cryoEM. PDB 5LJ5 — C complex

The spliceosome immediately before exon ligation. Solved by cryoEM. PDB 5MQ0 — C* complex

The active site of the P complex, showing how the 3' splice site (black) is recognised by the branched lariat intron (grey). PDB 6EXN — P complex

Human P complex immediately after exon ligation. PDB ID 6QDV — Human P complex

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